A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

DESCRIPTION

An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, students, scientists, and doctors working, learning, and teaching in the field of TB. It contains 100 color photographs and illustrations that bring clarity to the information presented.

The atlas takes the unusual approach of covering multiple species histopathology, arguably the first and quite possibly the only resource to do so. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists to distinguish between the features of all major animal models available and to use them with their strengths and limitations in mind. The book provides guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates.

Features

• Provides a starting point for non-histopathologists to understand the histopathology of TB and how it relates to their research work
• Reviews the basic features necessary to understand the functional and pathological changes that can occur in this organ
• Summarizes new microbiological and histological observations in the Wistar rat TB model
• Focuses on general aspects of drug discovery in addition to specific points relating to TB
• Includes 100 color photographs and illustrations

TABLE OF CONTENTS

Drug Discovery for Neglected Diseases of the Developing World, P. Herrling
Background
The Drug Discovery Process
Therapeutic Tools
Drug Discovery Phases
Phase I–Phase IIa
Phase IIb–Phase III
References

Tuberculosis Biology and Drug Discovery, T. Dick
Disease Manifestations and Treatment
A Largely Unment Medical Need
The Challenge of TB Drug Discovery
An At las for TB Drug Discovery
References

Immunopathology of Tuberculosis Disease across Species, V. Dartois
Overview of Species Specific Characteristics
A Macroscopic View of TB-Infected Lungs across Species
Summary and Lessons Learned
References

Anatomy and Histology of the Human Lung, F.J.W.-M. Leong and A. S.-Y. Leong
Gross Structure
Microscopic Structure
References

Pathology of Tuberculosis in the Human Lung, F.J.W.-M. Leong, S. Eum, L.E. Via, and C.E. Barry, 3rd
Introduction
Features
Variations
References

Pulmonary Tuberculosis in Monkeys, J.L. Flynn and E. Klein
Introduction
Inoculum and Route of Infection
Features
Variations
Strengths of This Animal Model
Shortcomings
References

Pulmonary Tuberculosis in the Rabbit, G. Kaplan and L. Tsenova
Introduction
Inoculum and Route of Inoculation
Features
Strengths of This Animal Model
Shortcomings
References

Pulmonary Tuberculosis in the Guinea Pig, R.J. Basaraba and I.M. Orme
Introduction
Inoculum and Route of Inoculation
Features
Strengths of This Animal Model
Shortcomings
References

Pulmonary Tuberculosis in the Rat, A. Singhal, E.M. Aliouat, C. Creusy, G. Kaplan, and P. Bifani
Introduction
Inoculum and Route of Inoculation
Features
Variations
Strengths of This Animal Model
Shortcomings
References

Pulmonary Tuberculosis in the Mouse, S. Bharath and V. Balasubramanian
Introduction
Inoculum and Route of Inoculation
Features
Variations
Strengths of This Animal Model
Shortcoming
References

Glossary
Index

Editor(s): Franz Joel Leong, Novartis Institute for Tropical Diseases, Singapore; Veronique Dartois, Novartis Institute for Tropical Diseases, Singapore; Thomas Dick, Novartis Institute for Tropical Diseases, Singapore