Inflammatory Bowel Diseases. a Clinician's Guide

Description

Inflammatory Bowel Diseases: A Clinician’s Guide provides practical guidance for the diagnosis and management of those suspected or known to have one of the forms of these complex diseases. It is perfect both for gastroenterologytrainees learning to care for these patients and the experienced physician as a concise and practical resource for day to day use.

Written by the experts, Inflammatory Bowel Diseases: A Clinician’s Guide is an essential tool for all gastroenterologists managing patients with inflammatory bowel disease.

Contents

Foreword

Preface

Section I – Pathogenesis and Clinical Features

Chapter 1: Epidemiology and Pathogenesis

Epidemiology

Pathogenesis

Genetics

Microbiome

Environment

Chapter 2: Clinical Features and Diagnosis of Crohn’s disease

Clinical features

Natural history

Diagnosis

History and physical examination

Laboratory investigations

Serologic markers

Endoscopy

Imaging

Chapter 3: Clinical Features and Diagnosis of ulcerative colitis

Clinical features

Natural history

Diagnosis

History and physical examination

Laboratory investigations

Serologic markers

Endoscopy

Imaging

Differential diagnosis

Chapter 4: Extra intestinal Manifestations of IBD

Arthritis and Arthropathy

Cutaneous manifestations

Hepatobiliary disease

Ophthalmologic manifestations

Renal manifestations

Thromboembolic and cardiovascular risk

Section II – Therapeutic Agents

Chapter 5: Aminosalicylates

Efficacy in Ulcerative colitis

Efficacy in Crohn’s disease

Safety

Chapter 6: Corticosteroids

Efficacy in Ulcerative colitis

Efficacy in Crohn’s disease

Safety

Chapter 7: Immunomodulators

Thiopurines

Efficacy in Ulcerative colitis

Efficacy in Crohn’s disease

Safety

Methotrexate

Efficacy in Ulcerative colitis

Efficacy in Crohn’s disease

Safety

Calcineurin inhibitors

Efficacy in ulcerative colitis

Efficacy in Crohn’s disease

Chapter 8: Biologics

Infliximab

Efficacy in Ulcerative colitis

Efficacy in Crohn’s disease

Safety

Adalimumab

Efficacy in Ulcerative colitis

Efficacy in Crohn’s disease

Certolizumab pegol

Efficacy in Crohn’s disease

Golimumab

Natalizumab

Vedolizumab

Newer Therapies

Chapter 9: Antibiotics                                                   

Efficacy in Ulcerative colitis

Efficacy in Crohn’s disease

Other microbial modification methods – probiotics and fecal microbiota transplantation

Section III - Management

Chapter 10: Medical Management of Ulcerative colitis

Assessment of extent, activity, and severity

Limited colitis – proctitis, proctosigmoiditis, and left-sided colitis

Pancolitis

Mild to moderate disease

Moderate to severe disease

Severe disease

Chapter 11: Medical Management of Crohn’s Disease

Mild to moderate disease

Moderate to severe disease

Chapter 12: Surgical Management of Inflammatory Bowel Diseases

Surgery for ulcerative colitis

Pouch-related complications in ulcerative colitis

Surgery for Crohn’s disease

Prophylaxis for prevention of postoperative recurrence in Crohn’s disease

Chapter 13: Complications of IBD

Complications of ulcerative colitis

Toxic megacolon and perforation

Colonic Strictures

Clostridium difficile and cytomegalovirus colitis

Colorectal dysplasia and cancer

Complications of Crohn’s disease

Fibrostenosis and strictures

Abscesses

Fistulizing Crohn’s disease

Small bowel cancer

Section IV – Special Considerations

Chapter 14: Nutrition in IBD

Malnutrition and micronutrient deficiencies

Dietary Therapies for IBD

Chapter 15: Pregnancy, Conception and Childbirth

Fertility

Effect of pregnancy on disease

Effect of disease on pregnancy

Maternal Medication use during pregnancy

Paternal Medication use

Inheritance

Chapter 16: Inflammatory bowel disease during childhood and adolescence

Epidemiology and clinical features

Treatment of pediatric IBD

Very early onset IBD

Transition of Care

References

Index

Author Information

Ashwin N Ananthakrishnan MD, MPH, Co-Director, Crohn’s and Colitis Center, Massachusetts General Hospital, Assistant Professor of Medicine, Harvard Medical School, USA

Ramnik J Xavier, MD, Chief, Gastrointestinal Unit, Director, Center for the Study of Inflammatory Bowel Disease, Kurt Isselbacher Professor of Medicine, Harvard Medical School, USA

Daniel K Podolsky, MD,  President, Professor of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA