Nitric Oxide and Cancer. Prognosis, Prevention, and Therapy

About this book

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

Written for: Researchers, scientists, professionals, clinicians, physicians, and graduate students in the fields of cancer research, oncology, and pharmacology and toxicology.

Table of contents

1. Preface
2. Nitrous Oxide and Cancer
3. A role for eNOS in oncogenic Ras-driven cancer
4. Multifaced Role of NItric Oxide in Cancer Biology
5. Nitric oxide expression in cancer
6. S-Nitrosylation: How Cancer Cells Say NO to Cell Death
7. Cytotoxic and protective activity of nitric oxide cancers
8. Cytotoxic/protective activity of nitric oxide in cancer
9. Nitric oxide and life or death of human leukemia cells
10. Inhibition of apoptosis by endogenous nitric oxide in chronic lymphomatic leukemia
11. Nitric Oxide: a rate-limiting factor for metastases development
12. Nitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB-Snail-RKIP loop
13. Sensitizing effect of nitric oxide to cytotoxic stimuli
14. Nitric oxide is a promising enhancer for cancer therapy
15. Role of Nitric Oxide for Modulation of Cancer Therapy Resistance
16. Breaking Resistance: Role of Nitric Oxide in the Sensitization of Cancer Cells to Chemo-Immunotherapy
17. Prognostic significance of iNOS and NO in human melanoma
18. Prognostic significance of iNOS in heptatocellular carcinoma
19. Prognostic significance pf iNOS in esophageal cancer
20. Prognostic significance of nitrative DNA damage in infection and inflammatuion-related carcinogenesis
21. Nitric Oxide-releasing Melocules for Cancer Therapy and Chemoprevention
22. Nitric Oxide: monotherapy or sensitiser to conventional cancer treatments
23. Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies
24. S,R-3-Phenyl-4,5-dihydro-5-isoxazole Acetic Acide--Nitric Oxide GIT 27NO New Dress for Nitric Oxide Mission
25. Nitric Oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasis
26. Role of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of HIF-1a: Potential role of Se-Methylselenocysteine (MSC), an antioxidant multi-targeted small molecule