Gene Regulation and Therapeutics for Cancer

Programmed Death 1 Receptor (PD-1)-mediated Immunomodulatory Effects in Pancreatic Cancer

Ashu Shah, Catherine Orzechowski and Maneesh Jain

Nuclear Factor Kappa-B: Bridging Inflammation and Cancer

Mohammad Aslam Khan, Girijesh Kumar Patel, Haseeb Zubair, Nikhil Tyagi, Shafquat Azim, Seema Singh, Aamir Ahmad and Ajay Pratap Singh

The S100A7/8/9 Proteins: Novel Biomarker and Therapeutic Targets for Solid Tumor Stroma

Sanjay Mishra, Dinesh Ahirwar, Mohd W. Nasser and Ramesh K. Ganju

Nuclear Receptor Coactivators: Mechanism and Therapeutic Targeting In Cancer

Andrew Cannon, Christopher Thomson, Rakesh Bhatia and Sushil Kumar

Liquid Biopsies for Pancreatic Cancer: A Step Towards Early Detection

Joseph Carmicheal, Rahat Jahan, Koelina Ganguly, Ashu Shah and Sukhwinder Kaur

Targeting Subgroup-specific Cancer Epitopes for Effective Treatment of Pediatric Medulloblastoma

Sidharth Mahapatra and Naveen Kumar Perumal

Aberrant Methylation of UC Promoters in Human Pancreatic Ductal Carcinomas

Michiyo Higashi and Seiya Yokoyama

Receptor Tyrosine Kinase Signaling Pathways as a Goldmine for Targeted Therapy in Head and Neck Cancers

Muzafar A. Macha, Satyanarayana Rachagani, Sanjib Chaudhary, Zafar Sayed, Dwight T. Jones and Surinder K. Batra

Molecular Drivers in Lung Adenocarcinoma: Therapeutic Implications

Imayavaramban Lakshmanan and Apar Kishor Ganti

Molecular Mediator of Prostate Cancer Progression and Its Implication in Therapy

Samikshan Dutta, Navatha Shree Sharma, Ridwan Islam and Kaustubh Datta

Therapeutic Options for Prostate Cancer: A Contemporary Update

Sakthivel Muniyan, Jawed A. Siddiqui and Surinder K. Batra

Regulation and Targeting of MUCINS in Pancreatic Cancer

Shailendra K. Gautam, Grish C. Varshney and Parthasarathy Seshacharyulu

Targeted Therapy for Cancer Stem Cells

Rama Krishna Nimmakayala, Saswati Karmakar, Garima Kaushik, Sanchita Rauth, Srikanth Barkeer and Moorthy P. Ponnusamy

Advances in biotechnology have brought gene therapy to the forefront of medical research. The prelude to successful gene therapy, i.e. the efficient transfer and expression of a variety of human genes into target cells, has already been accomplished in several systems. Specifically, gene regulation and targeted therapy are essential for cancer and thus gene regulation and therapeutics are a practical addition to the arsenal of approaches to many human therapies in the 21st century. This book focuses on specific gene regulation and therapeutics in various cancers and new technology used in the field, giving an overall picture to scientists and physicians who are working in cancer research.

Surinder K. Batra, department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

Moorthy Palanimuthu Ponnusamy Ph.D, department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.