Harper's Textbook of Pediatric Dermatology, 2 Vols.

Contributors

Preface to the fourth edition

Dedication Arnold Oranje

Acknowledgements

Abbreviations

 

 

Section 1 Development, Structure and Physiology of the Skin

1. Embryogenesis of the Skin
   Lara Wine Lee & Karen A. Holbrook
2. Molecular Genetics in Paediatric Dermatology
   Anna C. Thomas & Veronica A. Kinsler
3. Cutaneous Microbiome
   Carrie C. Coughlin & William H. McCoy
4. Physiology of Neonatal Skin
   Peter H. Hoeger

Section 2 Skin Disorders of the Neonate and Young Infant

1. Neonatal skin care
   Peter H. Hoeger
2. Transient skin disorders
   Margarita Larralde & Maria Eugenia Abad
3. Congenital and Acquired Infections in the Neonate
   Scott H. James, Nico G. Hartwig, David W. Kimberlin and Peter H. Hoeger
4. Transplacentally acquired dermatoses
   Paula Carolina Luna
5. Developmental anomalies
   Henning Hamm & Marion Wobser
6. Differential Diagnosis of Neonatal Erythroderma
   Hagen Ott & Peter H. Hoeger
7. Vesiculopustular, bullous and erosive diseases of the neonate
   Anna Martinez & Caroline Mahon
8. Iatrogenic Disorders of the Newborn
   Elia F. Maalouf & Wilson Lopez

Section 3 Atopic Dermatitis and Related Disorders

1. Epidemiology of Atopic Dermatitis
   Carsten Flohr, Jonathan Silverberg, Joy Wan & Sinéad M. Langan
2. Genetics of Atopic Eczema
   Elke Rodriguez & Stephan Weidinger
3. Clinical Features and Diagnostic Criteria of Atopic Dermatitis
   Sinéad M. Langan & Hywel C. Williams
4. Severity Scoring and Quality of Life Assessment in Atopic Dermatitis
   Christian Apfelbacher, Cecilia A.C. (Sanna) Prinsen, Daniel Heinl & Hywel C. Williams
5. Atopic dermatitis and related disorders: Special types of presentation
   Nawaf Almutairi
6. Atopic dermatitis: Complications
   Kevin B. Yarbrough & Eric L. Simpson
7. Management of Atopic Dermatitis
   Lea Solman & Mary Glover

Section 4 Other Types of Dermatitis

1. Napkin dermatitis
   Arnold P. Oranje, Ernesto Bonifazi, Paul J. Honig & Albert C. Yan
2. Adolescent Seborrheic Dermatitis
   Roselyn Kellen, Nanette Silverberg
3. Irritant contact dermatitis
   David Luk
4. Allergic contact dermatitis
   Sharon E Jacob, Hannah Hill, & Alina Goldenberg
5. Hypereosinophilic disorders
   Eirini E. Merika & Nerys Roberts
6. Juvenile plantar dermatosis
   John C. Browning & Margaret Brown
7. Perioral dermatitis
   Marius Rademaker

Section 5 Psoriasis

1. Psoriasis – Epidemiology
   Matthias Augustin & Marc Alexander Radtke
2. Psoriasis: Aetiology and pathogenesis
   Jonathan Barker
3. Psoriasis: Classification, Scores, Diagnosis
   Nirav Patel & Megha Tollefson
4. Psoriasis: Clinical Features and Comorbidities
   Derek H. Chu & Kelly M. Cordoro
5. Psoriasis: Management
   Marieke M.B. Seyger

Section 6 Other papulosquamous disorders

1. Pityriasis rubra pilaris
   Liat Samuelov & Eli Sprecher
2. Lichen Planus
   Vibhu Mendiratta & Sarita Sanke
3. Lichen nitidus
   Jasem M. Alshaiji
4. Lichen striatus
   Franck Boralevi & Alain Taieb
5. Pityriasis rosea

