Preclinical Drug Development

An essential resource for medicinal chemists, biologists, and any specialist involved in the drug development sciences. Discussing the A to Z’s of preclinical drug development, this text includes the latest industry trends and regulatory expectations and requirements. Recent cases studies and drug development simulation methods are included to illustrate emerging techniques and strategies.

New chapters cover:

• pharmacokinetics
• modeling and simulation
• formulation and routes of administration
• toxicity evaluations
• assessment of drug absorption and metabolism
• interspecies scaling

Updated topics include:

• lead molecule selection and optimization via profiling
• screening using in silico and in vitro toxicity evaluations
• preclinical pharmacokinetic-pharmacodynamic modeling
• International Conference on Harmonization preclinical guidelines
• experimental methods for studying membrane drug transport