Arthritis: Pathophysiology, Prevention, and Therapeutics

Description

A debilitating disease of pain, inflammation, and loss of mobility and quality of life, arthritis takes victims of all ages, from young children to seniors. Usually chronic, the broad term arthritis refers to nearly 100 distinct manifestations, each with their own etiology, pathophysiology, and treatment. With medical research getting so much attention, it is no wonder there have been recent leaps in the investigation into arthritis treatment. It is important to have a high quality, trusted compendium to capture the breadth and depth of new information in the field.

Covering cutting-edge information on arthritic diseases and their treatment, Arthritis: Pathophysiology, Prevention, and Therapeutics details the intricacies of arthritis and inflammatory responses, their consequences, their economic burden, and their impact on society. Offering a mechanistic approach to pathophysiology and treatment, the book begins with an overview of rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

Section Two highlights the consequences of arthritis and the link between arthritis and obesity, diabetes, and cardiovascular disease, as well as other related disabilities. The third section focuses on antiarthritic drugs, including an overview and update on antiarthritic drug development by Dr. Micheal G. Lyon from Stanford University School of Medicine, and a chapter on nonsteroidal anti-inflammatory drugs. Other chapters cover biologics in arthritis treatment, topical applications, and the use of hyaluronan and hyaluronic acid in osteoarthritis and rheumatoid arthritis.

Sections Four and Five are devoted to natural therapeutic and orthopedic interventions such as glucosamine and chondroitin, MSM, capsaicin, shark cartilage, and fish oil, while Section Six discusses nonpharmacological approaches including physical exercise and acupuncture. The final section provides a commentary on the correlation between arthritis and the aging society and how exercise, nutrition, and preventative strategies can help the world and mankind in promoting human health.

Features

• Supplies extensive references
• Provides a general historical introduction to arthritis care
• Addresses non-pharmacologic interventions including exercise and acupuncture
• Discusses safety and toxicity of synthetic drugs, including Celebrex and Vioxx
• Offers tables, figures, and charts to aid with comprehension

