HOFFBRAND's Essential Haematology

Preface to the Ninth Edition

About the Companion Website 

1 Haemopoiesis 1

2 Erythropoiesis and general aspects of anaemia 11

3 Hypochromic anaemias 27

4 Iron overload 42

5 Megaloblastic anaemias and other macrocytic anaemias 50

6 Haemolytic anaemias 65

7 Genetic disorders of haemoglobin 79

8 The white cells, part 1: granulocytes, monocytes and their benign disorders 99

9 The white cells, part 2: lymphocytes and their benign disorders 116

10 The spleen 131

11 The aetiology and genetics of haematological neoplasia 138

12 Management of haematological malignancy 155

13 Acute myeloid leukaemia 168

14 Chronic myeloid leukaemia 185

15 Myeloproliferative neoplasms 194

16 Myelodysplastic neoplasms 210

17 Acute lymphoblastic leukaemia 222

18 The chronic lymphocytic leukaemias 236

19 Hodgkin lymphoma 246

20 Non-Hodgkin lymphomas 1: General aspects 259

21 Non-Hodgkin lymphomas 2: Individual diseases 270

22 Multiple myeloma and related plasma cell neoplasms 287

23 Amyloid 302

24 Aplastic anaemia and bone marrow failure syndromes 309

25 Haemopoietic stem cell transplantation 320

26 Platelets, coagulation and normal haemostasis 337

27 Bleeding disorders caused by platelet and vascular abnormalities 355

28 Hereditary coagulation disorders 370

29 Acquired coagulation disorders and thrombotic microangiopathies 385

30 Thrombosis 1: Pathogenesis and diagnosis 399

31 Thrombosis 2: Treatment 417

32 Haematological changes in systemic diseases 437

33 Blood transfusion 451

34 Pregnancy and neonatal haematology 465

Appendix: 5th edition (2022) of the World Health Organization Classification of Haematolymphoid Tumours 475

Index 478

Now in its ninth edition, Hoffbrand's Essential Haematology remains the definitive introductory textbook in the field. A team of leading experts provide clear and authoritative coverage of fundamental areas of clinical and laboratory haematology, including basic science, clinical features, diagnostic procedures and patient management. The text includes hundreds of high-quality colour images illustrating different anaemias, white cell and platelet disorders, leukaemias, myeloproliferative diseases, lymphomas, myeloma, bleeding and thrombotic disorders.

Thoroughly revised and updated, Hoffbrand's Essential Haematology reflects current knowledge of the pathogenesis of blood diseases, their classification, diagnosis and treatment algorithms incorporating novel agents. The role of detection of minimal residual disease in management, and recent advances in immunological treatment of benign and malignant blood disorders, including CAR-T cell therapy, are highlighted. This edition contains expanded coverage of clonal haemopoiesis, the non-Hodgkin lymphomas amyloidosis, hospital related thrombosis, new treatments for haemophilia, and the use of direct-acting oral anticoagulants. Gene therapy for sickle cell anaemia, thalassaemia, and haemophilia feature and a new section focuses on the haematological consequences of COVID-19 infection and vaccine-induced immune thrombotic thrombocytopenia (VITT).

Helping medical students and trainee doctors understand the core principles of clinical and laboratory haematology for more than 40 years, Hoffbrand's Essential Haematology:

• Describes the formation and function of blood cells and the diseases that arise from the bone marrow, lymph nodes and blood
• Provides comprehensive and up-to-date coverage of molecular and immunological basis, diagnosis, and management of blood diseases
• Covers a wide range of key topics, including stem cell transplantation, blood transfusion, the haematological aspects of systemic diseases, of pregnancy and of the neonate
• Incorporates the current 5th World Health Organisation (WHO) classification of haematological neoplastic diseases
• Includes access to a companion website with hundreds of multiple-choice questions, PowerPoint slides, and other teaching and learning resources

Hoffbrand's Essential Haematology, Ninth Edition, is a must-have resource for undergraduate medical students, biomedical science undergraduates and postgraduates, and trainees in haematology.

A. Victor Hoffbrand, Emeritus Professor of Haematology, University College , London, UK

Contributing Authors

Pratima Chowdary, Professor of Haemophilia and Haemostasis, University College. London, UK

Graham Collins, Associate Professor of Haematology and Lymphoma Specialist, Oxford Cancer and Haematology Center, Oxford, UK.

Justin Loke, AACR-CRUK Transatlantic Fellow, Dana-Farber Cancer Institute, Boston, USA and University of Birmingham, UK