Parkinson's Disease

Description

In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the incidence and importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances have been implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, as well as aspects of the pathophysiology, pathogenesis, and treatment of PD.

Features

• Includes new chapters on non-motor features of Parkinson’s disease (PD), pathophysiology, pathogenesis, and treatment
• Uses visual models to simplify difficult-to-understand concepts
• Emphasizes therapeutics including new drugs, future therapies, and clinical trials
• Discusses cutting-edge research including gene and stem cell therapy
• Covers the clinical aspects of the treatment of both motor and non-motor aspects of PD in depth
• Investigates the genetic aspects of PD, and possible pathophysiologic mechanisms responsible for PD
• Describes non-pharmacologic treatment measures and quality-of-life issues in PD

Reviews

“… brought together experts from across the vast field of PD research to create an invaluable reference, outlining our current understanding of this disease. With 78 chapters across 8 primary themes, this massive text contains all the information that any student new to the field requires to develop a thorough understanding of PD. With chapters about everything form epidemiology, to theories of pathogenesis, and back to symptoms and treatment, this book covers the entire range of what we can know about a biological phenomenon, from the molecular, cellular and genetic levels, through to the whole human being and the entire human population. … Overall, this book is truly a success. Extremely broad in its coverage of the topic, and generally very well written, and in a way that is accessible to both seasoned veterans of Parkinson’s research, looking for the last information in an area outside their direct expertise, and novices, trying to grasp an understanding of the extent of our current knowledge of PD.”
—Elissa M. Strome, Department of Experimental Medical Science, Lund University, Sweden, in the Journal of Chemical Neuroanatomy, Vol. 33, No. 4, February 2007

”I would recommend it highly to those with a specialist’s interest in Parkinson’s disease and to more general neurologists who want an accessible, readable guide to diagnosing and treating this disease.”
—New England Journal of Medicine, September 2005

”…tightly constructed and well organized. It stands out as the most comprehensive volume available on this disorder.”
—JAMA, Volume 293, 2005

“A new encyclopedic collection of clinical wisdom…the largest and most comprehensive of several reference books that focus on this illness….masterfully organized.”
—Parkinson’s Disease Update, Issue 145, 2005

Table of Contents

• Overview
• James Parkinson
  Jennifer G. Goldman and Christopher G. Goetz
• Parkinson’s Disease: Where Have We Been?
  Lawrence W. Elmer
• Parkinson’s Disease: Where Are We?
  Raúl de la Fuente-Fernández

• Epidemiology
• Epidemiology of Parkinson’s Disease: An Overview
  Monica Korell and Caroline M. Tanner
• Environmental Toxins and Parkinson’s Disease
  Jason R. Cannon and Timothy J. Greenamyre
• Rural Environment and Parkinson’s Disease
  Daniel Strickland
• Industrial and Occupational Exposures and Parkinson Disease
  Samuel Goldman
• Tetrahydroisoquinolines and Parkinson’s Disease
  Mark S. LeDoux
• Endogenous Neurotoxins in the Pathogenesis and Progression of Parkinson’s Disease
  Shaik Shavali and Manuchair Ebadi

• Genetics
• Overview of the Genetics of Parkinsonism
  Mathias Toft and Zbigniew K. Wszolek
• α-Synuclein and Parkinson’s Disease
  Thomas Gasser
• LRRK2-Associated Parkinson’s Disease
  Jonathan Carr and Soraya Bardien
• Parkin-Associated Parkinson’s Disease
  Anne Grünewald and Christine Klein
• PINK1- and DJ-1-Linked Parkinsonism
  Eng-King Tan
• Genetic and Bioinformatic Tools in Parkinson’s Disease
  Tatiana Foroud and Nathan Pankratz

