This book has arisen from a NATO-sponsored international meeting on problems of high altitude medicine and biology, which was held on the shores of lake Issyk-Kul, in Kyrghyzstan, in June 2006.
The meeting considered a mix of cell biology, integrative physiology and medical applications. The classic high-altitude condition of hypoxia remains a major public health issue in many populated mountainous areas all over the world and is discussed in detail.
The meeting was remarkable in several ways. The participants enjoyed the beauty of the blue waters of this 1610 m high sacred lake, with stunning views towards the Tien Shan mountain range at a distance, and, most of all, the wonderful Kyrghyz hospitality and friendship.
It was a surprise for several European and North and South-American scientists to discover the still on-going momentum in high level altitude physiology research, which was extremely active but insufficiently acknowledged in this remote Central Asian country at the time of the USSR.
Accordingly, the setting was perfect for numerous positive scientific interactions, exchanges of ideas, and structuring of new international collaborations.
This book will be become a long-lasting essential reference.
Fundamental scientists interested in the effects of hypoxia, medical doctors in charge of high altitude related problems
- Sub-Series A
Table of contents
- 1. 45 Years of mountain medicine; J.S. Milledge.-
- 2. High altitude pulmonary hypertension and chronic mountain sickness; D. Penaloza.-
- 3. The Cellular effects of hypoxia on the pulmonary circulation; A. Peacock et al.-
- 4. Angiogenesis and chronic hypoxic pulmonary hypertension; S. Eddahibi et al.-
- 5. Tetrahydrobiopterin and pulmonary hypertension; L. Zhao et al.-
- 6. Hypoxia-induced proliferation of human pulmonary arterial smooth muscle cell is involved in the suppression of cyclin-dependent kinase inhibitors; T. Ishizaki et al.-
- 7. Pulmonary adaptation to high altitude in wild mammals; S. Akio et al.-
- 8. Lung at high altitude: between physiology and pathology; A. Cogo et al.-
- 9. Sildenafil and hypoxic pulmonary hypertension; B. Kojonazarov et al.-
- 10. The role of antioxidants in modulation of acclimatization processes; A.Z. Zurdinov.-
- 11. Gene polymorphisms and high altitude pulmonary hypertension; A.A. Aldashev.-
- 12. Genetic factors in the acute response to hypoxia in animals models; K.P. Strohl.-
- 13. Who gets high altitude pulmonary edema and why?; P. Bärtsch et al.-
- 14. Effects of inhaled nitric oxide and oxygen in high altitude pulmonary edema; I.S. Anand.-
- 15. Altered autoregulation of cerebral blood flow in hypoxia. Relevance to the pathophysiology of acute mountain sickness; R. Naeije, A. van Osta.-
- 16. Cardiac limitation to exercise capacity at high altitudes; S. Huez et al.-
- 17. Pediatric high altitude heart disease: a hypoxic pulmonary hypertension syndrome; Tian-Yi Wu.-
- 18. Clinical and functional features of COPD at the highlanders of Kyrgyzstan; T.M. Sooronbaev et al.-
- 19. Monitoring of morphological and functional parameters of platelets at patients with thrombocytopenic purpura during high mountains treatment; A.R. Raimjanov et al.-
- 20. Role of exogenous hypoxia in treatment of chronic Glomerulonephritis; R.R. Kaliev, M.M. Mirrakhimov.-
- 21. Atherogenesis of brain vessels in conditions of hypoxia at Kyrgyz highlanders; T.K. Kadyraliev.-
- 22. Particularities of Neuropsychotropic Effects of Mexidol in Conditions of Various Altitude; U.M. Tilekeeva et al.-
- 23. Influence of high-altitude hypoxia on adaptive and dysadaptive structural changes in the vessels of the pulmonary circulation vessels; T.K. Kadyraliev et al.
- 24. Acute Oxygen Sensing Mechanisms; E.K. Weir.-