Randomized Clinical Trials of Nonpharmacological Treatments

Description

Nonpharmacological Treatments include a wide variety of treatments such as surgery, technical procedures, implantable devices, nonimplantable devices, rehabilitation, psychoteherapy, and behavioral interventions. This book focuses on the methods of assessing nonpharmacological treatments, highlighting specific issues and discussing all possible design of trials. It provides practical examples to underline the issues and solutions in assessing nonpharmacological treatment in trials. Arguably the first book to exclusively explore this topic, it discusses various categories of treatments from surgical procedures to psychotherapy.

Table of Contents

Assessing Nonpharmacological Treatments: Theoretical Framework

Blinding in Nonpharmacological Randomized Controlled Trials
Isabelle Boutron and Philippe Ravaud
Placebo in Nonpharmacological Randomized Trials
Asbjørn Hróbjartsson and Franklin G. Miller
Complexity of the Intervention
Patricia Yudkin, Rafael Perera, and Paul Glasziou
Learning Curves
Jonathan A. Cook and Craig R. Ramsay
Clustering Effects in RCTs of Nonpharmacological Interventions
Jonathan A. Cook
Assessment of Harm
Panagiotis N. Papanikolaou and John P.A. Ioannidis
External Validity and Applicability of Nonpharmacological Trials
Isabelle Boutron and Philippe Ravaud
Assessing Nonpharmacological Interventions in Cluster Randomized Trials
Bruno Giraudeau and Philippe Ravaud
Expertise-Based Trials
Jonathan A. Cook
Pragmatic Trials and Nonpharmacological Evaluation
Merrick Zwarenstein
Preference Trials
Arthur Kangombe, Helen Tilbrook, and David Torgerson
Nonrandomized Studies to Evaluate the Effects of a Nonpharmacological Intervention
Barnaby C. Reeves
Methodological and Reporting Considerations for Systematic Reviews of Nonpharmacological Interventions
Alexander Tsertsvadze, Larissa Shamseer, and David Moher
Accounting for the Complexity of the Intervention in Nonpharmacological Systematic Reviews
Sasha Shepperd and Simon Lewin
Reporting Guidelines for Nonpharmacological Trials
Isabelle Boutron and Philippe Ravaud

Assessing Nonpharmacological Treatments: Practical Examples

Assessing Cardiothoracic Surgery: Practical Examples
Tom Treasure and Martin Utley
Assessing Obstetrics and Gynecology: Practical Examples
Vincenzo Berghella and Jorge E. Tolosa
Assessing Lower Limb Arthroplasty: Practical Examples
David Biau and Remy Nizard
Assessing Radiation Therapy: Practical Examples
Hidefumi Aoyama
Assessing Electroconvulsive Therapy: Practical Examples
Keith G. Rasmussen
Assessing Acupuncture: Practical Examples
Hugh MacPherson
Assessing Orthosis: Practical Examples
Katherine Sanchez, Claire Jourdan, François Rannou, and Serge Poiraudeau
Assessing Rehabilitation: Practical Examples
Nadine Elizabeth Foster
Assessing Psychotherapy: Practical Examples
Paula P. Schnurr
Assessing Psychosocial Interventions for Mental Health: Practical Examples
Graham Thornicroft and Michele Tansella
Assessing Behavioral Change Interventions for Mental Health: Practical Examples
Charles Abraham
Assessing Hypnotherapy: Practical Examples
Isabelle Marc

Index