Metastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation.
Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies.
This timely book provides the current knowledge in the area of breast cancer metastasis and will be of important reading material for oncologists, radiologists, cancer researchers, biologists and health workers.
Written for: Cancer Biologists, Biologists, Surgeons, Oncologists, Geneticists, Pathologists, Pharmaceutical and Diagnostics companies in the cancer field, University and cancer centre librariesTable of contents
Chapter-1: Metastasis of breast cancer, an introduction by Robert E. Mansel, Oystein Fodstad and Wen G. Jiang
Chapter-2: The genetic control of breast cancer metastasis by Rajeev S. Samant, Oystein Fodstad and Lalita A. Shevde
Chapter-3: BRCA1 in initiation, invasion and metastasis of breast cancer: a perspective from the tumor microenvironment by Shaun D. McCullough, Yanfen Hu, and Rong Li
Chapter-4: Cell motility and breast cancer metastasis by Marc E. Bracke, Daan De Maeseneer, Veerle Van Marck, Lara Derycke, Barbara Vanhoecke, Olivier De Wever and Herman T. Depypere
Chapter-5: Tight junctions and metastasis of breast cancer by Tracey A. Martin
Chapter-6: Cell adhesion molecules in breast cancer invasion and metastasis by Lalita A. Shevde and Judy A. King
Chapter-7: Endocrine resistance and breast cancer invasion by Stephen Hiscox, Julia Gee and Robert I. Nicholson
Chapter-8: The role of aromatase and other oestrogen producing enzymes in mammary carcinogenesis by Mohemmad Salhab and Kefah Mokbel
Chapter-9: The role of the HGF regulatory factors in breast cancer by Christian Parr and Wen G. Jiang
Chapter-10: The insulin-like growth factor-1 ligand in breast cancer management by Yoon M. Chong, Ash Subramanian and Kefah Mokbel
Chapter-11: Lymphangiogenesis and metastatic spread of breast cancer by Mahir A. Al-Rawi and Wen G Jiang
Chapter-12: Breast cancer secreted factors alter the bone microenvironment by Valerie A. Siclari, Theresa A. Guise, and John M. Chirgwin
Chapter-13: Cyclooxygenease-2 and breast cancer by Gurpreet Singh-Ranger and Kefah Mokbel
Chapter-14: Prognostic and predictive factors in human breast cancer by Pamela N. Munster
Chapter-15: Molecular imaging in metastatic breast cancer by C.P. Schröder, G.A.P. Hospers, P.H.B. Willemse, P.J. Perik, E.F.J. de Vries, P.L. Jager, W.T.A. van der Graaf, M.N. Lub-de Hooge, E.G.E. de Vries
Chapter-16: Detection of disseminated tumor cells in the bone marrow and blood of breast cancer patients by Volkmar Müller and Klaus Pantel
Chapter-17: Sentinel lymph node biopsy in early-stage breast cancer by Amit Goyal and Robert E. Mansel
Chapter-18: Surgical management of patients with metastatic breast cancer, Adam I. Riker, SuHu Liu, Mona Hagmaier, Matthew J. D. D'Alessio, Charles E. Cox
Chapter-19: Therapeutic aspect of metastatic breast cancer, chemotherapy by Robert C.F. Leonard and Thinn P. Pwint
Chapter-20: Hormonal therapies of metastatic breast cancer; the past and the present by Jürgen Geisler and Per Eystein Lønning