Innate and Adaptive Immunity in the Tumor Microenvironment

About this book

Cancer cells continuously interact with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site a tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression.

This volume compiles reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews are from experts in the field who published original research studies focusing on these issues.

Written for:

Basic immunologists, clinical immunologists, oncologists, cell biologists, biochemists, molecular biologists, hematologists

Keywords:

tumor microenvironment, adaptive immunity, innate immunity

Table of contents

Foreword - Tumor Microenvironment under the Magnifying Glass: A New Challenge to Cancer Immunologists
Eitan Yefenof
Chapter 1: Immune Effector Cells in the Tumor Microenvironment: Their Role in Regulation of Tumor Progression
Theresa L. Whiteside
Chapter 2: Histocompatibility Antigens, Tumor Microenvironment and Escape Mechanisms Utilized by Tumor Cells
Soldano Ferrone and Theresa L. Whiteside
Chapter 3: Local Tumor Growth and Spontaneous Systemic T cell Responses in Cancer Patients: a Parodox and Puzzle
Philipp Beckhove and Volker Shirrmacher
Chapter 4: Insights into mechanisms of immune resistance in the tumor microenvironment through molecular profiling
Thomas F. Gajewski
Chapter 5: Tumor Antigens as Modulators of the Tumor Microenvironment
Katja Engelmann and Olivera J. Finn
Chapter 6: Tumor Cell Resistance to Apoptosis by Infiltrating Cytotoxic Lymphocytes
Benjamin Bonavida
Chapter 7: The Tumor Microenvironment as a Model for Tissue-Specific Rejection
Silvia Selleri, Sara Deola, Cristiano Rumio and Francesco M. Marincola
Chapter 8: Functional Cytotoxicity of T Cells at the Tumor Environment
Michal Lotem, Arthur Machlenkin, Shoshana Frankenburg and Tamar Peretz
Chapter 9: Natural Killer Cells at the Tumors Microenvironment
Roi Gazit and Ofer Mandelboim
Chapter 10: Contribution of the Microenvironment to the Pathogenesis of EBV-positive Hodgkin and NK/T-cell Lymphomas
Eva Klein, M. Takahara and LL Kis