Clinical Pancreatology for Practicing Gastroenterologists and Surgeons

Contributors

Foreword

Preface

Dedication

1 Acute pancreatitis: An overview

Jodie A. Barkin, Jamie S. Barkin

2 How to deal with the etiological diagnosis of acute pancreatitis in clinical practice

Soumya Jagannath, Pramod Kumar Garg

3 Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice

David X. Jin, Peter A. Banks, Julia McNabb-Baltar

4 Early prediction of severity in acute pancreatitis: What can be done in clinical practice?

Peter J Lee, Georgios I Papachristou

5 Role of CT Scan in Acute Pancreatitis: When is it Indicated and What Information can be Obtained?

Elham Afghani, Mahya Faghih, Vikesh Singh

6 Role of MRI in acute pancreatitis. When is it indicated and what information can be obtained?

Fatih Akisik

7 Treatment of acute pancreatitis in the emergency room: What should be done during the first hours of disease?

Thiruvengadam Muniraj and Santhi Swaroop Vege

8 Acute pancreatitis: A practical guideline for the monitoring and treatment of systemic complications

Enrique de-Madaria and Felix Zubia-Olaskoaga

9 Guidelines for the treatment of pain in acute pancreatitis

László Czakó

10 Nutrition in the acute phase of pancreatitis: Why, when, how and how long?

Angela Pham and Chris E Forsmark

11 Oral refeeding in acute pancreatitis: When and how should it be restarted?

José Lariño-Noia, Daniel de la Iglesia-García

12 Pharmacological therapy for acute pancreatitis: any light at the end of the tunnel?

Rajarshi Mukherjee, Muhammad Awais, Wenhao Cai, Wei Huang, Peter Szatmary, Robert Sutton

13 Indication and optimal timing of ERCP in acute pancreatitis

Theodor Voiosu, Ivo Boškoski, Guido Costamagna

14 How to deal with infected pancreatic necrosis?

J. Enrique Domínguez Muñoz

15. Minimally invasive surgical necrosectomy in clinical practice: Indications, technical issues and optimal timing.

Patricia Sánchez-Velázquez, Fernando Burdío, Ignasi Poves

16 Endoscopic Necrosectomy in Clinical Practice: Indications, Technical issues and Optimal Timing

Jodie A Barkin, and Andres Gelrud

17 MANAGEMENT OF ACUTE PANCREATIC PSEUDOCYST: WHEN TO OBSERVE, WHEN AND HOW TO DRAIN

Muhammad F. Dawwas, Kofi W. Oppong

18 The disconnected main pancreatic duct syndrome: How to proceed with it in clinical practice?

Mario Peláez-Luna, Andrea Soriano-Ríos, Luis Uscanga-Dominguez

19 Vasculature Complications in Pancreatitis: How to Deal with Them?

Daniel G. McCall and Timothy B. Gardner

20 Acute relapsing pancreatitis: What can be done to prevent relapses?

Jorge D. Machicado, Dhiraj Yadav

21 Diagnosis and therapeutic approach to pancreatic exocrine insufficiency after acute pancreatitis

H.C. Timmerhuis, C. J. Sperna Weiland, H.C. van Santvoort

22 Asymptomatic chronic elevation of serum pancreatic enzymes: How to deal with it?

Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso

23 Definition and etiology of chronic pancreatitis: What is relevant for clinical practice?

David C. Whitcomb

24 Epidemiology of chronic pancreatitis: An infrequent disease or an infrequently diagnosed disease?

Philippe Lévy, Vinciane Rebours

25 Alcoholic chronic pancreatitis and the impact of alcohol and smoking cessation in chronic pancreatitis

JS Wilson, RC Pirola, MV Apte

26 What is relevant on genetics in chronic pancreatitis for clinical practice? What genes and when to evaluate them?

Jonas Rosendahl

27 Pancreas divisum and other potential obstructive causes of chronic pancreatitis (When and how to treat them?)

Matthew J. DiMagno, Erik-Jan Wamsteker

28 What to do in clinical practice before defining a chronic pancreatitis as idiopathic? A practical protocol

Felix Lämmerhirt, Frank Ulrich Weiss, Markus M. Lerch

29 CT for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice

Roberto García-Figueiras, Sandra Baleato-González, Gonzalo Tardáguila de la Fuente

30 Role of MRI and MRCP for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice.

Jordan K. Swensson, Temel Tirkes

31 Role of endoscopic ultrasound and associated methods (elastography, contrast enhancement) for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice.

Julio Iglesias-Garcia

32 Endoscopic pancreatic function test for the functional diagnosis of chronic pancreatitis: indications and practical protocol

Luis F. Lara, Darwin L. Conwell

33 Role of pancreatic function tests for the diagnosis of chronic pancreatitis: Which tests and how should they be performed in clinical practice?

