Canine and Feline Dermatology Drug Handbook

Description

This comprehensive handbook summarizes dermatological drugs for feline and canine patients. It covers oral, topical and injectable medications suitable for cats and dogs. Vital information given for each drug includes: indications, contraindications, mechanism of action, dosage, formulations, side-effects, drug interactions and monitoring. Both American and European trade names are provided alongside generic names for ease of reference.

The book is divided into 4 sections. The first covers systemic dermatological agents. The second section presents topical dermatological agents. The third section covers allergen-specific immunotherapy. The fourth section lists dermatological conditions and the drugs commonly used to treat each disease, and directs the reader to the information on those drugs.

Canine and Feline Dermatology Drug Handbook is an essential reference for quick daily use in a clinical setting. Ideal for veterinarians in first opinion practice as well as those specializing in dermatology.

KEY FEATURES

• Lists drugs alphabetically for treatment of dermatological diseases in dogs and cats
• Covers oral, topical and injectable drugs
• Includes both American and European trade names
• Written by dermatology and pharmacology specialists
• Presented in an easy-to-use reference format

Table of Contents

• Preface, xiv
• Acknowledgments, xv
• Abbreviations and Conversions, xvi

Section 1: Systemic Drugs

(Note: the drugs in Section 1 are listed in alphabetical order in the text, not according to their functional and therapeutic classifi cation given in the contents list below; therefore, the page numbers are not listed in sequence for the drugs presented below.)

