"As a general gastroenterologists up to half the outpatients I see have functional disease yet I have had no training in the function of the enteric nervous system, and the subject is relatively ignored in gastroenterology meetings. Neurogastroenterology is a difficult subject: it's poorly presented in textbooks, and the medical journals give a very disjointed view. This is the only book that I have read that successfully brings together neurogastroenterology and functional gastroenterological disease in a readable clinically relevant form. It's all the more important because new drugs based on our understanding of neurogastroenterology are becoming available."
Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut - the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome - the most common functional disorder of the bowel.
IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US.
This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.
Table of Contents
Section A - Basic Principals
Chapter 1 Functional Neuro-anatomy
Chapter 2 Neuro-physiology
Chapter 3 Brain to Gut Signalling - Sensory mechanisms
Chapter 4 Brain to Gut Signalling - Central Processing
Section B - Mechanisms of functional GI Disorders
Chapter 5 Developmental disorders of the enteric nervous system
Chapter 6 Inflammation
Chapter 7 Neuroplasticity
Chapter 8 Stress and the Gut - Central Influences
Chapter 9 Stress and the Gut - Peripheral Effects
Section C - Patho-physiology and Treatment of Human Diseases
Chapter 10 Oesophageal disorders
Chapter 11 Gastric disorders
Chapter 12 Small Bowel Disorders
Chapter 13 Colonic disorders
Chapter 14 Anorectal Disorders
Chapter 15 Central Nervous System Injury
Chapter 16 Diarrhoea - Predominant bowel disorders following inflammation and infection
Section D - Advances in Pharmaco Therapy
Chapter 17 Functional targets for pharmaco therapy - An overview
Chapter 18 Neuro Kininin Receptor Modulators
Chapter 19 Serotonin Receptor Modulators
Chapter 20 Emerging Transmitters