Cancer Consult. Expertise for Clinical Practice

Description

The field of oncology benefits from several large-scale reference books and a host of monographs dedicated to specific cancers. However, truly excellent practice and review books are, surprisingly, quite scarce. Outside of a scant handful of books and online reference tools that offer clinical response practice and board review in a basic question and answer format, there are no resources that offer a robust, engaging, fully referenced tool for these vital activities in every oncologist’s and oncology trainee’s work. This print and electronic book seeks to fill that void, offering comprehensive question-and-answer style content that covers the entire specialty of oncology and provides practicing oncologists with a fascinating and immediately applicable compendium of vital information dealing with a well-balanced selection of common and uncommon cancers. At the heart of this book is the editor’s and authors’ desire to overcome the controversies and barriers to practice that usually emerge following the appearance of new data. In every section, the user is guided toward collaboration in ongoing clinical research – for example, via discussions of well-designed ongoing clinical trials in each specific area.

Developed with both the teacher and learner in mind, this book also offers trainees and fellows an excellent opportunity to enhance their preparation for the ABIM oncology fellowship exam as well as for the oncology boards. It will also be an extremely useful tool for oncologists working toward the recertification exam. This comprehensive, beefy book includes hundreds of painstakingly developed multiple-choice and mini-case-based questions covering the principles of medical oncology, malignant hematology, surgical oncology, and radiation oncology. It also contains mini-cases and questions dealing with the biology, diagnosis, classification, staging, and multidisciplinary treatment of cancers at every anatomic site. The very latest topics are included, such as molecular techniques, targeted therapies, and translational cancer research. Concise but detailed answers are referenced to key journals and books, and evidence-based wherever possible. NCCN guidelines are also referenced as appropriate. With its powerful focus on take-home messages from and for actual clinical work, this book will help keep oncologists up to date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base.

Table of contents

List of Contributors
Preface

Section 1 | Malignant Hematology and Hematopoietic Cell Transplantation

Part 1 | Acute Lymphoblastic Leukemia in Adults

• 1 Diagnosis of acute lymphoblastic leukemia, 5
  Frederick G. Behm, Agatha Bogard, Syed A. Abutalib, and Sujata S. Gaitonde
• 2 Prognostic markers and models in acute lymphoblastic leukemia, 18
  Dieter Hoelzer
• 3 Management of B-cell acute lymphoblastic leukemia, 22
  Hady Ghanem, Hagop Kantarjian, Nitin Jain, and Elias Jabbour
• 4 Management of T-cell acute lymphoblastic leukemia, 29
  Daniel J. DeAngelo
• 5 Minimal residual disease in acute lymphoblastic leukemia, 35
  Meir Wetzler
• 6 Hematopoietic cell transplantation in adult acute lymphoblastic leukemia, 40
  Netanel A. Horowitz and Jacob M. Rowe

Part 2 | Acute Myeloid Leukemia in Adults

• 7 Prognosis in acute myeloid leukemia: cytogenetics and beyond, 51
  Gordana Raca, Madina Sukhanova, and Lucy A. Godley
• 8 Induction therapy in acute myeloid leukemia, 58
  Tapan Kadia and Farhad Ravandi
• 9 Consolidation therapy in acute myeloid leukemia, 67
  Gregory K. Behbehani and Bruno C. Medeiros
• 10 Management of acute promyelocytic leukemia, 71
  Eytan M. Stein and Martin S. Tallman
• 11 Minimal residual disease in acute myeloid leukemia, 76
  Hans Beier Ommen, Line Nederby, Marie Toft-Petersen, Charlotte Guldborg Nyvold, and Peter Hokland
• 12 Relapsed and refractory acute myeloid leukemia, 82
  Stefan H. Faderl
• 13 Hematopoietic cell transplantation in acute myeloid leukemia, 89
  Antonio M. Jimenez and Stefan O. Ciurea

Part 3 | Myelodysplastic Syndromes and Related Disorders

• 14 Pitfalls in the diagnosis of myelodysplastic syndromes, 99
  Jay Yang, Gail Bentley, and Charles A. Schiffer
• 15 Cytogenetics and prognostic models in myelodysplastic syndromes, 106
  Uma Borate and Harry P. Erba
• 16 Management of myelodysplastic syndromes, 113
  Vu H. Duong, Alan F. List, and Rami S. Komrokji
• 17 Management of therapy-related myeloid neoplasms, 120
  Jagoda K. Jasielec and Richard A. Larson
• 18 Hematopoietic cell transplantation in myelodysplastic syndromes, 126
  Antonio Di Stasi, Armin Ghobadi, and Partow Kebriaei
• 19 Acquired aplastic anemia, 131
  Valeria Visconte and Ramon V. Tiu

