Laboratory Hematology Practice

Description

Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.

Table of Contents

• Contributors
• Preface
• Abbreviations

I Cellular Analysis

1. Historical Perspective on Cellular Analysis, (Elkin Simson)
2. Cellular Morphologic Analysis of Peripheral Blood, (Powers Peterson, Sheila McNeill, and Gene Gulati)
3. Automated Cell Analysis: Principles, (Bruce H. Davis and Patrick W. Barnes)
4. Differential Leukocyte Analysis, (Marie-Christine Béné and Francis Lacombe)
5. Automated Platelet Analysis, (Carol Briggs and Samuel J. Machin)
6. Method Standardization in Cellular Analysis, (Ian Giles & Richard Kendall)
7. Spurious counts and spurious results on hematology analyzers: platelets, (Marc Zandecki, Franck Genevieve, Jérémie Gérard, and Alban Godon)
8. Spurious Counts and Spurious Results on Hematology Analyzers: White Blood Cells, Red Blood Cells, Hemoglobin, Red Cell Indices, and Reticulocytes, (Marc Zandecki, Franck Genevieve, Jérémie Gérard, and Alban Godon)
9. Evaluation of Hematology Analyzers, (Carol Briggs)

II Flow Cytometry in Hematologic Diagnosis

10. Flow Cytometric Specimen Collection, Processing, and Reporting, (Maryalice Stetler-Stevenson, Bruce Greig, Constance Yuan)
11. Validation and Quality Control in Clinical Flow Cytometry, (Norman B. Purvis and Teri Oldaker)
12. A New Paradigm for Cytometric Analysis, (C. Bruce Bagwell)

III Molecular Diagnostics

13. Sample Collection, Processing, and Storage for Molecular Genetic Testing, (Bobby L. Boyanton Jr. and Domnita Crisan)
14. Development of Amplification-Based Molecular Genetic Testing in Hematology, (Raymond R. Tubbs)
15. Single Nucleotide Polymorphisms in Molecular Diagnostics, (Gurunathan Murugesan, Seongsoo Jang, and Jin-Yeong Han)
16. Molecular Cytogenetic (FISH) Analysis of Hematolymphoid Disorders, (Mark A. Micale and Anwar N. Mohamed)
17. Immunoglobulin and T-Cell Receptor Gene Rearrangement Analysis for Diagnosis of Hematologic Malignancies, (Jacques J. M. van Dongen, Anton W. Langerak, and Tomasz Szczepan ski)
18. Minimal Residual Disease Detection in Acute Myeloid Leukemia by RQ-PCR and Multiparameter Flow Cytometry, (Wolfgang Kern and Susanne Schnittger)
19. Engraftment Analysis using Short Tandem Repeats following Allogeneic Hematopoietic Cell Transplantation, (Ilka Warshawsky and Hyun-Sook Chi)
20. Molecular Profiling Methods in the Diagnosis of Hematologic Disorders, (Annette S. Kim, Stephen R. Master, and Cherie H. Dunphy)
21. The Role of Classical Cytogenetics in Hematologic Diagnosis, (Kathleen Richkind)

IV Bone Marrow Analysis

22. Bone Marrow Processing and Normal Morphology, (Karl S. Theil)
23. Cytochemical, Immunocytochemical, Histochemical, and Immunohistochemical Staining of Bone Marrow and Peripheral Blood, (Alexandra Rice and Barbara J. Bain)
24. The Myeloproliferative Neoplasms, (Sindhu Cherian and Brent L. Wood)
25. Myelodysplastic Disorders, (Maryalice Stetler-Stevenson, Joseph A. DiGiuseppe, and Diane C. Arthur)
26. Acute Leukemias, (Joseph A. DiGiuseppe and Laila Mnayer)
27. Lymphoproliferative Disorders, (Robert W. Allan, Samer Z. Al-Quran, Ying Li, and Raul C. Braylan)
28. Plasma Cell Disorders, (Bill G. Richendollar and James R. Cook)
29. Diagnosis of Adult Mastocytosis: Role for Bone Marrow Analysis, (Luis Escribano, Andrés Garcia-Montero, Laura Sanchez-Muñoz, Cristina Teodosio, Ivan Alvarez-Twose, Maria Jara-Acevedo, José Mario Morgado, Julia Almeida, Alberto Orfao for the Spanish Network on Mastocytosis (REMA))
30. Paroxysmal Nocturnal Hemoglobinuria (PNH) Analysis, (Stephen J. Richards)

