Developmental Neuropathology

List of contributors

Introduction

Chapter 1: CNS Manifestations of Chromosomal Change
Chapter 2: Neural tube defects
Chapter 3: MIDLINE PATTERNING DEFECTS
Chapter 4: MICROCEPHALY
Chapter 5: Hemimegalencephaly and Dysplastic Megalencephaly
Chapter 6: Lissencephaly, Type I
Chapter 7: Lissencephaly, Type II (Cobblestone Lissencephaly)
Chapter 8: Polymicrogyria
Chapter 9: Cerebral Heterotopia
Chapter 10: Hippocampal sclerosis and granule cell dysplasia, and cortical dysplasia
Chapter 11: Tuberous Sclerosis Complex
Chapter 12: Chiari Malformations
Chapter 13: Dandy-Walker Malformation, Mega-Cisterna Magna, and Blake's Pouch Cyst
Chapter 14: Joubert Syndrome
Chapter 15: Cerebellar Heterotopia and Dysplasia
Chapter 16: Brainstem Malformations
Chapter 17: SPINAL CORD LESIONS
Chapter 18: HYDROCEPHALUS
Chapter 19: Antenatal Disruptive Lesions
Chapter 20: Hemorrhagic Lesions
Chapter 21: White Matter Lesions in the Perinatal Period
Chapter 22: Gray Matter Lesions
Chapter 23: Pediatric Head Injury
Chapter 24: Pediatric Vascular Malformations
Chapter 25: Sudden Infant Death Syndrome
Chapter 26: Kernicterus
Chapter 27: Lesions Induced by Toxins
Chapter 28: Disorders of Carbohydrate Metabolism
Chapter 29: Sphingolipidoses and related disorders
Chapter 30: The Neuronal Ceroid-Lipofuscinoses
Chapter 31: Peroxisomal Disorders
Chapter 32: Mitochondrial Disorders
Chapter 33: DISORDERS OF AMINO ACID METABOLISM AND CANAVAN DISEASE
Chapter 34: Pelizaeus-Merzbacher Disease
Chapter 35: Cockayne Syndrome
Chapter 36: VANISHING WHITE MATTER DISEASE
Chapter 37: Alexander Disease
Chapter 38: Pathology and Genetics of Neuroaxonal Dystrophy/ Neurodegeneration with Brain Iron Accumulation
Chapter 39: Spinal Muscular Atrophy
Chapter 40: Autism Spectrum Disorders
Chapter 41: Intrauterine Infections
Chapter 42: Perinatal and Postnatal Infections
Chapter 43: Rasmussen Encephalitis

A definitive, clinically oriented guide to the pathology of genetics of developmental neuropathology

Developmental neuropathology relates to the wide range of disorders affecting the developing brain or pre- and post-natal life, with emphasis on the genetic and molecular mechanisms involved. This book provides a practical guide to diagnosing and understanding these disorders affecting this vulnerable population and potentially stimulates further advances in this exciting area. It also addresses the controversies in inflicted head injury in infants.

The fourth major title to be approved by the International Society of Neuropathology (ISN), Developmental Neuropathology offers in-depth chapter coverage of brain development; chromosomal changes; malformations; secondary malformations and destructive pathologies; developmental vascular disorders; acquired metabolic and exogenous toxins; metabolic disorders; Rett syndrome and autism; and infectious diseases. The text provides:

• Clinical, disease-oriented approach to the pathology and genetics developmental neuropathology
• Fuses classical and contemporary investigative approaches
• Includes genetic and molecular biological pathogeneses
• Fully illustrated
• Approved and endorsed by International Society of Neuropathology

Developmental Neuropathology is the perfect book for practicing neuropathologists, pediatric pathologists, general pathologists, neurologists, and geneticists in deciphering the pathology and pathogenesis of these complex disorders affecting the nervous system of the embryo, fetus, and child.