Narcolepsy. A Clinical Guide

About this book

This interdisciplinary volume brings together many of the world’s leading clinicians and researchers to discuss current and anticipated developments in the understanding of narcolepsy.

The volume is broadly divided into four main sections: Section I: Etiology; Section II: Clinical Considerations; Section III: Psychosocial considerations; and Section IV: Management. The areas covered include findings from research investigations on the genetic predisposition and pathophysiology, psychosocial aspects, and clinical management of narcolepsy by means of pharmacological and non-pharmacological methods. Special attention is paid to the translational aspects of narcolepsy.

This volume is suitable for sleep disorders specialists and researchers, psychiatrists, neurologists, psychologists, social workers, behavioral scientists, graduate medical students, and any professionals and researchers interested in the interdisciplinary area of sleep medicine.

Key Features

· Focus on issues faced in day-to-day clinical settings – helps to inform and change clinical practice
· Chapters address both clinical and research basis – highlights potential areas of future research
· Interdisciplinary and translational approach – suitable for a wide range of clinicians and biomedical professionals

Meeta Goswami, BDS, PhD, MPH, has been the director of the Narcolepsy Institute since its inception in 1985 and serves as an Assistant Professor of Neurology, Albert Einstein College of Medicine. Her general area of research interest includes narcolepsy and psychosocial issues.

S.R. Pandi-Perumal, M.Sc, is the President and Chief Executive Officer of Somnogen Inc, a New York Corporation. He is a well-recognized sleep researcher both nationally and internationally, and has authored many publications. His general area of research interest includes sleep and biological rhythms. He is a well-known editor in the field of sleep medicine and has edited over 15 volumes dealing with various sleep-related topics.

Michael J Thorpy, MD, has won many awards for his research including one of the sleep field's highest honors: the Nathaniel Kleitman Award. He is a well-published researcher and a board-certified sleep physician. He serves as a Professor of Neurology at Albert Einstein College of Medicine and the Director of the Sleep-Wake Disorders Center at Montefiore Medical Center, Bronx, New York.

Written for: Primary care physicians, sleep professionals, neurologists, psychiatrists, pediatricians, as well as psychologists, social scientists, and nurses - professionals who are interested in gaining a thorough knowledge on the neurobiological aspects of narcolepsy

Keywords:

cataplexy
daytime sleepiness
hypersomnias
hypnagogic
hypnopompic hallucinations
modafinil
narcolepsy
sleep medicine
sleep paralysis
sodium oxybate

Table of contents

Foreword
Clifford C. Saper, MD, PhD
Preface
Editors
Credits and Acknowledgements
Editors

SECTION I: ETIOLOGY

1. Narcolepsy: Genetic predisposition and pathophysiology
Emmanuel Mignot, MD, PhD.

2. Animal models of narcolepsy: Developments, findings, and perspectives
Christopher M. Sinton, PhD.

3. Neuroimaging of narcolepsy
Eric A. Nofzinger, MD.

SECTION II: CLINICAL CONSIDERATIONS

4. Epidemiology of narcolepsy
Lauren Hale, PhD.

5. Narcolepsy in Childhood
Shalini Paruthi, MD. & Suresh Kotagal, MD.

6. Narcolepsy in the Older Adult
Hrayr Attarian, MD.

7. Diurnal and nocturnal sleep in narcolepsy with cataplexy
Yves Dauvilliers, MD, PhD & Giuseppe Plazzi, MD, PhD

8. Hypnagogic Hallucinations and Sleep Paralysis
Armando D’Agostino, MD & Ivan Limosani, MD.

9. REM sleep behaviour disorder in narcolepsy with cataplexy.
Giuseppe Plazzi, MD, PhD & Yves Dauvilliers, MD, PhD.

10. Narcolepsy and other comorbid medical illnesses
Lori A. Panossian, MD & Alon Y. Avidan, MD, MPH.

11. Humor processing in human narcolepsy with cataplexy
Aurélie Ponz & Sophie Schwartz, PhD.

12. Dreams in patients with narcolepsy
Michael Schredl

13. Psychoanalysis and narcolepsy
James F Pagel, MS, MD & Lawrence Scrima, PhD

14. Symptomatic narcolepsy or hypersomnia, with and without hypocretin (orexin) deficiency
Kanbayashi T, Nakamura M, Shimizu T, & Seiji Nishino, MD, PhD.

15. Hypersomnias other than narcolepsy: Differential diagnosis
Michel Billiard, MD.

SECTION III: PSYCHOSOCIAL CONSIDERATIONS

16. Psychosocial impact of narcolepsy in children and adolescents
Gregory Stores MA, MD, DPM, FRCPsych, FRCP.

17. Quality of life and psychosocial issues in narcolepsy
Meeta Goswami BDS, MPH, PhD.

18. Narcolepsy, Intimacy and Sexuality
Gila Lindsley, Ph.D.

19. Narcolepsy, driving and traffic safety
Claire EHM Donjacour, Monique AJ Mets, Joris C Verster, PhD.

20. Memory and Cognition in Narcolepsy
Christian Bellebaum, & Irene Daum, PhD.

21. Medico-legal aspects of disability in narcolepsy
Francesca Ingravallo and Giuseppe Plazzi

22. Narcolepsy and mental health
John Shneerson, MA, DM, MD, FRCP, FCCP

SECTION IV: MANAGEMENT

23. Overview of management of narcolepsy
Seiji Nishino, MD, PhD.

24. Modes of action of drugs related to narcolepsy: Pharmacology of wake-promoting compounds and anticataplectics
Seiji Nishino, MD, PhD & Nozomu Kotorii, MD, PhD.

25. Modafinil/ Armodafinil in the Treatment of Narcolepsy
Michael Thorpy, MD

26. Sodium oxybate in the treatment of narcolepsy
Geert Mayer

27. Emerging treatments for narcolepsy
Meredith Broderick MD & Christian Guilleminault MD, BiolD.

28. Non-pharmacologic Treatments of Narcolepsy
Renee Monderer, MD, Shelby Freedman Harris, PsyD, CBSM. & Michael J. Thorpy, MD.