• Clinical Features of Parkinson’s Disease
• Tremor, Rigidity, and Bradykinesia
  Kelvin L. Chou and Howard I. Hurtig
• Gait Disorders in Parkinson’s Disease
  Yacov Balash, Jeffrey M. Hausdorff, Tanya Gurevich, and Nir Giladi
• Somesthesia
  Padraig O’Suilleabhain
• Pain in Parkinson’s Disease
  Blair Ford
• Restless Legs Syndrome and Periodic Limb Movements of Sleep
  Bryan T. Klassen and Charles H. Adler
• Fatigue: A Common Comorbidity in Parkinson’s Disease
  Anelyssa D’Abreu and Joseph H. Friedman
• Visual Dysfunction in Parkinson’s Disease
  Robert L. Rodnitzky
• Visuo-Cognitive Dysfunctions in Parkinson’s Disease
  Andrea Antal, Walter Paulus, and Ivan Bodis-Wollner
• Olfactory Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes
  Katerina Markopoulou and Bruce A. Chase
• Insomnia and Excessive Daytime Sleepiness in Parkinson’s Disease
  J.A. Van Gerpen and Pablo Castillo
• REM Sleep Behavior Disorder
  Aleksandar Videnovic and Cynthia L. Comella
• Gastrointestinal Dysfunction in Parkinson’s Disease
  Ronald F. Pfeiffer
• Urological Dysfunction
  Carlos Singer and Henry Moore
• Sexual Dysfunction
  Cheryl Waters and Janice Smolowitz
• Cardiovascular Autonomic Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes
  Valeria Iodice, David Low, Ekawat Vichayanrat, and Christopher J. Mathias
• Disorders of Thermoregulation in Parkinson’s Disease
  Thomas L. Davis
• Respiratory Dysfunction
  Holly Shill
• Depression in Parkinson’s Disease
  Steven P. Wengel, Dennis P. McNeilly, and William J. Burke
• Anxiety and Parkinson Disease
  Jeremy Quickfall, Michael Trew, and Oksana Suchowersky
• Apathy in Parkinson’s Disease
  Howard D. Weiss and Laura Marsh
• Dementia
  Anne L. Barba, B. Kelly Changizi, Donald S. Higgins, Stewart A. Factor, and Eric S. Molho

• Pathophysiology of Parkinson’s Disease
• Animal Models of Basal Ganglia Injury and Degeneration and Their Application to Parkinson’s Disease Research
  Giselle M. Petzinger and Michael W. Jakowec
• Neuroanatomy of Parkinson’s Disease
  Heiko Braak and Kelly Del Tredici-Braak
• Neuropathology of Parkinson’s Disease
  John E. Duda and Dennis W. Dickson
• Neurophysiology of the Motor Disorder in Parkinson’s Disease
  Gaëtan Garraux and Mark Hallett
• Neurochemistry of Parkinson’s Disease: Dopamine
  L. Charles Murrin
• Pathophysiology of Parkinson’s Disease, Neurochemical Pathology: Other Neurotransmitters
  Yoshikuni Mizuno

• Theories of Pathogenesis
• Oxidative Stress
  Casey Cook and Leonard Petrucelli
• Mitochondrial Dysfunction
  Daniel G. Healy and A.H.V. Schapira
• Excitotoxicity
  Fabio Blandini
• Inflammation
  Roger Kurlan
• Protein Conformational and Metabolic Changes in Parkinson’s Disease
  Kevin St. P. McNaught and C. Warren Olanow
• Cell Death in Parkinson’s Disease
  Shankar Sadasivan, Ané Korff, Ciaran J. Faherty, and Richard Jay Smeyne

