Proceedings of the Viiith Conference of the International Society for Trace Element Research Humans Mar/09 Challenges, Prevention, and Interventions

About this book

Current state of knowledge and gaps in experimental evidence related to the physiologic role and toxicity of trace elements in human health were presented and discussed at an international joint conference in Hersonissos, Crete-Greece, in October 2007. The conference (ISTERH/NTES/HTES ‘07) constituted the VIIIth Conference of the International Society for Trace Element Research in Humans (ISTERH), the IXth Conference of the Nordic Trace Element Society (NTES), and the VIth Conference of the Hellenic Trace Element Society (HTES). The focus of the conference is put on the topics:

• Trace minerals as modulators of arterial function
• Zinc nutriture and the fetal origins of disease
• Health consequences of trace element deficiencies
• Copper in neurologic and neurodegenerative diseases
• Health effects of low dose exposure to toxic metals
• Environmental stress and mineral homeostasis
• Molecular mechanisms of metal induced disease
• Advances in analytical detection of trace elements in biological tissues
• Mineral elements and molecular signaling as it relates to human disease
• Is copper involved in carcinogenesis/carcinostatics?
• Zinc and the common cold
• The role micronutrients (iodine, iron and zinc) in intellectual development.

Written for: Academics, biologists, biochemists, toxicologists, ecologists, pharmacologists, epidemiologists, medical researchers, nutritionists, Health and Disease Management, chemists, veterinarians

Table of contents

Preface

Trace elements in human diets, nutrition, and health: essentiality and toxicity

C.D. Hunt

Key Note Address

Mediterranean diet, traditional foods and health: critical components and mediating mechanisms

A. Trichopoulou and E. Vasilopoulou

Plenary Session: Trace Minerals as Modulators of Arterial Function

Manganese: modulator of arterial function and metabolism

D. Klimis-Zacas and A.Z. Kalea

The role of copper in nitric oxide-mediated vasodilation

D.A. Schuschke

Selenium status and regulation of vascular homeostasis

L.M. Sordillo

ISTERH 2007 Raulin Award lecture

Zinc nutriture and the fetal origins of disease

H.H. Sandstead

Plenary Session: Trace element nutrition and dietary recommendations

The relevance of trace element nutrition in human health

S. Ermidou-Pollet and S. Pollet

International dietary standards for trace elements

J. H. Freeland-Graves and J. M. Cahill

Plenary Session: Trace Element Speciation

Salivary arsenic as a biomarker for arsenic exposure

K. Lew, C. Yuan, J.P. Acker and X.C. Le

Plenary Session: Health consequences of trace element deficiencies

Studies on the placental and mammary gland transfer of trace elements: Impact of possible trace

element deficiencies in infancy

E. Rossipal and M. Krachler

An adaptation of the in vitro digestion methodology employed in the prediction of iron bioavailability meets new challenges

K. Argyri, A. Birba, D.D. Miller, M. Komaitis and M. Kapsokefalou

Iodine intake, balance and normative requirement of man in Central Europe

M. Anke, B. Groppel and U. Schäfer

Symposium: Copper in neurologic and neurodegenerative diseases

Overview of the Role of Copper in Neurodegenerative Diseases and Potential Treatment with Tetrathiomolybdate

G.J. Brewer

Copper and cognition in Alzheimer's disease and Parkinson's disease

D.L. Sparks, C. Ziolkowski, D. Connor, T. Beach, C. Adler, M. Sabbagh, J. Caviness, H. Shill, L. Sue, L. Sparks, J. Lopez, S. Johnson-Traver and G. Stankovic

Copper Studies in Alzheimer's Disease Patients

R. Squitti and P.M. Rossigni

Dietary Fat and Copper Effects on Cognition

M.C. Morris

Symposium: Health effects of low dose exposure to toxic metals

Health effects of low dose exposure to toxic metals: introduction and research recommendations

G. Nordberg and S. Skerfving

Proteomic and metabolomic biomarkers for assessing low dose toxic trace element interactions: an overview

B.A. Fowler, E.A. Conner, H. Yamauchi, G. Wang and M.H. Whittaker

Neuropsychological and renal effects of low dose exposure to elemental mercury exposure from amalgam in children

L. Barregard

Manganese exposure as a determinant of Parkinsonian damage

R. Lucchini, R. Squitti, E. Albini, L. Benedetti, S. Borghesi, E. Nan, F. Draicchio, R. Coccaglio and L. Alessio

Kidney and bone effects of low dose cadmium exposure in Sweden

A. Åkesson

Factors influencing dose–response relationships of cadmium in humans—diabetes, metallothionein and metallothionein antibodies

T. Jin, L. Chen, L. Lei, M. Nordberg and G. F. Nordberg

Symposium: Environmental stress and mineral homeostasis

Overview of human physiological responses to environmental extremes

A.J. Young

Iron Homeostasis and Environmental Extremes: Focus on Physical Activity

J.P. McClung

Calcium Metabolism during Space Flight

S.M. Smith and S.R. Zwart

Mineral Losses During Extreme Environmental Conditions

H.C. Lukaski

Symposium: Molecular mechanisms of metal induced disease

Changes in dietary iron levels affect brain manganese accumulation and distribution

V.A. Fitsanakis, Y. Finkelstein and M. Aschner

Reprogramming of histone marks by chromium

A. Puga, Y-D. Wei, A. Maier, L. Peng and M. Schnekenburger

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Symposium: Advances in analytical detection of trace elements in biological tissues

Ion and electron beams methods for biological trace elements characterisation at bioceramics/cells interface

E. Jallot

X-ray fluorescence technique on trace element determination in biological samples

M.L. Carvalho and A. Marques

Symposium: Mineral elements and molecular signaling as it relates to human disease

Role of zinc in endothelial cell function: implications in atherosclerosis

B. Hennig and M. Toborek

Oxidative stress in tumor progression: Intervention by selenium

B. Cat and P. Brenneisen

Influence of zinc on oxidative stress, DNA integrity and cancer risk

E. Ho and Y. Song

Maintaining copper balance: roles of copper transporters and chaperones

J. Bertinato and M.R. L’Abbé

Symposium: Is copper involved in carcinogenesis/carcinostatics?

Possible association of Wilson’s disease with hepatocellular carcinoma

Y-H. Gu, H. Kodama, T. Kato, C. Fujisawa and F. Kaga

Carcinogenesis in LEC rat and patients with Wilson disease

N. Shimizu and T. Aoki

The effects of hepatic copper overload on development of hepatocellular carcinoma in hepatitis C virus -positive patients with chronic liver disease

M. Ebara

Copper transports and carcinostatics: copper transporters regulate the cellular pharmacology of cisplatin

R. Safaei and S.B. Howell

Symposium: Zinc and the common cold

Zinc and the common cold

G.A. Eby

Treatment of the common cold with zinc: effect on pro-inflammatory cytokine (Soluble Interleukin-1 receptor antagonist) and ICAM-1

A.S. Prasad, F.W.J. Beck, B. Bao, D. Snell, and J.T. Fitzgerald

Symposium: The role micronutrients (iodine, iron and zinc) in intellectual development

Essentiality of zinc for human neuropsychological performance

H.H. Sandstead and J.G. Penland

Recent developments on WHO recommendations for the prevention and control of iron, iodine, and zinc deficiencies

L.M. Rogers

Iodine deficiency and intellectual development: the role of The International Council for the Control of Iodine Deficiency Disorders (ICCIDD) in the global push to eliminate iodine deficiency

M.B. Zimmermann