• Antibacterials, Beta-lactam
• Amoxicillin + clavulanic acid, 11
• Cefadroxil, 25
• Cefovecin sodium, 26
• Cefpodoxime proxetil, 28
• Cephalexin, 29
• Dicloxacillin sodium, 69
• Oxacillin sodium, 16
• Piperacillin sodium, 170
• Ticarcillin disodium + clavulanate potassium, 203
• Antibacterials, Fluoroquinolones
• Ciprofloxacin hydrochloride, 38
• Difloxacillin hydrochloride, 70
• Enrofloxacin, 78
• Marbofloxacin hydrochloride, 133
• Moxifloxacin, 153
• Norfloxacin, 160
• Orbifloxacin, 161
• Pradofloxacin, 176
• Antibacterials, Lincosamides
• Clindamycin hydrochloride/palmitate, 43
• Lincomycin hydrochloride, 124
• Antibacterials, Macrolides
• Azithromycin, 20
• Clarithromycin, 39
• Erythromycin, 81
• Antibacterials, Potentiated Sulfonamides
• Ormetoprim + sulfadimethoxine, 163
• Sulfadiazine/sulfamethoxazole + trimethoprim, 193
• Sulfasalazine, 195
• Antibacterials, Tetracyclines
• Doxycycline, 76
• Minocycline hydrochloride, 146
• Tetracycline hydrochloride, 199
• Antibacterials, Miscellaneous
• Chloramphenicol/chloramphenicol palmitate, 34
• Clofazimine, 45
• Dapsone, 62
• Ethambutol, 85
• Rifampin, 181
• Antifungals
• Amphotericin B, 13
• Caspofungin acetate, 23
• Fluconazole, 89
• Flucytosine, 91
• Griseofulvin, 96
• Iodide, potassium, 109
• Itraconazole, 112
• Ketoconazole, 117
• Posoconazole, 174
• Terbinafine hydrochloride, 198
• Voriconazole, 215
• Antihistamines
• Amitriptyline hydrochloride, 9
• Cetirizine hydrochloride, 31
• Chlorpheniramine maleate, 36
• Clemastine fumarate, 41
• Clomipramine hydrochloride, 46
• Cyproheptadine hydrochloride, 61
• Diphenhydramine hydrochloride, 72
• Doxepin hydrochloride, 75
• Fexofenadine hydrochloride, 88
• Hydroxyzine hydrochloride/palmoate, 100
• Loratadine, 128
• Trimeprazine tartrate + prednisolone, 177, 210
• Anti-inflammatory Agents
• Allopurinol, 4
• Colchicine, 50
• Cyclosporine, 56
• Dapsone, 62
• Doxycycline, 76
• Essential fatty acids, 83
• Hydroxychloroquine sulfate, 98
• Minocycline hydrochloride, 146
• Niacinamide, 157
• Pentoxifylline, 169
• Piroxicam, 171
• PO7P (Chinese herbal supplement), 173
• Sulfasalazine, 195
• Tepoxalin, 196
• Tetracycline hydrochloride, 199
• Anti-inflammatory Agents, Glucocorticoids
• Dexamethasone, 64
• Methylprednisolone/methylprednisolone acetate, 141
• Prednisone/prednisolone, 177
• Triamcinolone acetonide, 206
• Trimeprazine tartrate + prednisolone, 177, 210
• Antineoplastic/chemotherapeutic Agents
• Chlorambucil, 32
• Cyclophosphamide, 54
• Lomustine, 126
• Masitinib mesylate, 135
• Piroxicam, 171
• Toceranib phosphate, 204
• Antiparasitic Agents
• Doramectin, 73
• Ivermectin, 115
• Lufenuron ± milbemycin oxime, 131
• Meglumine antimoniate, 138
• Milbemycin oxime, 145
• Moxidectin, 151
• Nitenpyram, 159
• Selamectin, 182
• Sodium stibogluconate/sodium antimony gluconate, 187
• Spinosad ± milbemycin oxime, 190
• Antivirals
• Acyclovir, 3
• Famciclovir, 87
• Lysine (L-lysine), 132
• Behavior Modifying Drugs, Opioid Antagonists
• Naltrexone hydrochloride, 156
• Behavior Modifying Drugs, Selective Serotonin Reuptake Inhibitors
• Fluoxetine hydrochloride, 93
• Paroxetine hydrochloride, 167
• Sertraline hydrochloride, 186
• Behavior Modifying Drugs, Tricyclic Antidepressants
• Amitriptyline hydrochloride, 9
• Clomipramine hydrochloride, 46
• Doxepin hydrochloride, 75
• Hormones
• Corticotropin, 52
• Cosyntropin, 53
• Dexamethasone, 64
• Levothyroxine sodium, 122
• Megestrol acetate, 137
• Melatonin, 139
• Methylprednisolone/methylprednisolone acetate, 141
• Methyltestosterone, 144
• Misoprostol, 148
• Mitotane (o,p’-DDD), 150
• Prednisone/prednisolone, 177
• Selegiline hydrochloride, 184
• Somatotropin, 188
• Thyrotropin, 201
• Thyrotropin-releasing hormone, 202
• Triamcinolone acetonide, 206
• Trilostane, 208
• Immunomodulatory Agents, Immunostimulant
• Interferon alpha, recombinant human, 103
• Interferon gamma, recombinant canine, 105
• Interferon omega, recombinant feline, 107
• Levamisole hydrochloride, 121
• Propionibacterium acnes injection, 180
• Staphage lysate, 191
• Immunomodulatory Agents, Immunosuppressive
• Auranofin, 15
• Aurothiomalate, sodium, 16
• Azathioprine, 18
• Chlorambucil, 32
• Cyclophosphamide, 54
• Cyclosporine, 56
• Dexamethasone, 64
• Immunoglobulin, human intravenous (hIVIG), 102
• Leflunomide, 120
• Methylprednisolone/methylprednisolone acetate, 141
• Mycophenolate mofetil, 154
• Prednisone/prednisolone, 177
• Neuropathic, Analgesic Agent
• Gabapentin, 95
• Nutritional Supplements
• Amino acids, 8
• Essential fatty acids, 83
• Zinc, 217
• Retinoids, Synthetic
• Acitretin, 1
• Isotretinoin, 110
• Tranquilizers, CNS Depressants, Benzodiazepines
• Alprazolam, 6
• Clonazepam, 49
• Diazepam, 67
• Lorazepam, 129
• Oxazepam, 166
• Vitamins
• Calcitriol, 22
• Vitamin A, 212
• Vitamin E, 214

