Tocotrienols. Vitamin E beyond Tocopherols

Description

The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters.

Highlights

• Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer
• Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health
• Tocopherol interference with tocotrienol functions
• All new chapters and many new contributors

Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.

Features

• Focuses on established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer
• Looks forward with emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health
• Updated with many new chapters and contributors

Table of Contents

• Tocotrienols in Plants: Occurrence, Biosynthesis, and Function
  Maren Müller, Jana Cela, María A. Asensi-Fabado, and Sergi Munné-Bosch
• Safety of Unsaturated Vitamin E Tocotrienols and Their Isomers
  Alexander G. Schauss, John R. Endres, and Amy Clewell
• Bioavailability and Metabolism of Tocotrienols
  Zhihong Yang, Mao-Jung Lee, Shengming Sang, and Chung S. Yang
• Bioavailability of Tocotrienols and Interference of Their Bioavailability by α-Tocopherol Supplementation
  Saiko Ikeda, Tomono Uchida, and Chisato Abe
• Alpha-Tocopherol: A Detriment to Tocotrienol Benefits
  Anne M. Trias and Barrie Tan
• Antiangiogenic Effects of Tocotrienol
  Takahiro Eitsuka, Kiyotaka Nakagawa, and Teruo Miyazawa
• Mechanism of Delta-Tocotrienol on Colorectal Cancer
  Sayori Wada and Yuji Naito
• Targeted Prostate Cancer Chemoprevention Trial with Tocotrienols
  William L. Stone, Victoria P. Ramsauer, Sharon E. Campbell, and Koymangalath Krishnan
• δ-Tocotrienol: Demethylated Vitamin E with Hormetic Function and Therapeutic Application in Breast Cancer
  Francesca Pilolli, Marta Piroddi, Elisa Pierpaoli, Silvia Ciffolilli, Mauro Provinciali, and Francesco Galli
• Mevalonate-Suppressive Tocotrienols for Cancer Chemoprevention and Adjuvant Therapy
  Huanbiao Mo, Manal Elfakhani, Anureet Shah, and Hoda Yeganehjoo
• Potential of Tocotrienols in Lung Cancer
  Xiangming Ji, Arvind Goja, and Smiti V. Gupta
• Tocotrienols and Atherosclerosis: Potential in Cardioprotection
  Hapizah Mohd Nawawi
• Tocotrienols: Viable Options for Managing Metabolic Diseases
  Chi-Wai Wong
• Tocotrienols as Possible Treatments for Obesity
  Wong Weng-Yew and Lindsay Brown
• Tocotrienols, Inflammation, and Cancer: How Are They Linked?
  Sahdeo Prasad, Bokyung Sung, Sridevi Patchva, Subash C. Gupta, and Bharat B. Aggarwal
• 1-Modulating NF-κB Activity by Tocotrienols
  Mary Kaileh and Ranjan Sen
• Antioxidant Action of Tocotrienols
  Etsuo Niki
• Tocotrienol in Human Pancreatic Cancer
  Mokenge P. Malafa and Kazim Husain
• Tocotrienols in the Treatment of Dyslipidemia
  Mark Houston
• Tocotrienols and Vascular Effects
  Aida Hanum Ghulam Rasool
• Prolongevity Effects of Tocotrienols: Trials in Caenorhabditis elegans
  Noriko Kashima, Yukiko Fujikura, Tomomi Komura, Yoshikazu Nishikawa, Keiji Terao, and Barrie Tan
• Anti-Tyrosinase Activity of Tocotrienol in Skin Blemishes
  Daniel Yee Leng Yap
• Tocotrienols and Bone Health
  Ima Nirwana Soelaiman, Norazlina Mohamed, Ahmad Nazrun Shuid, and Norliza Muhammad
• Tocotrienol and Physiology of Reproduction
  M.H. Rajikin, N. Mokhtar, A. Chatterjee, and Y.S. Kamsani
• Tocotrienol and Tocopherol in Stress-Induced Gastric Mucosal Injury
  Nafeeza Mohd Ismail and Ibrahim Abdel Aziz Ibrahim
• Structural Modification of Tocotrienols to Improve Bioavailability
  Awantika Singh, Philip J. Breen, Sanchita Ghosh, K. Sree Kumar, Kottayil I. Varughese, Peter A. Crooks, Martin Hauer-Jensen, and Cesar M. Compadre
• Index

Author Bio(s)

Barrie Tan is the President of American River Nutrition, Inc. in Hadley, Massachusetts, USA.

Ronald Ross Watson is a Professor in the College of Public Health and School of Medicine at the University of Arizona, Tucson, USA.

Victor R. Preedy is the Director of the Genomics Centre at King's College London, UK.