Dermatokinetics of Therapeutic Agents

Description

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.

Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents.

Topics include:

• Theoretical Models for Dermatokinetics of Therapeutic Agents
• Drug Delivery Approaches to Modulate Dermatokinetics of Drugs
• Conventional Methods of Cutaneous Drug Sampling
• Cutaneous Microdialysis
• Sampling Substrates by Skin Permeabilization
• Spectroscopic Techniques in Dermatokinetics Studies
• Regulatory Perspective of Dermatokinetic Studies

Features

• Provides a general overview of the theoretical aspects of dermatokinetics
• Addresses the impact of a drug delivery system on the dermatokinetics of drugs
• Examines the methods and models used in dermatokinetic studies of therapeutic agents
• Includes illustrations to clarify concepts

Table of Contents

• Introduction to Dermatokinetics
• Skin Tissue and the Extracellular Fluid
• Fate of Therapeutic Agents in Skin
• Distribution of Drugs in the Skin
• Biochemistry of Cutaneous Tissue and Biotransformation of Drugs
• Dermatokinetics of Drugs and Dermatopharmacology
• Dermatokinetics of Drugs and Dermatotoxicology
• Theoretical Models for Dermatokinetics of Therapeutic Agents
• Introduction to Fundamentals of Pharmacokinetics
• Theoretical Models of Dermatokinetics of Drugs
• Two Compartment Model
• Physiologically Based Pharmacokinetic Model
• Drug Delivery Approaches to Modulate Dermatokinetics of Drugs
• Drug Delivery Systems and Dermatokinetics
• Salts, Prodrugs, and Complexes
• Physiological Approaches to Dermatokinetics of Drugs
• Cutaneous Sustained Release Drug Delivery Systems
• Carrier Mediated Drug Delivery Systems
• Physically Mediated Drug Delivery
• Target Deliver to Skin
• Conventional Methods of Cutaneous Drug Sampling
• Introduction to Drug Sampling Techniques and their use in Dermatokinetics Studies of Drugs
• Tape Stripping Method of Drug Sampling
• Skin Biopsy Sampling
• Skin Blister Fluid Sampling
• Cutaneous Microdialysis
• Basics of Cutaneous Tissue Microdialysis and Methods of Probe Calibration
• Probes Used in Cutaneous Microdialysis
• Common Procedural Issues, Troubleshooting, and Optimization Approaches
• Sampling Substrates by Skin Permeablization
• Introduction to Transcutaneous Sampling of Drugs
• Reverse Iontophoresis
• Electroporation Mediated Drug Sampling
• Sonoporesis Mediated Sampling
• Cutaneous Sampling by Microneedles
• Spectroscopic Techniques in Dermatokinetics Studies
• Introduction to Fundamentals of Spectroscopic Techniques Used in Dermatokinetics Studies
• Fluorescence Detection Skin Drug Levels
• ATR FTIR Detection of Drug in Skin
• Raman Spectroscopy
• Dermatokinetics of Gene Therapeutics
• Gene Therapeutics and Cutaneous Gene Therapy
• Pharmacogenetics of Gene Therapeutics in Skin
• Regulatory Perspective of Dermatokinetic Studies
• Skin Bioavailability and Bioequivalence Studies
• FDA Guidelines for Dermatokinetic Studies

Authors

S. Narasimha Murthy is an Assistant Professor of Pharmaceutics at the University of Mississippi.