• Diagnosis of Parkinson’s Disease
• Differential Diagnosis of Parkinson’s Disease
  Serena W. Hung and Anthony E. Lang
• Neuroleptic-Induced Movement Disorders
  Manuchair Ebadi
• Clinical Diagnostic Criteria for Parkinson’s Disease
  Daniel Tarsy and Laurie Gordon
• Clinical Batteries and Biomarkers in the Diagnosis of Parkinson’s Disease
  Claire Henchcliffe and Un Kang
• Rating Scales
  Kathleen M. Shannon
• MR Imaging of Parkinsonism
  James B. Wood
• Molecular Imaging in Parkinson Disease
  Danna Jennings, David Russell, Ken Marek, and John Seibyl
• Positron Emission Tomography in Parkinson’s Disease
  Silke Appel-Cresswell, R. Nandhagopal, John R. Adams, and A. Jon Stoessl
• Transcranial Ultrasound in Parkinson’s Disease
  Daniela Berg, Bettina Faust, and Alexandra Gaenslen
• In Vivo Molecular Imaging in Parkinson’s Disease
  Sushil K. Sharma and Manuchair Ebadi
• Placebo Effect in Parkinson’s Disease
  Jayasri Srinivasan, Sarah C. Lidstone, Raúl de la Fuente-Fernández, and A. Jon Stoessl
• Treatment of Parkinson’s Disease with Anticholinergic Medications
  Duarte Machado and Bahman Jabbari
• Amantadine
  Kelly E. Lyons and Rajesh Pahwa
• MAO-B Inhibitors for the Treatment of Parkinson’s Disease
  John Bertoni
• Catechol-O-Methyltransferase Inhibitors in the Treatment of Parkinson’s Disease
  Mervat Wahba, Theresa A. Zesiewicz, and Robert A. Hauser
• Symptomatic Treatment of Parkinson’s Disease: Levodopa
  John L. Goudreau and J. Eric Ahlskog
• Dopamine Agonists in Parkinson’s Disease
  Joseph Jankovic and Toby C. Yaltho
• Non-Dopaminergic Drugs for Motor Symptoms
  Pierre R. Burkhard and Francois J.G. Vingerhoets
• Stereotactic Ablative Procedures for Intractable Parkinson’s Disease
  Marco Sassi and Michael S. Okun
• Deep Brain Stimulation Surgery
  Ryan J. Uitti, Yashiko Baba, and Robert E. Wharen Jr.
• Neurotransplantation in the Treatment of Parkinson’s Disease
  Penelope Hallett and Ole Isacson
• Role of Physical Therapy in Management of Parkinson’s Disease
  Rose Wichmann
• Speech Therapy in the Treatment of Parkinson’s Disease
  Shimon Sapir, Lorraine Ramig, and Cynthia Fox
• Dysphagia in Parkinson’s Disease
  Lisa A. Newman
• Restorative and Functional Occupational Therapy in Parkinson’s Disease
  Surya Shah
• Neurologic Music Therapy: A Modality to Address the Diverse Needs of People with Parkinson’s Disease
  Sandra L. Holten
• Dance for Persons with Parkinson’s Disease*
  Olie Westheimer
• Pathogenesis of Motor Response Complications in Parkinson’s Disease: "Mere Conjectural Suggestions" and Beyond
  Leo Verhagen Metman and Christina L. Vaughan
• Treatment of Early Parkinson’s Disease
  John C. Morgan and Kapil D. Sethi
• Treatment of Moderate Parkinson’s Disease
  John E. Duda and Matthew B. Stern
• Management of Advanced Parkinson’s Disease
  Grace S. Lin Liang and James W. Tetrud
• Role and Design of Clinical Trials for Parkinson’s Disease
  Andrew Siderowf and Stanley Fahn
• Future Symptomatic Therapy in Parkinson’s Disease
  Ruth Djaldetti, Shlomit Yust-Katz, and Eldad Melamed
• Calcium Influx, Free Radicals, and Aging: A Metabolic Burden Linked to Neuronal Loss in Parkinson’s Disease
  Javier Sanchez-Padilla, Jaime N. Guzman, and D. James Surmeier
• Therapeutic Potential of Exercise in Parkinson’s Disease
  Brian K. Schilling
• Gene Therapy for Parkinson’s: Disease from Bench to Bedside
  Fredric P. Manfredsson, Aaron C. Rising, M. Angela Cenci, Carmen S. Peden, and Ronald J. Mandel
• Translating Stem Cell Biology to Regenerative Medicine for Parkinson’s Disease
  Florian A. Siebzehnrubl and Dennis A. Steindler
• Alternative Drug Delivery in the Treatment of Parkinson’s Disease
  Pierre J. Blanchet
• Economics of Parkinson’s Disease
  Jessica Mastalski, Robert G. Holloway, and Katia Noyes
• Informal Caregiving: An Essential Part of the Team
  Carmen Dyck and Susan M. Calne
• Driving in Parkinson’s Disease
  Ergun Y. Uc
• Evolution and Potential of the National Parkinson’s Organizations: A Brief Overview
  Ruth A. Hagestuen
• Comprehensive Parkinson’s Disease Care in Complex Environments
  Elaine Cohen, Monique Giroux, Ruth A. Hagestuen, and Gladys Gonzalez-Ramos

• Index