J. Enrique Domínguez Muñoz

34 Follow-up of patients with chronic pancreatitis in clinical practice: How and what for?

Antonio Mendoza Ladd, Luis F. Lara, Darwin L. Conwell

35 QUALITY OF LIFE IN CHRONIC PANCREATITIS

Colin D Johnson

36 Medical treatment of pain in chronic pancreatitis:  Guidelines for clinical practice

Asbjørn Mohr Drewes, Louise Kuhlman, Trine Andresen & Søren Schou Olesen

37 Endoscopic treatment of pain in chronic pancreatitis:

Indications, optimal timing and technical aspects

P.M.C. Stassen, P.J.F. de Jonge, J.W. Poley, D.L. Cahen, M.J. Bruno

38  Diagnosis and management of pancreatic exocrine insufficiency in chronic pancreatitis: A practical protocol

J. Enrique Domínguez-Muñoz

39 Surgical treatment of pain in chronic pancreatitis: indications, optimal timing and technical approaches

 Benjamin PT Loveday, John A Windsor

40 Management of chronic pancreatic pseudocyst: when to observe, when and how to drain?

Shyam Varadarajulu

41 Vascular complications in chronic pancreatitis

Anil K Agarwal, Raja Kalayarasan, Amit Javed

42 SURGICAL THERAPY OF LOCAL COMPLICATIONS OF CHRONIC PANCREATITIS: INDICATIONS, TECHNICAL APPROACHES AND OPTIMAL TIMING

Ricardo Arvizu Castillo, Elena Muñoz-Forner, Luis Sabater

43 Endoscopic treatment of complications of chronic pancreatitis other than pseudocyst

Jahangeer Basha, Rupjyoti Talukdar, D. Nageshwar Reddy.

44 Autoimmune pancreatitis: Definition, clinical presentation and classification.

Miroslav Vujasinovic and J.-Matthias Löhr

45 Diagnosis of Autoimmune Pancreatitis: a Protocol for Clinical Practice

Nicolò de Pretis , Antonio Amodio and Luca Frulloni

46 Treatment and follow-up of autoimmune pancreatitis in clinical practice

Sushil Kumar Garg, Suresh T Chari

47 CFTR-associated pancreatic disease: genotype-phenotype correlations and impact of CFTR-modifying therapy

Aimee Joy Wiseman and Chee Y. Ooi

48: Nutritional therapy, pancreatic exocrine insufficiency, and pancreatic enzyme replacement therapy in cystic fibrosis: a protocol for clinical practice

Jefferson N. Brownell, Laura Padula, Elizabeth Reid, Virginia A. Stallings, Asim Maqbool,

49 EPIDEMIOLOGICAL IMPACT OF PANCREATIC CANCER

Patrick Maisonneuve

50 Molecular and genetic basis of pancreatic carcinogenesis: Which concepts are clinically relevant?

Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, Helmut Friess

51 New-onset diabetes as a harbinger of pancreatic cancer:

Is early diagnosis possible?

Dana K. Andersen, Suresh T. Chari, Eithne Costello, Tatjana Crnogorac-Jurcevic, Phil A. Hart, Anirban Maitra, Stephen J. Pandol

52 Pancreatic cancer screening: Target populations, methods and protocols for clinical practice

Christopher Paiji, Anne Marie Lennon, Elham Afghani

53 Clinical usefulness of biological markers in pancreatic cancer

David Anz, Ignazio Piseddu, Marlies Köpke, Ujjwal M. Mahajan, Julia Mayerle

54 Staging classification and stratification of pancreatic cancer for clinical practice

Akhil Chawla and Andrew J. Aguirre, MD, PhD

55 Imaging diagnosis and staging of pancreatic cancer: Which methods are essential and what information should they provide?

Megan H. Lee, Elliot K. Fishman

56 THE ROLE OF ENDOSCOPIC ULTRASOUND AND ASSOCIATED METHODS (ELASTOGRAPHY, CONTRAST ENHANCEMENT) IN THE DIAGNOSIS AND ASSESSMENT OF RESECTABILITY OF PANCREATIC CANCER

M. Giovannini

57 EUS-GUIDED FNA/FNB FOR PANCREATIC SOLID LESIONS: WHEN IS IT INDICATED AND WHAT IS THE OPTIMAL TECHNICAL APPROACH?

Mihai Rimbaș, Gianenrico Rizzatti and Alberto Larghi

58 Surgical treatment of resectable pancreatic cancer. What is the optimal strategy?

Jan G. D’Haese, Bernhard W. Renz, Jens Werner

59 Complications after pancreatic surgery. How to deal with them.

Tommaso Giuliani, Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi

60 Neoadjuvant treatment of pancreatic cancer: when and how?

Marta Sandini, Thilo Hackert, Ulla Klaiber, Markus W. Büchler, John P. Neoptolemos

