Frontiers in Research of the Renin-Angiotensin System on Human Disease (Proteases in Biology and Disease 7)

Description

• A topical, timely and focused book in this field
• A collection of succinct and comprehensive book chapters from experts globally
• A close link between basic and clinical research on the renin-angiotensin system
• An indispensable tool tailor-made for specialists, non-specialists and the novice

The significant impact of the renin-angiotensin system (RAS) on basic research and its clinical relevance are reflected in a number of ways; by the flourishing publication of original and review research articles, by the appearance of whole issues of journals dedicated to the RAS, and by specialist books on the RAS. In such a rapidly evolving environment, publications that span the spectrum from basic research to the bedside, fill a valuable niche for clinicians and researchers alike.

The primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of RAS research that is expanding rapidly. In this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the RAS and their implications in human disease. It is clear that outstanding work on the novel roles of local RAS and their potential clinical application is being done in laboratories and clinics across the globe.

Table of Contents

1. Role of ACE, ACE2 and Neprilysin in the kidney, Mark C. Chappell;
2. ACE Inhibition in Heart Failure and Ischaemic Heart Disease, D. John Campbell;
3. Proteases of the Renin-Angiotensin System in Human Acute Pancreatitis, R. Pezzilli and L. Fantini;
4. The Renin-Angiotensin System in Pancreatic Stellate Cells: Implications in the Development and Progression of Type 2 Diabetes Mellitus, Seung-Hyun Ko, Yu-Bai Ahn, Ki-Ho Song and Kun-Ho Yoon;
5. Renin-Angiotensin System Proteases and the Cardiometabolic Syndrome: Pathopjysiological, Clinical and Therapeutic Implications, Guido Lastra, Camila Manrique and James R. Sowers;
6. The Role of the Renin-Angiotensin System in Hepatic Fibrosis, J.S. Lubel, F.J. Warner and P.W. Angus;
7. The Renin-Angiotensin System in the Breast, Gavin P. Vinson, Stewart Barker, John R. Puddefoot and Massoumeh Tahmasebi;
8. Role of Local Renin-Angiotensin System in the Carotid Body and in Diseases, Man Lung Fung and Po Sing Leung;
9. Bone Homeostasis: An Emerging Role for the Renin-Angiotensin System, C. Serina, H. Huang, K. Nguyen, L. Li, S. Hsu, M. Chen, N. Yu and M. Forwood;
10. The Renin-Angiotensin System and its Inhibitors in Human Cancers, Lucienne Juillerat-Jeanneret;
11. The Skeletal Muscle RAS in Health and Disease, David R. Woods;
12. Local Angiotensin Generation and AT2 Receptor Activation, Joep H.M. van Esch and A.H. Jan Danser;
13. ADAMs as Mediators of Angiotensin II Actions, A.M. Bourne and W. G. Thomas;