Biomaterials and Regenerative Medicine in Ophthalmology

SUMMARY

With an increasingly aged population, eye diseases are becoming more widespread. Biomaterials have contributed in recent years to numerous medical devices for the restoration of eyesight, improving many patients’ quality of life. This book provides readers with a definitive coverage of biomaterials and techniques used for the repair and regeneration of the eye. Initial chapters review applications in the anterior segment of the eye. A second group of chapters discuss applications in the posterior segment of the eye. The final group of chapters covers other pertinent topics such as hydrogel sealants for wound repair in ophthalmic surgery, orbital enucleation implants, and polymeric materials for orbital reconstruction.

TABLE OF CONTENTS

Part 1 Materials, properties, and considerations.

• Physiochemical properties of hydrogels.
• Surface modification.
• Engineering the corneal epithelial cell response.
• Biocompatibility testing.

Part 2 Applications.

• Extended wear contact lenses.
• Superior oxygen permeation.
• Corneal replacements.
• Synthetic corneal replacements.
• Intraocular lens materials.
• Injectable intraocular lens materials.
• Opacification and degradation of implanted intraocular lenses.
• Design of in-situ forming hydrogels as vitreous substitutes.
• Intraocular sustained drug delivery.
• Glaucoma drainage implants.
• Socket implants.

Part 3 Ophthalmic regenerative medicine.

• Tissue engineering of the cornea.
• Wound healing in the cornea and the effect of foreign bodies.
• Reconstruction of the ocular surface.
• Regenerative medicine of the cornea involving stem cell therapy.
• Tissue engineering of the lens.
• Retinal repair and regeneration.
• Development of tissue-engineered membranes.
• Hydrogel sealants for wound repair.
• Orbital reconstruction.