V Hemostasis and Thrombosis

31. Sample Collection and Processing in Hemostasis, (Dorothy M. Adcock)
32. Performance and Interpretation of Routine Coagulation Assays, (Kandice Kottke-Marchant)
33. Clotting Factors and Inhibitors: Assays and Interpretation, (Piet Meijer, H. W. Verbruggen, and Michael Spannagl)
34. Diagnosis of von Willebrand Disease, (Emmanuel J. Favaloro and Jerry Koutts)
35. Diagnosis of Fibrinolytic Disorders, (Wayne Chandler)
36. Laboratory Evaluation of Acquired Coagulation Disorders, (Richard A. Marlar and Katerine Seywerd)
37. Platelet Assays and Platelet Dysfunction, (Paul Harrison and David Keeling)
38. Thrombophilia: Assays and Interpretation, (Sophia Yohe and John Olson)
39. Lupus Anticoagulants, Antiphospholipid Antibodies, and Antiphospholipid Syndrome, (William L. Nichols, Kandice Kottke-Marchant, Marlies R. Ledford-Kraemer, Henry A. Homburger, Layna K. Cardel)
40. Heparin-Induced Thrombocytopenia, (Sixten Selleng and Andreas Greinacher)
41. Anticoagulant, Antiplatelet, and Thrombolytic Drugs, (Laura Green and Samuel J. Machin)
42. Guidelines for Evaluation of Coagulation Analyzers and Coagulation Testing, (Chris Gardiner)

VI Special Hematology Techniques

43. Essentials of Immunohematology, (A. Bradley Eisenbrey)
44. Analysis of Hemoglobinopathies, Hemoglobin Variants and Thalassemias, (Monica V. E. Gallivan and Piero C. Giordano)
45. Nutritional Anemia, (Ralph Green)
46. Hemolytic Anemias Associated with Disorders of Erythrocyte Membrane and Cytoskeleton Proteins, (May-Jean King, Lesley J. Bruce, Didier Dhermy)
47. Body Fluid Analysis, (David J. Blomberg, Katherine Galagan, and Eric F. Glassy)
48. Malaria Analysis, (Qigui Li, Peter J. Weina, and R. Scott Miller)
49. Erythrocyte Sedimentation Rate (ESR), (Josep M. Jou)

VII Point-of-Care Testing

50. Needs Analysis and Selection of Point-of-Care Testing Analyzers, (Albert Huisman)
51. Point-of-Care Testing in Hemostasis, (Steve Kitchen and Dianne Kitchen)
52. Point-of-Care Hematology Assays, (Albert Huisman)

VIII Management of Information

53. Laboratory Management, (Stefanie L. McFadden and Linda M. Sandhaus)
54. Hematology Quality Practices (George S. Cembrowski)
55. Digital Imaging in Hematology, (Danny Hsu and Szu-Hee Lee)

• Index

Author

Dr Kandice Kottke-Marchant, MD PhD, Section Head, Hemostasis and Thrombosis, Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA and President, International Society of Laboratory Hematology. She is also a Professor of Pathology at the Cleveland Clinic Lerner College of Medicine and an Adjunct Professor of Biomedical Engineering at Case Western Reserve University. She has published over 100 peer-reviewed publications in the field of haemostasis, is an international expert on platelet testing and aspirin resistance, and has served on review panels from the National Institutes of Health (NIH), College of American Pathologists (CAP), ISO/TC212 and North American Specialized Coagulation Laboratory Association (NASCOLA). She has been a driving force to increase the international visibility and impact of the ISLH. She has been responsible for running the ISLH annual Symposia since 2002. Due to her involvement in haemostasis and the ISLH, Dr. Kottke-Marchant will be uniquely positioned to serve as one of the co-Editors of the Textbook of Laboratory Hematology.

Elkin Simson, MD, PCAP, FACSP is the Medical Director of the Center for Clinical Laboratories and Hematology Laboratory at the Mount Sinai Hospital. He is also Associate Professor and Vice Chairman of the Department of Pathology at the Mount Sinai School of Medicine, New York, NY, USA. Dr. Simson was formerly the Vice-President for Medical and Scientific Affairs at Technicon Instruments Corporation, where he participated in the development of the first automated haematology analyzers to combine the CBC and WBC differential into a single instrument. Dr Simson is the Past President of the ISLH and is Vice-President of the International Council for Standardization in Hematology (ICSH). He has been Chairman of the Hematology Area Committee of NCCLS (now CLSI), a member of Council of the National Reference System for the Clinical Laboratory (NRSCL) and the Hematology and Quality Improvement Subcommittees of the NCCCLS. He was a member of the Hematology and Pathology Advisory Panel of the Food and Drug Administration (FDA). Due to his long-time involvement in haematology automation and standards organizations, Dr. Simson is an idea co-editor.

The proposed section editors are chosen from international experts in their respective fields; most have also been long-time ISLH members who have been faculty at one or more ISLH Symposia and who have been repeatedly recognized as outstanding speakers and contributors by the participants. Dr Bruce Davis is one of the co-founders of the ISLH and has a long history of involvement in developing automated cellular and flow cytometric technologies. Professor Alberto Orfao from Spain is one of the world’s foremost experts on flow cytometry. Professor Samuel Machin is currently President of the British Society of Haematology and is an international authority on haemostasis testing. Stefanie McFadden is a medical technologist who is sought after as a consultant for laboratory management and informatics issues.