Nutrition and Diabetes. Pathophysiology and Management

Section I PATHOPHYSIOLOGY AND TREATMENT OF OBESITY

Chapter 1

Central and Peripheral Modulators of Appetite and Satiety

Gabrielle Page-Wilson, Sam Dagogo-Jack

Chapter 2

Genetic Determinants of Nutrient Processing

Nicholette Allred

Chapter 3

The Enteroinsular Axis - Contribution to Obesity-Diabetes and its Treatments

Varun Pathak, Nigel Irwin, Peter Flatt

Chapter 4

Metabolic Syndrome: Recognition, Etiology and Physical Fitness as a Component

Robert McGarrah III and William E. Kraus

Chapter 5

Fat Distribution and Diabetes

Michael D Jensen

Chapter 6

Combined Effect of Diet and Physical Activity in the Management of Obesity

Gary Miller

Chapter 7

Pharmacological Treatment of Obesity

Ayotunde Dokun

Chapter 8

Role of Gut Microbiota in the Pathogenesis and Treatment of Obesity

Stephen J Walker and Puja B Patel

Chapter 9

Bariatric Surgery for Obesity

Adolfo Fernandez

Chapter 10

Postoperative Management of the Bariatric-Surgery Patient

Gary Miller

Section II PATHOPHYSIOLOGY AND TREATMENT OF DIABETES

Chapter 11

Economic Burden of Diabetes and Its Complications

William F. Kendall, Jr.

Chapter 12

Nutrient Interactions and Glucose Homeostasis

Emmanuel C. Opara

Chapter 13

Pathophysiology and Approach to Management of Type 2 Diabetes

Wanda Lakey & Mark N. Feinglos

Chapter 14

Type 2 Diabetes in Childhood: Diagnosis, Pathogenesis, Prevention, and Treatment

Robert Benjamin and Michael Freemark

Chapter 15

The contribution of iron and transition metal micronutrients to diabetes and metabolic disease

Donald A McClain

Chapter 16

Role of Microbiota in the Pathogenesis and Treatment of Diabetes

Stephen J Walker Shaun P Deveshwar

Chapter 17

Achieving a Healthy Body Weight in Later Life: Interventions to Reduce Type 2 Diabetes Risk

Connie W. Bales

Chapter 18

Primary Prevention of Type 2 Diabetes: From Research to Community

Natascha Thompson, MD, Sam Dagogo-Jack

Chapter 19

Management of Diabetes Mellitus in Sub-Saharan Africa: Focus on Nigeria

Olufemi Fasanmade

Chapter 20

Diabetes in Pregnancy

Jacques Samson

Chapter 21

Pathophysiology and Management of Type 1 Diabetes: Rational Design of Insulin Therapy

Steven Edelman

Chapter 22

Automated Detection of Meals from Glucose Measurements for use in Artificial Pancreas Systems

Ali Cinar

Chapter 23

Oxidative Stress and the effects of Dietary Supplements on Glycemic Control in Type 2 Diabetes

Emmanuel C. Opara

Chapter 24

Management of Diabetic Gastroparesis

Kenneth Koch & Khalil Bitar

Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor, Nutrition and Diabetes: Pathophysiology and Management, Second Edition, is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches.

Features

• Highlights the role of nutrition in the pathogenesis of obesity and diabetes
• Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of Diabetes
• Features emerging therapeutic approaches for management of obesity and diabetes
• Discusses experience in the management of obesity and diabetes in developing countries
• Presents challenges in insulin therapy and provides guidelines to overcome them

The first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition, new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes.

Emmanuel C. Opara, PhD, received his M.Sc degree in Clinical Biochemistry at the University of Surrey in England and a Ph.D. in Medical Biochemistry from the University of London. After a WHO-sponsored research fellowship in Endocrinology/Metabolism at the Mayo Clinic in Rochester, MN he was a visiting fellow at the NIDDK, NIH in Bethesda, MD before spending 15 years on faculty at the Duke University Medical Center in Durham, NC. He subsequently was a research professor in the Biomedical Engineering program at the Illinois Institute of Technology, Chicago while serving as a senior investigator in the Human Islet Transplant program at the University of Chicago. He accepted his present position as a professor at the Wake Forest Institute for Regenerative Medicine (WFIRM) in 2009 and currently serves as a professor in the Center on Obesity, Diabetes & Metabolism at the Wake Forest School of Medicine. He also serves as professor and graduate program director at the Wake Forest University campus in Winston-Salem, NC of the joint Virginia Tech-Wake Forest School of Biomedical Engineering & Sciences (SBES). Dr. Opara is a member of many professional organizations including the American Diabetes Association, American Federation for Medical Research, and the American Pancreatic Association. He was honored by the Society of Black Academic Surgeons with a distinguished service award in 2007.

Sam Dagogo-Jack, MD is Professor of Medicine and Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Tennessee Health Science Center, Memphis, TN, where he holds the A. C. Mullins Endowed Professorial Chair in Translational Research and also serves as Director of the General Clinical Research Center at UTHSC. Dr. Dagogo-Jack’s current research focuses on the interaction of genetic and environmental factors in the prediction and prevention of prediabetes and diabetes. He is a Principal Investigator of the Diabetes Prevention Program Outcomes Study (DPPOS), the Epidemiology of Diabetes Interventions and Complications (EDIC) study, and the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study, all funded by the National Institutes of Health. A recipient of the Distinction in Endocrinology Award from the American College of Endocrinology, Dr. Dagogo-Jack treats patients with diabetes, endocrine, and metabolic disorders and also directs the Endocrinology Fellowship Training Program at UTHSC.