Neurodegeneration. the Molecular Pathology of Dementia and Movement Disorders

TABLE OF CONTENTS

Part 1 Introduction: Basic Mechanisms of Neurodegeneration.

• 1. Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (Dennis Dickson).
• 2. Cell Death and Neurodegeneration (Violetta N. Pivtoraiko and Kevin A. Roth).
• 3. Oxidative Stress and Balance in Neurodegenerative Diseases (George Perry, Siddhartha Mondragón-Rodríguez, Akihiko Nunomura, Xiongwei Zhu, Paula I. Moreira and Mark A. Smith).
• 4. Protein Aggregation in Neurodegeneration (Adriano Aguzzi and Veronika Kana).
• 5. Protein Degradation in Neurodegeneration: The Ubiquitin Pathway (Lynn Bedford, Robert Layfield, Nooshin Rezvani, Simon Paine, James Lowe and R. John Mayer).
• 6. Genetics of Neurodegeneration (John Hardy).
• 7. Transgenic Animal Models of Proteinopathies (Naruhiko Sahara, Heather Melrose, Simon D’Alton and Jada Lewis).

Part 2 Alzheimer’s Disease and Aging.

• 8. Clinical Aspects of Alzheimer’s Disease (David Knopman).
• 9. Genetics of Alzheimer’s Disease (Lars Bertram and Rudolph E. Tanzi).
• 10. Neuropathology of Alzheimer’s Disease and its Variants (Charles Duyckaerts and Dennis Dickson).
• 11. Aß Amyloid Production (Colin L. Masters and Konrad Beyreuther).
• 12. Elimination of Amyloid-ß from the Brain, its Failure in Alzheimer’s Disease and Implications for Therapy (Roy O. Weller, Seth Love and James A.R. Nicoll).

Part 3 Tauopathies.

• 13. Introduction to the Tauopathies (Michel Goedert).
• 14. Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (Bernardino Ghetti, Zbigniew K. Wszolek, Bradley F. Boeve, Salvatore Spina and Michel Goedert).
• 15. Progressive Supranuclear Palsy and Corticobasal Degeneration (Dennis Dickson, Jean-Jaques Hauw, Yves Agid and Irene Litvan).
• 16. Pick’s Disease (David G. Munoz, Huw R. Morris and Martin Rossor).
• 17. Argyrophilic Grain Disease (Markus Tolnay and Heiko Braak).
• 18. Parkinsonism–Dementia Complex of Guam (Kiyomitsu Oyanagi, Tomoyo Hashimoto and Mineo Yamazaki).
• 19. Postencephalitic Parkinsonism (Kurt A. Jellinger).

Part 4 Synucleinopathies.

• 20. Introduction to [alpha]–Synucleinopathies (Maria Grazia Spillantini).
• 21. Parkinson’s Disease (Kurt A. Jellinger).
• 22. Dementia with Lewy Bodies and Parkinson’s Disease Dementia (Paul G. Ince).
• 23. Lewy Bodies in Conditions other than Disorders of [alpha]-Synuclein (Coro Paisán-Ruiz, Laura Parkkinen and Tamas Revesz).
• 24. Multiple System Atrophy (Janice L. Holton, Andrew J. Lees and Tamas Revesz).

Part 5 Trinucleotide Repeat Disorders.

• 25. Introduction to Trinucleotide Repeat Diseases (H. Brent Clark).
• 26. Huntington’s Disease (John C. Hedreen and Raymund A.C. Roos).
• 27. Spinocerebellar Ataxias (Hidehiro Mizusawa, H. Brent Clark and Arnulf H. Koeppen).
• 28. Friedreich’s Ataxia (Arnulf H. Koeppen).
• 29. Dentatorubral-pallidoluysian Atrophy (Hitoshi Takahashi, Mitsunori Yamada and Shoji Tsuji).
• 30. Spinal and Bulbar Muscular Atrophy (Gen Sobue, Hiroaki Adachi and Masahisa Katsuno).

Part 6 Prion Disorders.

• 31. Introduction to Prion Disorders (Adriano Aguzzi and Veronika Kana).
• 32. Sporadic Creutzfeldt–Jakob Disease (Herbert Budka, Mark W. Head, James W. Ironside, Pierluigi Gambetti, Piero Parchi and Fabrizio Tagliavini).
• 33. Genetic Creutzfeldt–Jakob Disease (Piero Parchi, Pierluigi Gambetti and Sabina Capellari).
• 34. Fatal Familial and Sporadic Insomnia (Piero Parchi, Sabina Capellari and Pierluigi Gambetti).
• 35. A New Prion Disease: Protease-Sensitive Prionopathy (Pierluigi Gambetti, Gianfranco Puoti, Qingzhong Kong and Wenquan Zou).
• 36. Variant Creutzfeldt–Jakob Disease (James W. Ironside, Mark W. Head and Robert G. Will).
• 37. Gerstmann–Sträussler–Scheinker Disease (Bernardino Ghetti, Fabrizio Tagliavini, Gabor Kovacs and Pedro Piccardo).
• 38. Kuru (Catriona Ann McLean).
• 39. Iatrogenic Creutzfeldt–Jakob Disease (James W. Ironside, Richard S.G. Knight and Mark W. Head).

Part 7 Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease.

• 40. Introduction (James Lowe).
• 41. Frontotemporal Lobar Degeneration with TDP-43 Pathology (Ian R.A. Mackenzie and Manuela Neumann).
• 42. Neuronal Intermediate Filament Inclusion Disease (Nigel J. Cairns).
• 43. Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions (Manuela Neumann and Ian R.A. Mackenzie).
• 44. Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy (Michael J. Strong, Tibor Hortobágyi, Koichi Okamoto and Shinsuke Kato).

Part 8 Other Neurodegenerative Disorders.

• 45. Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease (John E. Duda).
• 46. Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia (Tamas Revesz, Agueda Rostagno, Gordon Plant, Tammaryn Lashley, Blas Frangione, Jorge Ghiso and Janice L. Holton).
• 47. Neurodegeneration with Brain Iron Accumulation (John E. Duda and Kurt A. Jellinger).
• 48. Familial Encephalopathy with Neuroserpin Inclusion Bodies (Richard L. Davis).
• 49. Hereditary Ferritinopathies (Ruben Vidal, Marie Bernadette Delisle, Olivier Rascol and Bernardino Ghetti).