Signaling Pathways in Liver Diseases

Description

Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.

With increased focus on the comprehension of cellular mechanisms involved in steatohatitis, cirrhosis and liver tumours, which has led in changes to the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:

• Autophagy
• Notch Pathway
• PI3K/PTEN Signaling in Liver Diseases
• Sirtuins
• Hepcidin and Iron
• Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis
• Oxidative Stress and Signaling in the Liver

Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom will provide write a clear yet comprehensive review of their chosen topic. Chapters will contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.

Signalling Pathways in Liver Diseases 3E is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Contents

List of Contributors, vii

1 Hepatocytes 1
Jean-François Dufour and Joachim C. Mertens
2 Signaling pathways in biliary epithelial cells 15
M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson
3 Stellate cells 34
Alessandra Caligiuri and Fabio Marra
4 Kupffer cells 61
Amirali Kiyani and Ekihiro Seki
5 Hepatic sinusoidal endothelial cells 73
Moira B. Hilscher Robert C. Huebert and Vijay H. Shah
6 Extracellular matrix 85
Scott L. Friedman
7 Platelets: a new cell type in liver physiology 97
Mickaël Lesurtel and Pierre ]Alain Clavien
8 Immune cell communication in liver disease and liver regeneration 110
R. Harminder Boghal, B.F. Stephenson and Simon C. Afford
9 Extracellular vesicle RNA in liver disease 130
Tushar Patel and Hiroaki Haga
10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease 139
Fabienne Foufelle and Pascal Ferré
11 Autophagy 151
Hao Zhang, Bilon Khambu and Xiao ]Ming Yin
12 CXC chemokine receptor signaling in liver repair and regeneration 166
Gregory C. Wilson, Christopher M. Freeman, Hiroyuki Nojima and Alex B. Lentsch
13 Metabolic regulation of liver regeneration 174
Jiansheng Huang and David A. Rudnick
14 TNF signaling 186
Amrit Mann, Mark J. Czaja and Jörn M. Schattenberg
15 Fas/FasL 203
Maria Eugenia Guicciardi and Gregory J. Gores
16 Interferon signaling 214
Markus H. Heim
17 Endocannabinoid signaling in liver pathologies 226
Bostjan Humar and Nasser Semmo
18 The WNT/ß ]catenin pathway 240
Satdarshan P. Singh Monga
19 Hedgehog signaling in the liver 262
Mariana V. Machado and Anna Mae Diehl
20 Notch pathway 275
Sonja Rothweiler and David Semela
21 PI3K/PTEN signaling in liver diseases 287
Alfredo Fort, Nicolas Calo, Dorothea Portius, Lucie Bourgoin, Marion Peyrou and Michelangelo Foti
22 mTOR signaling in liver disease 314
Marion Cornu, Grégoire de Caudron de Coquereaumont and Michael N. Hall
23 LKB1/AMPK pathway in the control of hepatic energy metabolism 326
Benoit Viollet and Marc Fortes
24 NF-?B 339
Ekihiro Seki and David A. Brenner
25 c-Jun NH2 ]terminal kinases in liver diseases 348
Johannes Kluwe and Robert F. Schwabe
26 p53 364
Aundrietta D. Duncan, Wen ]Wei Tsai and Michelle Craig Barton
27 Sirtuins 374
Frank K. Huynh, Eoin McDonnell, Kristin A. Anderson and Matthew D. Hirschey
28 Bile acids and their receptors 385
Thierry Claudel and Michael Trauner
29 Hepcidin and iron 400
Chiara Vecchi and Antonello Pietrangelo
30 Gut microbiome and liver diseases 411
Herbert Tilg and Alexander R. Moschen
31 Epigenetic regulation of hepatic stellate cells and liver fibrosis 421
Jelena Mann and Derek A. Mann
32 Signaling in hepatocellular carcinoma 435
Adam Pennycuick and Augusto Villanueva
33 Interplay between hepatitis B virus and innate immune signaling pathways 448
Barbara Testoni, David Durantel and Fabien Zoulim
34 Signaling of hepatitis C virus 459
Joachim Lupberger, Nicolaas Van Renne and Thomas F. Baumert
35 Oxidative stress and signaling in the liver 469
Mitchell R. McGill, Yuchao Xie and Hartmut Jaeschke
Index

Authors

Professor Jean-François Dufour, MD, PhD, Chief, Department of Clinical Pharmacology, University Clinic Visceral Surgery and Medicine, Bern, Switzerland.

Professor Dufour is on the governing board of the European Association for the Study of the Liver (EASL). He also serves as Associate Editor for the Wiley journal Liver International and is on the editorial board for the following journals: Journal of Hepatology; Clinical Science; World Journal of Gastroenterology

Professor Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland.

Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award.