Immunotherapy in Transplantation. Principles and Practice

Description

This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.

Contents

• List of Contributors.
• Preface.
• Section 1: Transplantation Immunobiology.
• 1. The Immune Response to a Transplanted Organ: An Overview (Fadi G. Lakkis).
• 2. Antigen Presentation in Transplantation (Martin H. Oberbarnscheidt and Fadi G. Lakkis).
• 3. The T Cell Response to Transplantation Antigens (Didier A. Mandelbrot, Bryna Burrell, Mohamed H. Sayegh and Peter S. Heeger).
• 4. The B Cell Response to Transplantation Antigens (Roger Sciammas, Anita S. Chong, Robert B. Colvin).
• 5. The Innate Response to a Transplanted Organ (Daniel R. Goldstein and Laurence A. Turka).
• 6. Regulation of the Alloimmune Response (Kathryn J Wood and Terry B Strom).
• Section 2: Transplantation Clinical Pharmacology.
• 7. Pharmacokinetics (Raman Venkataramanan).
• 8. Therapeutic Drug Monitoring for Immunosuppressive Agents (Michael C. Milone and Leslie M. J. Shaw).
• 9. Pharmacometrics: Concepts and Applications to Drug Development (Mallika Lala and Jogarao V. S. Gobburu).
• 10. Pharmacogenomics and Organ Transplantation (Gilbert J. Burckart and Richard M. Watanabe).
• 11. Study Design/process of development: Clinical studies (Richard D. Mamelok).

• Section 3: Agents.

• 12. Corticosteroids (Olivia Blume, Sarah E. Yost and Bruce Kaplan).
• 13. Azathioprine (Barry J. Browne).
• 14. Pharmacokinetic and Pharmacodynamic Properties of Mycophenolate (David Hager, Arjang Djamali, Bruce Kaplan).
• 15. Cyclosporine: Molecular Action to Clinical Therapeutics (Bradford Strijack and Paul A. Keown).
• 16. Tacrolimus (William E. Fitzsimmons).
• 17. Inhibitors of Mammalian Target of Rapamycin (Barry D. Kahan).
• 18. Inhibitors Targeting JAK3 (Gary Chan, Paul S. Changelian).
• 19. Cyclophosphamide (John J. Curtis).
• 20. Application of antisense technology in medicine (Stanislaw M. Stepkowski, Beata Mierzejewska, Frank C. Bennett).
• 21. The role of ganciclovir in transplantation (Lyndsey J. Bowman and Daniel C. Brennan).
• 22. Transplantation Immunotherapy with Anti-Thymocyte Globulin (ATG) (John L. Dzuris, Christian Bloy, Melanie Ruzek, John M. Williams).
• 23. The Role of Alemtuzumab in Solid Organ Transplantation (Avinash Agarwal, David Bruno and Stuart J. Knechtle).
• 24. Rituximab, an anti-CD20 monoclonal antibody (Mark D. Pescovitz).
• 25. The Anti-Interleukin 2 Receptor Antibodies (Muna Alnimri and Flavio Vincenti).
• 26. Infliximab/ Anti-TNF (Marina Vardanyan, Edward C. Parkin, Horacio L. Rodriguez Rilo).
• 27. CTLA4-Ig (Sarah E. Yost and Bruce Kaplan).
• 28. Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade (Swetha K. Srinivasan, Helen L. Triemer, Allan D. Kirk).
• 29. Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and Inflammation with Applications in Solid Organ Transplantation (Stanley C. Jordan, Mieko Toyoda, Joseph Kahwaji, Alice Peng and Ashley A. Vo).
• Index.