61 Adjuvant therapy in pancreatic cancer : options, safety and outcomes

Jean-Luc Van Laethem

62 Management of pain in pancreatic cancer: An algorithm for clinical routine

J. Enrique Domínguez-Muñoz

63 EUS-guided celiac plexus neurolysis for pain in pancreatic cancer: when and how?

Jonathan M. Wyse, Anand V. Sahai,

64 The role of endoscopy in the management of unresectable pancreatic cancer

Jaimin Amin, Ajaypal Singh, and Irving Waxman

65 Chemotherapy for non-resectable pancreatic cancer

Raquel Fuentes, Juan José Serrano, Mercedes Rodríguez, Alfredo Carrato.

66 Diagnosis and management of pancreatic exocrine insufficiency in pancreatic cancer.

Sarah Powell-Brett, Keith J Roberts

67 Nutrition and Pancreatic Cancer

Mary Phillips, Oonagh Griffin

68 Present and future of local therapies for unresectable pancreatic cancer

Testoni Sabrina Gloria Giulia, Rossi Gemma, Archibugi Livia, Arcidiacono Paolo Giorgio

69 New pharmacological approaches for pancreatic cancer therapy: A light at the end of the tunnel?

Vineet K Gupta, Sulagna Banerjee and Ashok Saluja

70 Histologic classification of pancreatic cystic neoplasms

Giuseppe Zamboni, Anna Pesci

71 Incidental pancreatic cystic lesion: How to deal with it?

Atsushi Oba, Robert J. Torphy, Richard D. Schulick, and Marco Del Chiaro

72 Role of endoscopic ultrasound and endoscopic ultrasound-associated techniques in the diagnosis and differential diagnosis of pancreatic cystic tumors

María-Victoria Alvarez-Sánchez and Bertrand Napoléon

73 The role of multidetector CT, MRI and MRCP in the diagnosis and differential diagnosis of pancreatic cystic neoplasms

Megan H. Lee, Elliot K. Fishman

74 Intraductal papillary mucinous neoplasm (IPMN): When to observe, when to operate and optimal surgical approach

Zhi Ven Fong, Carlos Fernandez-del Castillo

75 Cystic tumours others than IPMN: When to observe, when to operate and optimal surgical approach

John W. Kunstman, James J Farrell

76 Pancreatic cystic tumors: any role for local therapies?

Julio Iglesias-Garcia

77. Diagnosis and treatment of pancreatic neuroendocrine tumours: how to deal with them in clinical practice

Francesca Muffatti, Stefano Partelli, Valentina Andreasi, and Massimo Falconi

78 OTHER LESS FREQUENT PANCREATIC TUMOURS: WHAT SHOULD BE KNOWN ABOUT CLINICAL FEATURES, DIAGNOSIS AND TREATMENT?

Rossana Percario, Paolo Panaccio, Fabio F. di Mola, Pierluigi Di Sebastiano and Tommaso Grottola

79 Diagnosis and therapy of exocrine pancreatic insufficiency after gastric and pancreatic surgery

Raffaele Pezzilli

80 Pancreatic exocrine insufficiency in type 1 and type 2 diabetes mellitus: Lessons from pancreatologists to diabetologists

Philip D Hardt

Chapter 81 Diabetes mellitus related to diseases of the exocrine pancreas (pancreatogenic diabetes): diagnosis and treatment.

David Bradley, Phil A. Hart

Index

Since the first edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of translational research and the “from bench to bedside” concept, much progress from the lab has been applied to clinical practice. Additionally, several highly relevant clinical trials published over the last decade have resulted in the updating and optimisation of clinical guidelines. 

A new and validated classification of the severity and complications of acute pancreatitis that is firmly rooted in clinical practice has become the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Increased study of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years, is especially important. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. Updates based on these developments and more are included in the new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons.

This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons is a result of the collaboration between the world's leading experts in each area of clinical pancreatology, with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their daily clinical practice. This book is an indispensable update providing leading knowledge in clinical pancreatology.

Professor J. Enrique Domínguez-Muñoz received his PhD in medicine from the University of Alcalá de Henares in Madrid in 1990. In 1998, he became Director of the Department of Gastroenterology and Hepatology at the University Hospital of Santiago de Compostela, Spain, where he is also a Professor of Medicine. He is also permanent member of the Royal Academy of Medicine of Galicia. He has published more than 300 papers in peer-reviewed journals and has edited 12 books. He was also elected President of the European Pancreatic Club, to take effect in 2024.