Antonio A. T. Chuh & Vijay Zawar

Section 7 Bacterial skin Infections

1. Pyodermas and Bacterial Toxin-mediated Syndromes
   James R. Treat, Christian R. Millett, Warren R. Heymann & Steven M. Manders
2. Cutaneous manifestations of Gram negative infections
   Saul N. Faust, Diane Gbesemete & Robert S. Heyderman
3. Pitted keratolysis, erythrasma, erysipeloid
   Zhe xu, Yuanyuan Xiao, Ying liu, Lin Ma
4. Lyme Borreliosis
   Susan O’Connell
5. Bartonella infections
   Sonia Kamath & Minnelly Luu
6. Mycobacterial Skin Infections
   G Sethuraman, Tanvi Dev, and V Ramesh
7. Rickettsial disease
   Arun C. Inamadar & Aparna Palit
8. Endemic Treponematoses: Yaws, Pinta and Endemic Syphilis
   Herman Jan H. Engelkens
9. Tropical ulcer
   Vibhu Mendiratta & Soumya Agarwal

Section 8 Fungal skin infections

1. Superficial fungal infections
   Peter Mayser & Yvonne Gräser
2. Deep Fungal Infections
   María Teresa García-Romero

Section 9 Viral skin infections and opportunistic infections

1. Molluscum contagiosum
   Joachim J. Bugert, Ali Alikhan & Tor Shwayder
2. Human Papillomavirus Infection
   Yun Tong, Stephen K. Tyring, Zsuzsanna Z. Szalai
3. Herpes Simplex Virus Infections
   Manuraj Singh, Helen M. Goodyear, Judith Breuer
4. Varicella-zoster virus infections
   Manuraj Singh & Judith Breuer
5. Poxviruses
   Sue Lewis-Jones & Jane Sterling
6. HIV and HTLV-1 Infection
   Neil S. Prose, Ncoza C. Dlova, Rosalia A. Ballona & Coleen K. Cunningham
7. Viral exanthemas
   Pamela Gangar, Jusleen Ahluwalia & Sheila Fallon Friedlander
8. Eruptive hypomelanosis
   Vijay Zawar & Antonio A. T. Chuh
9. Cutaneous Infections in Immunocompromised Children
   Miriam Weinstein, Hagen Ott & Peter H. Hoeger

Section 10 Parasitic skin infestations and sting reactions

1. Leishmaniasis
   Bernardo Gontijo and Carolina Talhari
2. Helminthic infections
   Hector Cáceres-Ríos & Felipe Velasquez
3. Scabies and Pseudoscabies
   Wingfield E. Rehmus & Julie S. Prendiville
4. Pediculosis and Cimicosis
   Sandipan Dhar & Sahana M. Srinivas
5. Noxious and venomous creatures
   K L E Hon, TNH Leung & T F Leung
6. Aquatic dermatoses
   Sarah Hill

Section 11 Urticaria, erythemas and drug reactions

1. Urticaria, erythemas and drug reactions
   Bettina Wedi
2. Annular erythemas
   Kimberly A. Horii
3. Giannotti-Crosti Syndrome
   Carlo M. Gelmetti
4. Erythema Multiforme, Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
   Benjamin S Daniel, Lizbeth Ruth Wheeler & Dédée F. Murrell
5. Hypersensitivity reactions to drugs
   Mohannad AbuHilal & Neil Shear

Section 12 Acne and acneiform disorders

1. Acne
   Marissa J. Perman, Bodo C. Melnik, Anne W. Lucky
2. Rosacea
   Clio Dessinioti & Andreas Katsambas
3. Hidradenitis suppurativa
   P. Theut Riis & G.B.E. Jemec

Section 13 Nutritional disorders

1. Skin Manifestations of Nutritional Disorders
   Carola Durán McKinster & Luz Orozco-Covarrubias
2. Skin Manifestations of Paediatric Metabolic Syndrome
   Gregor Holzer & Beatrix Volc-Platzer

Section 14 Blistering disorders

1. Differential diagnosis of vesiculobullous lesions
   Sharleen F. Hill and Dedee F. Murrell
2. Autoimmune bullous diseases
   Nina van Beek & Enno Schmidt
3. Childhood Dermatitis Herpetiformis
   Carmen Liy Wong & Irene Lara-Corrales
4. Epidermolysis bullosa and Kindler syndrome
   Jemima E. Mellerio, Anna E. Martinez & Christina Has

Section 15 Photodermatoses, photoprotection and environmental skin disorders

1. The Idiopathic Photodermatoses and Skin Testing
   Erhard Hölzle & Robert Dawe
2. The Porphyrias
   Jorge Frank
3. Photoprotection
   Lachlan Warren & Genevieve Casey
4. Skin Reactions to Plants, Cold, Heat, and Chemicals
   Tuyet A. Nguyen, Christopher Lovell & Andrew C. Krakowski

