Toxicology of the Skin (Target Organ Toxicology Series, Vol. 29)

Description

Exploring the skin’s ability to protect and form a barrier against the external environment, Dermal Toxicology is an innovative text with a modern approach to the study of how chemicals modify the properties of the skin barrier and how the skin barrier reacts and adapts to these chemicals.

Key topics include:

• stratum corneum (SC) formation and maturation, barrier repair mechanisms, clinical manifestation of disease, and topical drug delivery and bioavailability
• emerging epidermal barrier functions for permeability barrier homeostasis, epidermal transporters and skin metabolism, as well as antimicrobial and defense mechanisms
• biomechanics, including keratin remodeling, SC biomechanics, and the role of flexion in skin absorption and toxicity
• chemicals associated with skin toxicity and absorption, such as specific cosmetics, irritants, chemical toxicants, drugs, drug delivery methods, and nanoparticles