Preface vii
List of Contributors ix
Foreword xiii
Abbreviations xvii
Section I: Background 1
1 A Brief History of Particle Radiotherapy 3
2 The Physics of Particle Therapy 11
3 The Radiobiology of Particle Therapy 27
4 Practical Aspects of Particle Therapy Accelerators 47
5 Treatment Planning for Scanning Beam Proton Therapy 55
6 Image-Guided Particle Therapy and Motion Management 81
7 Advanced Particle Therapy Delivery: A Review of Advanced Techniques for Particle Therapy Delivery 101
8 FLASH Radiotherapy 115
9 Boron Neutron Capture Therapy 121
10 Grid Therapy 137
11 Particle Therapy and the Immune System 151
12 The Economics of Particle Therapy 165
Section II: Particle Therapy by Clinical Indication 177
13 Intracranial Tumors: Principles and Practice of Particle Therapy 179
14 Ocular Malignancies 201
15 Brain, Skull Base, and Spinal Tumors 225
16 Head and Neck Cancers 239
17 Thoracic Malignancies: Proton Beam and Carbon-ion Therapy for Thoracic Cancers and Recurrent Disease 261
18 Gastrointestinal Tumors 287
19 Hepatobiliary Cancers 311
20 Breast Cancer 357
21 Prostate Cancer 383
22 Non-prostate Genitourinary Cancers 411
23 Gynecologic Cancers 425
24 Lymphoma and Leukemia 445
25 Sarcomas and Soft Tissue Malignancies 465
26 Pediatric Central Nervous System Tumors 483
27 Particle Therapy for Non-CNS Pediatric Malignancies 495
Index 521