Table of Contents

• Overview and Pathophysiology
• An Overview on Rheumatologic Disorders, S. Kumar and R. Gupta
• Pathogenesis of Osteoarthritis, A.P. Anandarajah
• Biomarkers in Osteoarthritis, M. Ishijima, H. Kurosawa, H. Kaneko, and K. Kaneko
• Rheumatoid Arthritis: Disease Pathophysiology, A. Saxena, S.K. Raychaudhuri, and S.P. Raychaudhuri
• Osteoclasts and Interleukin-17-Producing Helper T Cells in Rheumatoid Arthritis, K. Okamoto and H. Takayanagi
• WNT/β-Catenin Signaling Modulating Osteoarthritis, M. Corr
• Psoriatic Arthritis: Epidemiology, Risk Factors, and Quality of Life, A.R. Setty
• Consequences
• Arthritis, Obesity, Increased Cardiovascular Risk, and Disability, S. Chatterjee
• Antiarthritic Drugs
• An Overview: Use of Traditional Antiarthritic Drugs and Update on Drug Development, G. Schmajuk and M.G. Lyon
• Nonsteroidal Anti-Infl ammatory Drugs, A. Lal and S. Sharma
• Biologics: Target-Specifi c Treatment of Systemic and Cutaneous Autoimmune Diseases, S.P. Raychaudhuri and S.K. Raychaudhuri
• Topical Applications for Pain and Arthritic Diseases, N. Tanida, K. Maekawa, and M. Nakanishi
• Hyaluronic Acid and Arthritis: A Review, M. Abate
• Hyaluronan for the Treatment of Osteoarthritis and Rheumatoid Arthritis, T. Nakano and Y. Takahashi
• Natural Therapeutic Interventions
• Immunomodulatory Activities of Japanese Traditional Medicines in Rheumatoid Arthritis, T. Kogure
• An Overview on Natural Therapeutic Interventions, S. Naguwa
• Potential Health Benefi ts from Nutrition and Dietary Supplements in the Prevention of Osteoarthritis and Rheumatoid Arthritis, C.C. Rosenbaum
• Antiarthritic Potential of Glucosamine and Chondroitin: An Overview, M.W. Orth and P.S. Chan
• An Overview on N-Acetylglucosamine and Arthritis, D. Kubomura, U. Naoaki, and Y. Matahira
• Hexosamine Flux and the Efficacy and Safety of Glucosamine in the Treatment of Osteoarthritis, A. Afshan A.W. Salminen, and J.E. Leakey
• Safety and Efficacy of a Unique Undenatured Type II Collagen in the Treatment of Arthritis, S.P. Raychaudhuri, R.C. Gupta, H. Moriyama, M. Bagchi, F.C. Lau, and D. Bagchi
• Targeting Inflammatory Pathways by Nutraceuticals for Prevention and Treatment of Arthritis, B. Sung, G. Sethi, K.S. Ahn, M.K. Pandey, A.B. Kunnumakkara, and B.B. Aggarwal
• Boswellia serrata for Arthritis Relief: A Journey from Frankincense to Aflapin and 5-Loxin, A.V. Krishnaraju, K. Sengupta, S.P. Raychaudhuri, and G. Trimurtulu
• Utilization of Marine Products in the Treatment and Prevention of Osteoarthritis, T. Tamai, A. Honmura, H. Yoshioka, T. Konishi, S. Kuninaga, H. Oda, A. Sakamoto, and T. Okada
• Benefits of Fish Oil for Rheumatoid Arthritis: A Review, C. Dawczynski and G. Jahreis
• Potential Health Benefits of n-3 and -6 Fatty Acids in Selected Plant Seed Oils in Rheumatoid Arthritis, H. Takeuchi, H. Moriyama, D. Bagchi, and S.P. Raychaudhuri
• Antiarthritic Potential of Bromelain from Ananas comosus and Its Combination, D. Ghosh
• Anti-Inflammatory Properties of Zingiber officinale var. Rubra (Red Ginger Extract), H. Shimoda
• Benefits of Radix Tripterygium wilfordii for Rheumatoid Arthritis, X. He, S. Xu, M. Jiang, N. Lin, and A. Lu
• Dehydroepiandrosterone (DHEA): A Review of Its Preclinical Use in the Management of Osteoarthritis, K. Huang, H.l. Cai, C. Zhang, X.-w. Zhang, L.d. Wu, L.f. Shen, and Q.f. Guo
• Antiarthritic Potential of Green-Lipped Mussel and Other Marine-Based Nutraceuticals, W. Pearson and M.I. Lindinger
• Antioxidant, Anti-Inflammatory, and Anticatabolic Potential of Rosmarinic Acid and High-Rosmarinic Acid Mint (Mentha Spicata) in Osteoarthritis, W. Pearson and M.I. Lindinger
• Potential Health Benefits of Orally Administered Hyaluronan in Alleviating Knee Joint Pain, T. Kanemitsu and A. Asari
• PycnogenolA Nutraceutical for Osteoarthritis, O.P. Gulati
• Orthopedic Approach
• Total Knee Arthroplasty for Osteoarthritis, S. Matsuda, H. Miura, and Y. Iwamoto
• Nonpharmacologic Interventions
• Physical Exercise for Osteoarthritis of the Knee: Main Modality of Treatment and Possible Use for Prevention, H. Kurosawa
• Acupuncture for the Treatment of Arthritis, H.J. Park and H. Lee
• Rehabilitative Strategies for Arthritis: Physical, Agents, Exercise, and Prosthesis Therapies, N. Kawate, M. Yoda, N. Yoshioka, and M. Mizuma
• Rehabilitation for Arthritis: Daily Life Guidelines, F. Kasai and M. Mizuma
• Commentary
• Arthritis, Aging Society, Exercise, Nutrition, and Other Precautionary Measures, S.P. Raychaudhuri, H. Moriyama, and D. Bagchi
• Index

Authors

Debasis Baghchi, Ph.D., FACN, CNS, MAIChE, works within the Department of Pharmacy Sciences at University of Houston College of Pharmacy.
Hiroyoshi Moriyama is Founder and Owner of MTI, Inc., a research and development company aimed at producing nutraceutical and cosmeceutical ingredients.