Thyroid Cancer: From Emergent Biotechnologies to Clinical Practice Guidelines

Description

The current age of clinical medicine is witnessing biotechnological innovation at an unprecedented pace. As a result, the recently popularized clinical practice guidelines (CPG), as a tool to assist clinical decision-making, have been struggling to keep up. Thyroid Cancer: From Emergent Biotechnology to Clinical Practice Guidelines rides the wave of medical innovation, analyzing current and future CPG, and providing an up-to-date and comprehensive treatise on thyroid cancer, its diagnosis, and treatment.

A synthesis of ideas by prominent world experts in the field of thyroid cancer research and clinical practice, Thyroid Cancer covers:

• Technologically-advanced diagnostic procedures and therapeutic interventions
• Diagnostic techniques employed in the detection and follow-up of thyroid cancer including ultrasound, needle aspiration techniques, CT, PET, PET-CT, and MRI
• Basic principles of systems biology, molecular and translational medicine, CPG development, and risk stratification for thyroid cancer
• How CPG contain knowledge gaps and produce uncertainty
• Advances in the field, including new surgical techniques, molecular targeted therapies, external beam radiation therapy, and chemotherapy

A comprehensive, scientific description of current and future diagnostic and therapeutic modalities for the management of thyroid cancer, this treatise is an indispensible reference for both the specialist and referring physician.

Features

• Vision of biotechnologies that are realistically going to impact the care of thyroid cancer patients
• Description of molecular medicine in thyroid cancer by the actual researchers conducting the pivotal studies in the field
• Comprehensive organization of material covering all aspects of thyroid cancer management for the present time and near future
• Extensive inclusion of figures and images describing cutting edge technologies
• Synthesis of emergent biotechnologies into a practical approach that may be reflected in forthcoming clinical practice guidelines

Table of Contents

• Principles of Translational Medicine and Applications to Thyroid Cancer Investigation
  Emily Jane Gallagher and Derek LeRoith
• Systems Biology—An Overview
  Ravi Iyengar and Azi Lipshtat
• Genetic and Epigenetic Alterations in the MAP Kinase and PI3K/Akt Pathways in Thyroid Cancer
  Mingzhao Xing and Paul W. Ladenson
• Genetic and Molecular Pathophysiology of Medullary Thyroid Carcinoma
  Rosa Maria Paragliola, Salvatore M. Corsello, Francesco Torino, and Agnese Barnabei
• Risk Stratification in Differentiated Thyroid Cancer
  Giuseppe Barbesino
• Clinical Practice Guidelines for Thyroid Cancer: Where Are We Now?
  Jeffrey I. Mechanick
• Illustrative Case Studies of Thyroid Carcinoma and the Emerging Role of Molecular Medicine
  Donald Bergman and Rhoda H. Cobin
• Advances in Thyroid Ultrasound for Detection and Follow-Up of Thyroid Malignancies: Technical and Clinical Aspects
  Laurence Leenhardt, François Tranquart, and Jean Tramalloni
• Multimodality Imaging and Aspiration Biopsy Guidance in the Perioperative Management of Thyroid Carcinoma
  Jing Gao, Jonathan K. Kazam, and Elias Kazam
• The Use of Diagnostic Radiotracers in Thyroid Cancer
  Josef Machac
• PET-CT Scanning in the Management of Thyroid Cancer: Experience with a Cohort of 100 Patients
  Dario Casara, Faise Al Bunni, Maria Rosa Pelizzo, and Fabio Pomerri
• The Emerging Role of Percutaneous Needle Biopsy and Molecular Tumor Marker Analysis for the Preoperative Selection of Thyroid Nodules
  Angelo Carpi, Jeffrey I. Mechanick, and Andrea Nicolini
• Image-Guided Mini-Invasive Ablation of Thyroid Tumors and Distant Metastases
  Enrico Papini, Antonio Bianchini, Rinaldo Guglielmi, Claudio M. Pacella,Irene Misischi, Laura Papini, and Giancarlo Bizzarri
• Thyroidectomy and Neck Exploration: New Surgical Approaches
  Jean-Christophe Lifante and William B. Inabnet III
• Thyroid Surgery Performed under Local Anesthesia and Same-Day Surgery
  Joseph DiNorcia and John D. Allendorf
• The Use of Therapeutic Radiotracers in Thyroid Cancer
  Josef Machac
• External Beam Radiation Therapy in Thyroid Cancer
  Walter Choi and Louis Harrison
• Role of Chemotherapy in Thyroid Cancer
  Paolo Bossi and Laura D. Locati
• Role of NF-κB in Thyroid Cancer
  Eriko Suzuki, Shunichi Yamashita, and Kazuo Umezawa
• Biologically Targeted Therapies for Thyroid Cancers
  Steven I. Sherman
• Molecular Targeted Therapies of Medullary Thyroid Carcinoma
  Francesco Torino, Agnese Barnabei, Rosa Maria Paragliola, and Salvatore M. Corsello
• Synthesis of Emergent Biotechnologies into Future CPG
  Jeffrey I. Mechanick, Angelo Carpi, Mark Urken, Donald Bergman, and Rhoda H. Cobin

Authors

Angelo Carpi, MD is a clinical researcher at the University Hospital of Pisa. He is also an associate professor of Internal Medicine at Pisa University.
Jeffrey I. Mechanick, MD, Mount Sinai School of Medicine, New York City, is a Clinical Professor within the Department of Medicine, Division of Endocrinology, Diabetes, and Bone Disease at the Mount Sinai School of Medicine.