Stem Cells and Their Potential for Clinical Application

About this book

The NATO-ASI conference Stem Cells and Their Potential for Clinical Application, held in Kiev and Simeiz (Ukraine) in August 2006, featured cutting-edge presentations ranging from laboratory research findings to the latest therapeutic applications. This book features contributions from many of the leading international scientists who participated in this conference.

Articles cover a broad range of hot topics in stem cell and leukemia research. These include the potential of various stem cell types in regenerative and transplantation medicine and different mechanisms of malignant transformation leading to leukemia development. The book also presents novel clinical strategies for malignant disease treatment, such as adoptive immunotherapy with gene-modified lymphocytes.

The mixture of articles written by principal scientists from North America as well as Eastern and Western Europe provides an overview of major developments as well as interesting perspectives on distinct approaches to stem cell research, immunotherapy, and gene therapy.

Written for:

Scientists in Biomedicine, researchers engaged in stem cell, cancer & leukaemia research and/or cell biology, clinical and research haematologists, physicians and scientists in the field of haematopoietic stem cell transplantation, physicians active in regenerative and transplantation medicine, scientists and physicians interested in immunotherapy

Table of contents

I. HAEMATOPOIETIC STEM CELLS AND HAEMATOPOIESIS. Clonal Dominance After Reconstitution of the Haematopoietic System with Bone Marrow Cells
Retrovirally Transduced with Murine CD34 Variants; G.von Keudell et al.- Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Self-Renewal of Early Hematopoietic Progenitor Cells; J. Friel et al.- Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cells (HSC) Compartment; O.I. Gan et al.- Alterations of Frequency of Hematopoietic Precursors in Mice Subjected to Multiple Courses of Low-Dose G-CDF Injections; I.N. Nifontova et al.- Regulation of Hematopoiesis by Growth Factors; E.R. Stanley.-

II. BIOLOGY OF NON-HAEMATOPOIETIC STEM CELLS. Stem Cell Technologies in Gerontological Research; G.M. Butenko.- Osteopetrotic Models for Identifying Genes that Control Bone Resorption; W.Wiktor-Jedrzejczak.- Non-Hematopoietic Bone Marrow Cells for Regenerative Medicine; C. Lange et al.- Epithelial Plasticity of Hepatocytes during Liver Tumor Progression; M. Mikula et al.- Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life; M. Crisan.-

III. STEM CELLS AND MALIGNANCY. Stem Cells and Leukemia; V. Bebeshko et al.- Telomere and Stem Cell Biology in Chronic Myeloid Leukemia; S. Balabanov et al.- Potential Immune Escape Mechanisms of Tumors: MHC Class I Molecules – Enemies or Friends; B. Seliger.-The RUNXI Transcription Factor: A Gatekeeper in Acute Leukemia; C. Stocking et al.-

IV. CELL PROCESSING, EXPANSION AND GENETIC MODIFICATION. Novel Methodological Approaches in Assessment and Enrichment of Stem Cell Population; N.M. Bilko et al.- Animal Hybrids and Stem Cells Their Use in Biotechnology and Clinical Practice; L.P. Djakonov.- Cryopreservation of Stem Cells; V.I. Grischenko et al.- The M813 Retrovirus Belongs to a Unique Interference Group and is highly Fusogenic; V. Prassolov.- Reconstructing an Anti-Tumor Immune Repertoire for Targeted AML Therapy; M. Theobald.-

V. CLINICAL HAEMATOPOIETIC STEM CELL TRANSPLANTATION. Experience of Kyiv Center of Stem Cell Transplantation; V.I. Khomenko.- Anti Thymocyte Globuline Allows for Successful Transplantation from HLA Mismatched Unrelated Donors; A.R. Zander et al.