Section 16 Granulomatous diseases

1. Sarcoidosis
   Lisa M. Arkin, Julie L. Cantatore-Francis & Julie V. Schaffer
2. Granuloma annulare
   Annalisa Patrizi & Iria Neri
3. Orofacial granulomatosis
   Lisa Weibel & Martin Theiler

Section 17 Neutrophilic dermatoses

1. Sweet syndrome
   Peter von den Driesch
2. Pyoderma gangrenosum
   Karolina Gholam

Section 18 Lymphocytic disorders

1. Pityriasis lichenoides
   Christine T. Lauren & Maria C. Garzon
2. Jessner Lymphocytic Infiltrate of the Skin
   R.M. Ross Hearn
3. Primary Cutaneous Lymphoma
   Rebecca Levy & Elena Pope
4. Childhood Leukaemias and Lymphomas
   Keith Morley & Jennifer Huang

Section 19 Histiocytic disorders

1. Langerhans cell histiocytosis
   Sylvie Fraitag & Jean Donadieu
2. Juvenile Xanthogranuloma and other Non Langerhans Cell Histiocytoses
   Gudrun Ratzinger & Bernhard W.H. Zelger

Section 20 Mastocytosis

1. Paediatric mastocytosis
   Laura Polivka & Christine Bodemer

Section 21 Disorders of connective tissue

1 Ehlers-Danlos-Syndrome
Nigel P. Burrows

2 Pseudoxanthoma Elasticum and Cutis Laxa
Sean D Reynolds & Lionel Bercovitch

3 Buschke-Ollendorff-Syndrome, Marfan Syndrome, Osteogenesis imperfect
Marc Lacour

4 Anetodermas and Atrophoderma
Marc Lacour

5 Hyalinoses, Stiff Skin Syndrome, Restrictive Dermopathy
David G. Paige

6 Striae in Children and Adolescents
Marcelo Ruvertoni

7 Morphoea (Localised Scleroderma)
Despina Eleftheriou & Lindsay Shaw

8 Systemic sclerosis in childhood
Christopher P. Denton & Carol M. Black

Section 22 Disorders of fat tissue

1. Lipoma and lipomatosis
   Siriwan Wananukul & Susheera Chatproedprai
2. Panniculitis
   Christine Bodemer
3. Lipodystrophies
   Robert K. Semple

Section 23 Mosaic disorders, naevi and hamartomas

1. An introduction to Mosaicism
   Veronica A. Kinsler
2. Melanocytic naevi
   Veronica A. Kinsler
3. Epidermal naevi
   Leopold M. Groesser & Christian Hafner
4. Other naevi and hamartomas
   Jonathan A. Dyer
5. Proteus syndrome and other localised overgrowth disorders
   Veronica A. Kinsler
6. Mosaic disorders of pigmentation
   Veronica A. Kinsler

Section 24 Non-vascular skin tumours

1. Differential diagnosis of skin nodules and cysts
   Susanne Abraham & Peter H. Hoeger
2. Adnexal disorders
   Andrew Wang & Robert Sidbury
3. Calcification and Ossification in the Skin
   Amanda T. Moon, Albert C. Yan, and Eulalia T. Baselga
4. Angiolymphoid Hyperplasia with Eosinophilia
   Jasem M. Alshaiji
5. Fibromatoses
   Jenna L. Streicher, Moise L. Levy, and Albert C. Yan
6. Carcinomas of the skin
   Karen Agnew
7. Childhood Melanoma
   Birgitta Schmidt & Elena B. Hawryluk
8. Other malignant skin tumours
   Andrea Bettina Cervini, Marcela Bocian, María Marta Bujan & Paola Stefano

Section 25 Vascular tumours and malformations

1. Vascular malformations
   Laurence M. Boon & Miikka Vikkula
2. Infantile haemangiomas
   Anna L. Bruckner, Ilona J. Frieden & Julie Powell
3. Other vascular tumours
   Ann M. Kulungowski, Taizo A. Nakano & Anna L. Bruckner
4. Disorders of lymphatics
   Arin K. Greene & Jeremy A. Goss

