Pharmacology and Therapeutics. Principles to Practice

Description

Pre-eminent authorities examine everything you need to know about pharmacology AND therapeutics for all of today's drugs - from the underlying science through innovation, translation, regulation, and clinical implementation. Evidence-based therapeutic guidelines facilitate decision making; and coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine keeps you at the forefront of the latest developments. Reference is easy, thanks to the book's logical, user-friendly format, as well as access to the complete contents online. This Premium Edition also offers regular online updates, an online drug database, downloadable illustrations, and much more. In print and on the web, you'll have the answers to every vital question at your fingertips!

Reviews

"This is an outstanding textbook that connects the recent advances in basic principles with the practice of medicine. It is a must-have book for those involved in drug discovery, translational research, and the teaching of evidence-based medicine."
--Thomas L. Pazdernik, PhD (University of Kansas Medical Center)

Key Features

• Provides regular online updates reflecting the latest genetic discoveries, clinical trials, therapeutic guidelines, and other critical developments.
• Features a continuously updated online drug database for quick, current answers on uses, dosages, indications, contraindications, and more.
• Features a logical organization (by body system, rather than by drug class) and an exceptionally user-friendly format so you can find the clinically actionable information you need more easily.
• Offers evidence-based therapeutic guidelines to help you make sound clinical decisions.
• Includes cutting-edge coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine across medical specialties.
• Examines nutrition, complementary and alternative medicines, neutraceuticals, and dietary supplements, allowing you to effectively counsel patients and avoid dangerous drug interactions.
• Includes access to the complete contents of the book online, fully searchable, for rapid, efficient consultation from any computer.
• Allows you to download hundreds of full-color illustrations for use in electronic presentations.

Table of Contents

PART I: PRINCIPLES

Section 1: Pharmacotherapeutic Continuum

1 Drug Discovery
2 Drug Development
3 Regulations and Pharmacovigilence
4 Evidence-Based Drug Utilization

Section 2: Molecular Pharmacology

5 Drug-Receptor Interactions
6 Signal Transduction
7 ";Cell Cycle Pharmacology, Antiproliferation, and Apoptosis";

Section 3: Systems Pharmacology

8 Neurotransmitters
9 Autonomic Pharmacology
10 Fluid and Electrolyte Homeostasis
11 Inflammation and Immunomodulation
12 Pharmacobiology of Infections

Section 4: Clinical Pharmacology

13 Pharmacokinetics
14 Pharmacodynamics
15 Pharmacogenetics and Pharmacogenomics
16 Heterogenity of Drug Responses and Individualization of Therapy
17 Pediatric Pharmacology
18 Gender Influences on Pharmacology
19 Pharmacology Across the Aging Continuum
20 Adverse Drug Reactions and Interactions
21 Therapeutic Monitoring

PART II: Practice

Section 5: Cardiovascular Therapeutics

22 Hypertension
23 Dyslipidemias
24 Coronary Artery Disease
25 Rhythm Disorders
26 Heart Failure

Section 6: Pulmonary Therapeutics

27 Pulmonary Arterial Hypertension
28 Asthma and Chronic Obstructive Pulmonary Disease

Section 7: Renal Therapeutics

29 Renal Insufficiency
30 Voiding Dysfunction

Section 8: Gastroenterologic Therapeutics

31 Acid Reflux and Ulcer Disease
32 Motility Disorders
33 Inflammatory Bowel Diseases
34 Hepatic Cirrhosis
35 Infectious Hepatitis

Section 9: Endocrinologic Therapeutics

36 Obesity and Nutrition
37 Diabetes Mellitus
38 Disorders of the Thyroid
39 Disorders of Calcium Metabolism and Bone Mineralization
40 Disorders of the Hypothalamic Pituitary Axis
41 Adrenal Disorders
42 Reproductive Health

Section 10: Neuropharmacologic Therapeutics

43 Alzheimer's Disease and Dementias
44 Parkinson's Disease
45 Seizure Disorders
46 Multiple Sclerosis
47 Dysautonomias
48 Headache
49 Stroke

Section 11: Psychopharmacologic Therapeutics

50 Obsessive-Compulsive Disorders
51 Attention-Deficit/Hyperactivity Disorder
52 Anxiety
53 Depression and Bipolar Disorders
54 Psychosis and Schizophrenia
55 Drug Addiction
56 Nicotine Dependence
57 Insomnia (Narcolepsy)-Related Disorders

Section 12: Opthalmologic Therapeutics

58 Drugs in Ophthalmology

Section 13: Anesthesia

59 Local Anesthesia
60 General Anesthesia and Sedation
61 Treatment of Pain

Section 14: Hematologic Therapeutics

62 Anemias and Cytopenias
63 Disorders of Hemostasis and Thrombosis

Section 15: Oncologic Therapeutics

64 Lung Cancer
65 Breast Cancer
66 Hematologic Malignancies
67 Prostate Cancer
68 Colon Cancer
69 Melanoma

Section 16: Dermatologic Therapeutics

70 Acne
71 Psoriasis
72 Dermatitis

Section 17: Rheumatologic Therapeutics

73 Osteoarthritis
74 Rheumatoid Arthritis
75 Gout
76 Systemic Lupus Erythmatosus

Section 18: Therapy of Infectious Diseases

77 Influenza and Viral Respiratory Infections
78 Community-Acquired Pneumonia
79 Tuberculosis
80 Bacterial Meningitis
81 Endocarditis
82 Malaria
83 Protozoan and Helminthic Infections
84 HIV Infection and AIDS
85 Sexually Transmitted Diseases

Section 19: Practical Therapeutics

86 Medical Toxicology and Antidotes
87 Over-the-Counter Medications
88 Prescription and Order Writing
89 Pharmacy and Therapeutics Committees and the Hospital Formulary

Section 20: Emerging Therapeutics

90 ";Complementary and Alternative Medicine, Nutraceuticals, and Dietary Supplements";
91 Vaccines
92 Transplant Medicine
93 Gene Therapy
94 Regenerative Medicine and Stem Cell Therapeutics

Author Information

By Scott A. Waldman, MD, PhD, FCP, Samuel M.V. Hamilton Professor of Medicine and Professor of Biochemistry and Molecular Pharmacology; Director of Clinical Pharmacology, Thomas Jefferson University Philadelphia, PA; and Andre Terzic, MD, PhD, Professor of Medicine, Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School; Vice-Chair Cardiovascular Research, Mayo Clinic, Mayo Foundation, Rochester, NY

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