Cardiology Science and Technology

Description

Cardiology Science and Technology comprehensively deals with the science and biomedical engineering formulations of cardiology. As a textbook, it addresses the teaching, research, and clinical aspects of cardiovascular medical engineering and computational cardiology.

The books consists of two sections. The first section deals with left ventricular (LV) wall stress, cardiac contractility, ventricular remodeling, active wall stress and systolic pressure generation, and vector cardiogram characteristics, with applications in cardiology. The second section covers ECG signal analysis for arrhythmias detection, LV pumping (intra-LV, aortic and coronary flow) characteristics, and coronary bypass surgery design, with applications in cardiology and cardiac surgery.

This book is like an exciting train ride through the heart and into blood flows within its chamber, the coronary tree, the aorta, and finally into coronary flow and bypass grafting. The train starts from the heart’s central station and journeys through exciting places of heart wall stresses, cardiac contractility measures to characterize heart failure, and active stress generation to develop systolic heart pressure. We learn about cardiomyopathic heart remodeling and its surgical ventricular restoration, theory of ECG and vector cardiogram with medical applications, and heart rate variability signal processing to detect cardiac arrhythmias.

In the heart chamber, we witness the amazing intricate intra-ventricular flow patterns. Then, we study pressure pulse wave propagation into the aorta, determination of pulse wave velocity and arterial elasticity as a measure of arteriosclerosis. We climb into the mountainous coronary terrain and look at the fascinating scenery of coronary flows and myocardial perfusion that governs cardiac contractility. Finally, we arrive at coronary bypass grafting and witness the new sequential anastomosisdesign for enhanced patency.

This fascinating journey helps us to fully appreciate cardiology from the science, technology, engineering, and mathematics viewpoint. The book represents what can be termed as computational cardiology, and hence belongs to the emerging field of computational medicine.

Features

• Discusses the bioengineering features and heart function models in cardiology
• Covers left ventricular wall stress, cardiac contractility, myocardial fibers’ contraction causing generation of systolic pressure
• Develops the theory of ECG and vector cardiogram with medical applications, heartrate variability integrated index for more accurate detection of arrhythmias
• Explains LV perfusion, and modeling of intra-LV flow, aortic pulse wave propagation, coronary blood flow and coronary bypass surgery design

Contents

LEFT VENTRICULAR WALL STRESS, CARDIAC CONTRACTILITY, ACTIVE WALL STRESS AND SYSTOLIC PRESSURE GENERATION, CARDIOMYOPATHIC HEART REMODELLING, VECTOR CARDIOGRAM CHARACTERISTICS, WITH APPLICATIONS IN CARDIOLOGY

Left Ventricular Wall Stress Compendium to Analyze Heart Function
Dhanjoo N. Ghista, Harold Sandler, and Israel Mirsky

Cardiac Function Assessment in Filling and Systolic Phases: Passive and Active Elastances of the Left Ventricle
Dhanjoo N. Ghista, Liang Zhong, and Eddie Y.K. Ng

Novel Cardiac Contractility Index and Ventricular-Arterial Matching Index to Serve as Markers of Heart Failure
Liang Zhong, Dhanjoo N. Ghista, Ghassan S. Kassab, and Ru San Tan

Cardiomyopathy Effect on Left Ventricle Function (Shape and Contractility) and Improvement after Surgical Ventricular Restoration
Dhanjoo N. Ghista, Yi Su, Liang Zhong, Ru San Tan, and Ghassan S. Kassab

Cardiac Contractility Measures for Left Ventricular Systolic Functional Assessment in Normal and Diseased Hearts
Dhanjoo N. Ghista, Liang Zhong, Thu-Thao Le, and Ru San Tan

Analysis for Left Ventricular Pressure Increase during Isovolumic Contraction due to Active Stress Development in the Myocardial Fibers 
Dhanjoo N. Ghista, Li Liu, and Foad Kabinejadian

Left Ventricular Remodeling due to Myocardial Infarction and its Surgical Ventricular Restoration
Dhanjoo N. Ghista, Yi Su, Liang Zhong, Ghassan S. Kassab, and Ru San Tan

Vector Cardiogram Theory and Clinical Application
Dhanjoo N. Ghista and Thurairaj Nagenthiran

ECG SIGNAL ANALYSIS AND LEFT VENTRICULAR PUMPING (INTRA-VENTRICULAR, AORTIC AND CORONARY FLOW) CHARACTERISTICS, CORONARY BYPASS SURGERY DESIGN, WITH APPLICATIONS IN CARDIOLOGY AND CARDIAC SURGERY

ECG Waveform Analysis and Heart Rate Variability Signal Analysis to Detect Cardiac Arrhythmias
Subbhuraam Vinitha Sree, Dhanjoo N. Ghista, G. Swapna, U. Rajendra Acharya

Left Ventricular Blood Pump Analysis: Intra-LV Flow Velocity and Pressure, for Coronary Bypass Surgery Candidacy 
Dhanjoo N. Ghista, Foad Kabinejadian, K. Subbaraj, and Ernie Fallen

Cardiac Perfusion Analysis and Computation of Intra-Myocardial Blood Flow Velocity and Pressure Patterns
Dhanjoo N. Ghista, Eddie Y.K. Ng, Ru San Tan, Jian-Jun Shu, and Reginald Jegathase

Arterial Pulse Wave Propagation Analysis: Determination of Pulse Wave Velocity and Arterial Properties
Dhanjoo N. Ghista and Foad Kabinejadian

Simulation of Blood Flow in Idealized and Patient-Specific Coronary Arteries with Curvatures, Stenoses, Dilatations, and Side-Branches
Kelvin Wong, Dhanjoo N. Ghista, Jianhuang Wu, and Guiying Li

Intra-Left Ventricular Flow Velocity Distributions, based on Color Doppler Echo Vector Flow Mapping of Normal Subjects and Heart Failure Patients
Thu-Thao Le, Dhanjoo N. Ghista, Ru San Tan, and Sridhar Idapalapati

Coronary Blood Flow Analysis and Coronary Bypass Graft Flow and Design
Foad Kabinejadian, Yunlong Huo, Dhanjoo N. Ghista, and Ghassan S. Kassab

Coupled Sequential Anastomotic Bypass Graft (CSABG) Design
Foad Kabinejadian, Dhanjoo N. Ghista, and Leok Poh Chua

Author

Dhanjoo N. Ghista, PhD, University 2020 Foundation, Massachusetts, USA