Cytoskeleton of the Nervous System (Advances in Neurobiology, Vol. 3)

ABOUT THIS BOOK

1. Describes cytoskeleton in axonal development and pathology, microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein 2. Focuses on functional significance of neuronal cytoskeleton in axonal transport 3. Encourages further development of unifying principles, stimulates new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease

Without a cytoskeleton, a neuron or glial cell would be a shapeless jelly mass unable to function in the milieu of the brain. If we are to understand neuronal cells function in health and disease, we must determine how the cytoskeleton forms and contributes to neural physiology and pathobiology. Cytoskeleton of the Nervous System provides a comprehensive, authoritative and up-to-date account of what we now know and what we want to know in the near future--about the functioning of the cytoskeleton of neuronal cells at the molecular level. In lively accounts, which are unafraid to address controversy, Cytoskeleton of the Nervous System introduces readers to the most sophisticated concepts and latest discoveries: from overexpression systems to knock-out models for specific cytoskeletal proteins, from continuous transport assays in vivo to live-cell imaging in primary neurons, and from factors regulating cytoskeleton behavior to the dysregulation of these processes leading to neurological disease.

Content Level » Research
Related subjects » Neuroscience

AUTHORS & EDITORS

Ralph A. Nixon is the Director of Silberstein Institute and Center of Excellence on Brain Aging; a Professor of Psychiatry and Cell Biology at NYU Langone Medical Center; the Director of Research and The Center for Dementia Research at Nathan S. Kline Institute for Psychiatric Research. Aidong (David) Yuan is the Research Project Manager at the Center for Dementia Research, Nathan S. Kline Institute; a Research Assistant Professor of Psychiatry at New York University Langone Medical Center and New York University School of Medicine.