Recombinant Dna. Genes and Genomes. a Short Course.

Description

The third edition of the landmark text Recombinant DNA offers an authoritative, accessible, and engaging introduction to modern, genome–centered biology from its foremost practitioners. The new edition explores core concepts in molecular biology in a contemporary inquiry–based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA. As a result, students learn in a compelling way how working scientists make real high–impact discoveries.

The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large–scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease–causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.

Contents

FOUNDATIONS OF DNA
1. DNA Is the Primary Genetic Material
2. Information Flow from DNA to Protein
3. Control of Gene Expression
4. Basic Tools of Recombinant DNA
5. Fundamental Features of Eukaryotic Genes
6. A New Toolbox for Recombinant DNA
7. Mobile DNA Sequences in the Genome
8. Epigenetic Modifications of the Genome
9. RNAi Regulates Gene Action

FOUNDATIONS OF GENOMICS
10. Fundamentals of Whole-Genome Sequencing
11. How the Human Genome Was Sequenced

ANALYZING GENOMES
12. Comparing and Analyzing Genomes
13. From Genome Sequence to Gene Function

HUMAN GENOMICS
14. Finding Human Disease Genes
15. Understanding the Genetic Basis of Cancer
16. DNA Fingerprinting and Forensics
Figure Credits
Index