Nutritional Genomics. the Impact of Dietary Regulation of Gene Function on Human Disease

Description

Written as a platform for researchers, scientists, educators, and policy makers to discuss the current status of nutritional genomic research, this book contains the latest scientific findings on the mechanisms underlying diet-genome interactions. With contributions from renowned experts, it covers information on transforming dietary signals into disease-preventing changes in gene expression, gene-linked networks of chronic disease and cancer, and the role of food science and nutrition to meet individual genomic health needs. The book identifies future directions for research and challenges and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.

Features

• Includes contributions from recognized researchers in the field of Nutritional Genomics
• Places a new perspective on understanding the gene networks that define the metabolic pathways involved in chronic diseases
• Describes varied mechanisms of gene expression related to chronic disease, such as obesity and T2DM, inflammation, and cancer
• Identifies the key role of the agriculture-food industries to deliver whole foods containing the requisite bioactive components
• Includes an assessment of the future of Personalized Nutrition

Table of Contents

• Transforming Dietary Signals into Disease-Preventing Changes in Gene Expression
• Using the "Omics" of Nutrition to Identify Molecular Targets; Koss
• Nutritional Epigenomics of Metabolic Syndrome; TBA
• Epigenetic Control of Chemopreventive and Cardioprotective Gene Expression; Rodriguez
• Informatics Approaches to Nutritional Genomics; Zhu
• Co-3 Fatty Acids: Nutritional Modulation of Atherosclerosis; Kelley
• Bioinfomatics: Analysis of Gene Networks to Identify Regulatory Sites; Dawson
• Nuclear Receptors Coactivators: Physiology, Metabolism and Disease; Lonard

Theme II: Gene Linked Networks of Chronic Disease and Cancer

• Adipose Tissue Gene Expression: Inflammation and Obesity (PPARs); Muller
• T2DM: Gene Networks and Transcription; Attie
• Insulin Resistance and T2DM: Adipose Tissue Macrophage and Inflammation; Olefsky
• Network Analysis of Gene Expression in Breast Cancer Cells; Dewey
• Bioactive Food Components and the "U" Shaped Health Conundrum: Vitamin D and Folate as Examples of Friends and Foes; Milner
• Skin Cancer Chemoprevention by Green Tea Polyphenols; Katiyar
• Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention; Dong
• Human Intestinal Microbiome: Etiology of Inflammation Genomics; Clemens
• Nutritional Genomics: Personalized Nutrition Targeted to Specific Gene Responses; Draper

Theme III: Role of Food Science and Nutrition to Meet Individual Genomic Health Needs

• Nutrient Biofortification of Crops; Hirschi
• Using Genomics-aided breeding to Improve Nutritional Content of Lettuce; Still
• Functional Foods Containing Model Bioactive Agents; Craig
• Resveratrol Alters Global patterns of gene Regulation and Improves Physiology; Baur
• Cocoa Supplementation: Formulation Challenges and measurement of Bioactives; Wagner
• Manufacture of Functional Foods: Bioavailability; Floros
• New Whole Foods Designed to Deliver Bioactive Components; Mitchell
• Food Labels and Ads for Nutritional Genomics; Cadman
• Discussion of Future Potential for Nutritional Genomic Products; Leveille, Bidlack, Rodriguez, Draper

Author

Dr. Bidlack received his Bachelor of Science degree in Dairy Science and Technology from the Pennsylvania State University (1966), his Master of Science degree in Food Science from Iowa State University (1968), and his Ph.D. Degree in Biochemistry from the University of California, Davis (1972). In addition, he was a postdoctoral fellow in Pharmacology at USC School of Medicine (1972-1974).