This new textbook has an international authorship and is a practical, up-to-date
resource for clinicians responsible for the care of children with oncologic
and malignant hematologic disease. It is specifically designed for practicing
oncologists and hematologists, pediatricians with an interest in childhood cancer
and trainees seeking a systematic approach to these disorders. This new textbook
has an emphasis on the visual presentation and ease of reading of contemporary
and comprehensive information for children’s cancers and contains detailed
tables, fact boxes and illustrations.
The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sections are then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacology and the findings of clinical trials. For each area of science covered, key original references and reviews are highlighted to direct further reading.
Diagnostic, biological, and therapeutic issues are integrated into each tumor-specific chapter, with evidence supporting the current rationales for risk stratification and the development of novel therapies. A final section then explores supportive care, palliative care, late effects considerations and psychosocial issues as relate to children’s cancer.
Table of Contents
Scientific principles of childhood oncology and haematology.
Section One: Central Nervous System Tumours of Childhood.
1.1 Low and high-grade glioma.
1.3 Primitive neuroectodermal tumours.
1.4 Spinal cord tumours.
1.5 Miscellaneous tumours (Craniophyngioma, mixed neuronal tumours, rhabdoid tumour).
Section Two: Haematological Disorders.
2.1 Acute lymphoblastic leukaemia.
2.2 Acute myeloid leukaemia and myeloproliferative disorders.
2.3 Non-Hodgkins lymphoma.
2.4 Hodgkins disease.
Section Three: Solid Tumours of Childhood.
3.2 Renal tumours.
3.3 Soft tissue tumours.
3.4 Bone tumours.
3.5 Hepatic tumours.
3.6 Germ cell tumours.
3.8 Rare tumours.
Section Four: Supportive Care, Long-Term Issues and Palliative Care.
4.1 Supportive care in relation to the physical consequences of cancer therapy.
4.2 Supportive care in relation to the psychological and social consequences of cancer therapy.
4.3 Late effects in relation to non-CNS tumours.
4.4 Late effects in relation to CNS tumours.
4.5 Palliative care
Edward J. Estlin, BSc (Hons), PhD, MRCP, FRCPCH
Macmillan Consultant in Paediatric Oncology, Department of Paediatric Oncology, Royal Manchester Children’s Hospital, Manchester, UK
Richard J. Gilbertson, B.Med.Sci (Hons), MRCP, PhD
Co-Leader, Neurobiology and Brain Tumor Program; Director, Molecular Clinical Trials Core, Departments of Developmental Neurobiology and Oncology, St Jude Children’s Research Hospital, Memphis, TN, USA
Robert F. Wynn, BA, MD, MRCP, FRCPath
Consultant Paediatric Haematologist and Programme Director, Blood and Marrow Transplant Unit, Royal Manchester Children’s Hospital, Manchester, UK