The Physiological Basis of Metabolic Bone Disease

Description

Research into metabolic bone disease has made remarkable progress over the last 20 years, with the identification of numerous new molecules and pathways regulating bone cells as well as their plasma milieu. Their activities are largely regulated by the physiologicalstatus of the body incorporating the biochemical, physical and mechanical functions of bone, kidney and intestinal tissues. ThePhysiological Basis of Metabolic Bone Disease integrates the knowledge derived from molecular techniques with the fundamental principles of the physiology of these organs.

The book places particular emphasis on bone cell activities and the regulation of plasma calcium, phosphate homeostasis, and whole body nutrition. It reviews the nutritional requirements for calcium and vitamin D for the prevention of osteoporosis. It covers vitamin D, calcium and phosphate absorption; calcium sensing receptors; the role of parathyroid hormone; physiological actions of calcitonin; and the diagnosis and significance of osteoporosis. Reviewing the physiological significance of advances in the molecular biology of metabolic bone disease, this book provides a valuable reference for researchers as well as practicing clinicians.

Features

• Provides a comprehensive overview of calcium, phosphate, and bone tissue physiology
• Describes the pathophysiology of metabolic bone disease
• Presents molecular and physiological aspects of calcium and phosphate homeostasis, calciotrophic hormones, and bone mineralization
• Demonstrates the physiology of mineral homeostasis with clinical implications for mineral disorders
• Recognizes nutrition as an environmental factor in mineral homeostasis

Contents

Nutritional Requirements for Calcium and Vitamin D
J. Christopher Gallagher

Physiology of Vitamin D, Calcium, and Phosphate Absorption
James C. Fleet and Munro Peacock

Plasma and Extracellular Fluid Calcium Homeostasis in Relation to Metabolic Bone Disease: Role of Kidneys
Richard L. Prince

Calcium Sensing Receptors: Coordinators of Mineral Metabolism and Therapeutic Targets for Metabolic Bone Disorders
Arthur D. Conigrave

Parathyroid Hormone: Its Role in Calcium and Phosphate Homeostasis
David Goltzman

Phosphate Homeostasis and Metabolic Bone Disease
Farzana Perwad and Anthony A. Portale

Vitamin D: Activities for Bone Health
Howard A. Morris, Paul H. Anderson, and B.E. Christopher Nordin

Physiological Actions of Calcitonin
Rachel A. Davey and David M. Findlay

Definition, Diagnosis, and Significance of Osteoporosis
B.E. Christopher Nordin and Richard L. Prince