Section 2: Topical Agents Antipruritic Agents, Non-corticosteroid

• Aluminum acetate solution (Burow’s solution), 219
• Colloidal oatmeal, 221
• Diphenhydramine hydrochloride, 224
• Lidocaine ± prilocaine, 225
• Neutralized zinc, 227
• Pramoxine hydrochloride, 228
• Anti-Inflammatory Agents
• Corticosteroids
• Betamethasone, 231
• Hydrocortisone, 234
• Hydrocortisone aceponate, 239
• Isoflupredone acetate, 242
• Mometasone furoate monohydrate, 243
• Triamcinolone acetonide, 246
• Non-Corticosteroids
• Essential fatty acids, 249
• Phytosphingosine salicyloyl, 253
• Antimicrobials
• Antibacterial Agents
• Acetic acid/boric acid, 255
• Bacitracin, 257
• Benzoyl peroxide, 258
• Clindamycin, 260
• Fusidic acid, 262
• Gentamicin sulfate, 264
• Mupirocin (pseudomonic acid), 267
• Nitrofurazone, 268
• Silver sulfadiazine, 270
• Three point enzyme system, 271
• Antiseptic Agents
• Chlorhexidine gluconate, 273
• Chloroxylenol (PCMX), 281
• Ethyl lactate, 283
• Hypochlorous acid, 284
• Povidone iodine, 287
• Triclosan (irgasan), 289
• Antifungal Agents
• Clotrimazole, 290
• Enilconazole, 293
• Ketoconazole, 295
• Lime sulfur (sulfurated lime solution), 299
• Miconazole nitrate, 301
• Nystatin, 304
• Selenium sulfide, 307
• Terbinafine hydrochloride, 309
• Antiseborrheic Agents
• Phytosphingosine hydrochloride, 310
• Salicylic acid, 311
• Sulfur, precipitated, 314
• Tar, coal, 317
• Immunomodulatory Agents
• Imiquimod, 319
• Pimecrolimus, 321
• Tacrolimus, 322
• Retinoids
• Adapalene (retinoid analog), 324
• Tazarotene, 325
• Tretinoin (all-trans retinoic acid; vitamin A acid), 326
• Antiparasitic Agents
• Amitraz, 327
• Deltamethrin, 331
• Dinotefuran + pyriproxyfen, ± permethrin, 331
• Fipronil ± (S)-methoprene, 333
• Imidacloprid combinations, 336
• (S)-Methoprene combinations, 340
• Permethrin and permethrin combinations, 347
• Picaridin, 350
• Pyrethrin combinations, 352
• Pyriproxyfen combinations, 356
• Rotenone, 360
• Spinetoram, 360
• Miscellaneous
• All natural, 361
• Capsaicin, 364
• Dimethyl sulfoxide, 365
• Sunscreen, 367
• Otic Preparations
• General information, 369
• Ototoxicity, 369
• Ceruminolytic agents, 374
• Cleaning/drying agents, 376
• Antiseptic agents, 379
• Antibiotic potentiating agents, 381
• Corticosteroid preparations, 382
• Antibacterial preparations, 383
• Antifungal preparations, 384
• Corticosteroid + antimicrobial preparations, 385
• Antiparasitic preparations, 388
• Compounded antibiotic preparations, 391

Section 3: Allergen-Specific Immunotherapy

• Definition, 395
• Indications, 395
• Mechanism of action, 395
• Precautions and contraindications, 396
• Clinical efficacy, 396
• Time to efficacy and duration of therapy, 397
• Allergen selection, 397
• Administration route, 398
• Allergen vials and treatment protocols, 399
• Adverse effects, 401
• Concurrent therapy and drug interactions, 402
• Client education, 402
• Recheck evaluations and monitoring, 403

Section 4: Skin Diseases and Suggested Treatment Hypersensitivity Disorders

• Atopic dermatitis, 405
• Feline mosquito-bite hypersensitivity, 406
• Flea allergy dermatitis, 406
• Autoimmune Skin Diseases
• Discoid lupus erythematosus, 407
• Pemphigus foliaceus, 407
• Sterile Inflammatory/Immune-Mediated Skin Diseases
• Cutaneous vasculitis, 408
• Idiopathic sterile pyogranulomatous-granulomatous syndrome, 408
• Juvenile cellulitis, 409
• Reactive histiocytosis, 409
• Sebaceous adenitis, 409
• Sterile nodular panniculitis, 410
• Parasitic Skin Diseases
• Canine demodicosis, 410
• Canine sarcoptic mange, 411
• Cheyletiellosis, 411
• Feline demodicosis, 412
• Otodectic mange (otoacariosis), 412
• Fungal Skin Disorders
• Dermatophytosis, 412
• Malassezia dermatitis, 413
• Systemic fungal diseases, 413
• Endocrine Skin Disorders
• Canine alopecia X, 414
• Canine hyperadrenocorticism, 414
• Canine hypothyroidism, 415
• Keratinization Disorders
• Acne, 415
• Canine zinc-responsive dermatosis, 416
• Pyodermas
• Superficial pyoderma, 416
• Deep pyoderma, 417
• Miscellaneous
• Acral lick dermatitis, 418
• Canine familial dermatomyositis, 418
• Canine perianal fistulas, 419
• Canine symmetrical onychodystrophy, 419
• Feline eosinophilic granuloma complex, 420
• Feline psychogenic alopecia, 420

• References, 423
• Index, 435

Author Information

Sandra N. Koch is an Assistant Clinical Professor in Dermatology at the University of Minnesota, College of Veterinary Medicine. She is a Diplomate of the American College of Veterinary Dermatology

Sheila M. F. Torres is an Associate Professor in Dermatology at the University of Minnesota, College of Veterinary Medicine. She is a Diplomate of the American College of Veterinary Dermatology.

Donald C. Plumb was formerly Director of Pharmacy Services and Hospital Director at the University of Minnesota's Veterinary Medical Center. He is the author of Plumb's Veterinary Drug Handbook, now in its seventh edition.