Section 26 Disorders of Pigmentation

1. Inherited and Acquired Hyperpigmentation
   Leslie Castelo-Soccio & Alexis Weymann Perlmutter
2. Vitiligo
   Julien Seneschal, Juliette Mazereeuw-Hautier & Alain Taïeb
3. Albinism
   Fanny Morice-Picard & Alain Taïeb
4. Disorders of hypopigmentation
   M.W. Bekkenk & A. Wolkerstorfer
5. Dyschromatosis
   Eli Sprecher & Liat Samuelov

Section 27 Disorders of Keratin and Keratinization

1. Review of Keratin Disorders
   Maurice A.M. van Steensel & Peter M. Steijlen
2. Mendelian Disorders of Cornification (MEDOC): the Keratodermas
   Edel A. O’Toole
3. Mendelian Disorders of Cornification (MeDOC): The ichthyoses
   Angela Hernandez, Robert Gruber, Vinzenz Oji
4. Keratosis pilaris and Darier´s Disease
   Flora B. de Waard-van der Spek & Arnold. P Oranje
5. The Erythrokeratodermas
   Juliette Mazereeuw-Hautier, S Leclerc-Mercier & E Bourrat
6. Netherton Syndrome
   Wei-Li Di & John Harper
7. Porokeratosis
   Leslie Castelo-Soccio

Section 28 Focal or generalized hypoplasia, premature ageing

1. Ectodermal dysplasia
   Cathal O’Connor, Yuka Asai & Alan D. Irvine
2. Focal dermal hypoplasia
   Bret L. Bostwick, Ignatia B. Van den Veyver & V. Reid Sutton
3. Incontinentia pigmenti
   Elizabeth A. Jones & Dian Donnai
4. Premature ageing syndromes
   Helga V. Toriello & Caleb P. Bupp

Section 29 Genetic diseases predisposing to malignancy

1. Xeroderma pigmentosum and related diseases
   Steffen Schubert & Steffen Emmert
2. Gorlin (Naevoid basal cell carcinoma) syndrome
   Kai Ren Ong & Peter Farndon
3. Rothmund–Thomson Syndrome, Bloom Syndrome, Dyskeratosis Congenita, Fanconi Anaemia, Poikiloderma with Neutropenia
   Lisa L. Wang & Moise L. Levy
4. Other Genetic Disorders Predisposing to Malignancy
   Julie V. Schaffer

Section 30 Neurofibromatosis, RASopathies, and Hamartoma-overgrowth-syndromes

1. The Neurofibromatoses
   Amy Theos, Kevin P. Boyd, and Bruce R. Korf
2. Tuberous Sclerosis Complex
   Francis J. DiMario Jr.
3. Other RASopathies
   Fanny Morice-Picard

Section 31 Vasculitic and Rheumatic Syndromes

1. Cutaneous vasculitis
   Joyce C Chang & Pamela F. Weiss
2. Purpura fulminans
   Saul N. Faust, Brian Eley, Michael Levin
3. Kawasaki disease
   Wynnis L. Tom & Jane C. Burns
4. Polyarteritis Nodosa, Granulomatosis with Polyangiitis, and Microscopic Polyangiitis
   Paul A. Brogan
5. Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus and Juvenile Dermatomyositis
   Elena Moraitis & Despina Eleftheriou
6. Behçet’s Disease and Relapsing Polychondritis
   Sibel Ersoy-Evans, Ayşen Karaduman, Seza Özen
7. Erythromelalgia
   Nedaa Skeik

Section 32 Cutaneous Manifestations of Systemic Disease

1. Metabolic Disorders and the Skin
   Fatma Al Jasmi & Hassan Galadari, Peter T. Clayton & Emma J. Footitt
2. Cystic Fibrosis
   Roderic J Phillips
3. Cutaneous manifestations of endocrine disease
   Devika Patel & Tor A. Shwayder
4. Autoinflammatory diseases and amyloidosis
   Antonio Torrelo, Sergio Hernández-Ostiz & Teri A. Khan
5. Immunodeficiency syndromes
   Julie V. Schaffer, Melanie Makhija & Amy S. Paller
6. Graft-Versus-Host Disease
   John Harper & Paul Veys

Section 33 The oral cavity

1. The Oral Mucosa and Tongue
   Jane Luker & Crispian Scully

Section 34 Hair, scalp and nail disorders

1. Hair Disorders
   Elise A. Olsen & Matilde Iorizzo
2. Alopecia areata
   Kirsten Foitzik-Lau
3. Nail disorders
   Antonella Tosti & Bianca Maria Piraccini

