Programmed Cell Death in Cancer Progression and Therapy (Advances in Experimental Medicine and Biology, Vol. 615)

About this book

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has dramatically risen. This book offers a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, it will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeutics.

Written for:

Academic and industrial researchers investigating the role of PCD in cancer and other diseases (postdoctoral fellows, Ph.D. students and technicians), researchers investigating the molecular mechanism of chemotherapeutic agents, researchers investigating drug-resistance in cancer, physicians using chemotherapeutic agents (majority of which induce apoptosis), PhD students specializing in cell biology, immunology, MD students interested in Oncology and Cancer Therapeutics, Libraries at Major Universities, Medical Schools, Biomedical Research Institutes, Biomedical Research Foundations, Research Hospitals and Pharmaceutical companies

Keywords:

Cell death, apoptosis, cancer research,Khosravi-Far

Table of contents

Introduction
Chapter 1: Cell Death: History and Future by Zahra Zakeri and Richard A. Lockshin
Chapter 2: Caspase Mechanisms by Guy S. Salvesen and Stefan J. Riedl
Chapter 3: The Mitochondrial Death Pathway by Anas Chalah and Roya Khosravi-Far
Chapter 4: Apoptotic Pathways in Tumor Progression and Therapy by Armelle Melet, Keli Song, Octavian Bucur , Zainab Jagani, Alexandra R. Grassian and Roya Khosravi-Far
Chapter 5: Therapeutic Targeting of Death Pathways in Cancer - Mechanisms for activating cell death in cancer cells by Ting-Ting Tan and Eileen White
Chapter 6: Overcoming Resistance to Apoptosis in Cancer Therapy by Peter Hersey, X.D. Zhang, N. Mhaidat
Chapter 7: TRAIL Receptors: Targets for Cancer Therapy by Robin C. Humphreys and Wendy Halpern
Chapter 8: Rational Design of Therapeutics Targeting the Bcl-2 Family - Are some cancer cells primed for death but waiting for a final push? by Victoria Del Gaizo Moore and Anthony Letai
Chapter 9: Autophagy and Tumor Suppression - Recent advances in understanding the link between autophagic cell death pathways and tumor development by Shani Bialik and Adi Kimchi
Chapter 10: Regulation of Programmed Cell Death by the p53 Pathway by Kageaki Kuribayashi and Wafik S. El-Deiry
Chapter 11: Regulation Of Programmed Cell Death by Nf-k B and its Role in Tumorigenesis and Therapy by Yongjun Fan, Jui Dutta, Nupur Gupta, Gaofeng Fan and Céline Gélinas
Chapter 12: Targeting Proteasomes as Therapy in Multiple Myeloma by Dharminder Chauhan, Teru Hideshima and Kenneth C. Anderson
Chapter 13: Histone Deacetylase Inhibitors: Mechanisms and Clinical Significance in Cancer - HDAC inhibitor-induced apoptosis by Sharmila Shankar and Rakesh K. Srivastava
Chapter 14: RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches by Derek M. Dykxhoorn, Dipanjan Chowdhury, Judy Lieberman
Chapter 15: Cancer Stem Cells and Impaired Apoptosis by Zainab Jagani and Roya Khosravi-Far