Section 35 Anogenital disease in children

1. Genital disease in children
   Gayle O. Fischer
2. Sexually transmitted diseases in children and adolescents
   Arnold P. Oranje, Robert A.C. Bilo & Nico G. Hartwig

Section 36 Cutaneous Signs of Child Maltreatment and Sexual Abuse

1. Maltreatment, physical and sexual abuse
   Bernhard Herrmann

Section 37 Psychological Aspects of Skin Disease in Children

1. Assessing and scoring Life Quality
   Andrew Y Finlay
2. Coping with the burden of disease
   Sarah L. Chamlin
3. Physiological Habits, Self-Mutilation and Factitious Disorders
   Arnold P. Oranje, Jeroen Novak & Robert A.C. Bilo

Section 38 Principles of treatment in children

1. Topical therapy
   Johannes Wohlrab
2. Systemic therapy in Pediatric Dermatology
   Blanca Rosa Del Pozzo-Magana & Irene Lara-Corrales
3. New genetic approaches to treating diseases of the skin.
   Stephen Hart & Amy Walker
4. Surgical therapy
   Julianne A. Mann & Jane S. Bellet
5. Laser therapy
   Samira Batul Syed, Maria Gnarra & Sean Lanigan
6. Sedation and anaesthesia
   Brenda M. Simpson,Yuin-Chew Chan, & Lawrence F. Eichenfield

Section 39 Diagnostic procedures in dermatology

1. Approach to the pediatric patient
   Diana Purvis
2. Dermoscopy of Melanocytic Lesions in the Paediatric Population
   Maria L Marino, Jennifer L. DeFazio, Ralph P. Braun & Ashfaq A. Marghoob
3. The Role of Histopathology and Molecular Techniques in Pediatric Dermatology
   Lori Prok & Adnan Mir

Section 40 Nursing care of cutaneous disorders in children

1. Nursing Care of the Skin in Children
   Bisola Laguda, Hilary Kennedy, Jackie, Denyer, Heulwyn Wyatt, Jean Robinson & Kathryn Pett

Index

 

A consummate classic with a fresh approach to pediatric dermatology 

Children's skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment.

This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions? both common and rare ? with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data ? especially at the genetic level.

This new fourth edition includes:

• Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants
• Increased coverage of lasers and other technologies used to treat skin disease
• More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management
• Additional online features, including patient information links and multiple choice questions

Harper?s Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Prof. Dr. Peter H. Hoeger, Head of the Departments of Pediatrics and Pediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, and  Professor of Pediatrics and Dermatology, University of Hamburg, Germany; Dr. Veronica Kinsler, Consultant Paediatric Dermatologist and Academic Lead Clinician, Paediatric Dermatology Department, Great Ormond Street Hospital for Children and Associate Professor, Genetics and Genomic Medicine, University College London Institute of Child Health, London, UK; Albert C. Yan, Professor of Pediatrics and Dermatology and Chief of Pediatric Dermatology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Prof. John Harper, Honorary Professor of Paediatric Dermatology, University College London, Institute of Child Health / Great Ormond Street Hospital, London, UK; Prof. Dr. Arnold P. Oranje, formerly Consultant in General and Pediatric Dermatology and Professor of Pediatric Dermatology, Department of Pediatrics, Erasmus Medical Center, Rotterdam, Netherlands; Christine Bodemer, Professor in Dermatology and Coordinator, French Centre for Genetic Skin Diseases, Centre de reference sur les Maladies Genetiques a Expression Cutanee (MAGEC), Hopital Necker-Enfants Malades, Paris, France; Dr. Margarita Larralde, Tenured Professor of Dermatology at the University of Buenos Aires (UBA) and Director of the Carrera d de Medicos Specialists in Pediatric Dermatology at Ramos Mejia Hospital Headquarters, Buenos Aires, Argentina; David Luk, Consultant Pediatrician, Department of Pediatrics, United Christian Hospital, Kwun Tong, Hong Kong; Vibhu Mendiratta, Professor of Dermatology, Lady Hardinge Medical College, Delhi, India and Diana Purvis, Paediatric Dermatologist, Starship Children?s Health, Auckland, New Zealand