Part 4 | Myeloproliferative Neoplasms

• 20 Diagnostic approach in myeloproliferative neoplasms, 137
  Ayalew Tefferi
• 21 Chronic myeloid leukemia: chronic phase, 142
  Jerald P. Radich
• 22 Blast crisis of chronic myeloid leukemia, 147
  Michael J. Mauro
• 23 Chronic myeloid leukemia and pregnancy, 150
  Michael J. Mauro
• 24 Polycythemia vera, 152
  Constantine S. Tam and Srdan Verstovsek
• 25 Essential thrombocytosis, 156
  Paola Guglielmelli and Alessandro M. Vannucchi
• 26 Primary myelofibrosis, 162
  Ayalew Tefferi
• 27 Eosinophilic myeloproliferative disorders, 167
  Jason Gotlib
• 28 Chronic myelomonocytic leukemia, 176
  Mrinal M. Patnaik
• 29 Hematopoietic cell transplantation in chronic myeloid leukemia, 180
  Jerald P. Radich
• 30 Hematopoietic cell transplantation in primary myelofibrosis, 187
  Irum Khan and Damiano Rondelli

Part 5 | Chronic Lymphocytic and Other Leukemias

• 31 Prognostic markers and management of chronic lymphocytic leukemia, 195
  Courtney D. DiNardo and Susan O’Brien
• 32 Hematopoietic cell transplantation in chronic lymphocytic leukemia, 201
  Michael R. Bishop
• 33 Prolymphocytic leukemia, 207
  Claire Dearden
• 34 Hairy cell leukemia, 220
  Justin M. Watts and Martin S. Tallman

Part 6 | Hodgkin Lymphoma

• 35 Management of classical Hodgkin lymphoma, 229
  Kristen Sanfi lippo and Nancy L. Bartlett
• 36 Nodular lymphocyte-predominant Hodgkin lymphoma, 235
  Dennis A. Eichenauer
• 37 Hematopoietic cell transplantation in Hodgkin lymphoma, 240
  Tsiporah Shore and Koen van Besien

Part 7 | Non-Hodgkin’s Lymphomas

• 38 Pitfalls in the diagnosis of non-Hodgkin’s lymphomas, 247
  Carmen Barcena and Laurence de Leval
• 39 Follicular lymphoma, 257
  Myron S. Czuczman
• 40 Diffuse large B-cell lymphoma, 263
  Andrew D. Zelenetz
• 41 Mantle cell lymphoma, 270
  Stephen Smith and John Sweetenham
• 42 Marginal zone lymphoma, 275
  Sarah Rutherford, Wayne Tam, and Peter Martin
• 43 Primary mediastinal large B-cell lymphoma, 282
  Pier Luigi Zinzani
• 44 Burkitt lymphoma, 286
  Mark Roschewski and Wyndham Wilson
• 45 Gray zone lymphoma, 290
  Caron A. Jacobson and Ann S. LaCasce
• 46 Transformed lymphoma, 295
  Stephane Doucet and Jane N. Winter
• 47 HIV-associated lymphoma, 304
  Kieron Dunleavy
• 48 Primary CNS lymphoma, 308
  Nicholas A. Blondin, Joachim M. Baehring, and Fred H. Hochberg
• 49 Primary cutaneous lymphoma, 316
  Thomas M. Habermann
• 50 Mycosis fungoides and Sézary syndrome, 323
  Stephane Dalle, Marie Perier-Muzet, Brigitte Balme, and Luc Thomas
• 51 Hematopoietic cell transplantation in indolent non-Hodgkin’s lymphoma, 327
  Saurabh Chhabra and Ginna G. Laport
• 52 Hematopoietic cell transplantation in diffuse large B-cell lymphoma, 332
  Syed A. Abutalib and Istvan Redei
• 53 Hematopoietic cell transplantation in T-cell non-Hodgkin’s lymphomas, 339
  Lori S. Muffly and Sonali M. Smith

Part 8 | Plasma Cell Neoplasms and Related Disorders

• 54 Smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, 347
  Robert A. Kyle
• 55 Risk stratification and response assessment in multiple myeloma and Waldenström’s macroglobulinemia, 352
  Silvia Gentili and Sagar Lonial
• 56 Treatment of multiple myeloma, 358
  Cindy Varga, Claudia Paba Prada, Kenneth Anderson, and Paul Richardson
• 57 Light-chain amyloidosis, 366
  David C. Seldin
• 58 Waldenström’s macroglobulinemia, 371
  Anita D’Souza and Morie A. Gertz
• 59 Autologous hematopoietic cell transplantation in multiple myeloma, 376
  Jean-Luc Harousseau and Mohamad Mohty
• 60 Allogeneic hematopoietic cell transplantation in multiple myeloma, 381
  Jasleen Randhawa, Veerpal Singh, and Parameswaran Hari

Part 9 | Special Issues in Hematology

• 61 Role of PET scan in lymphomas, 391
  Matthew A. Lunning and James O. Armitage
• 62 Radioimmunotherapy in lymphomas, 398
  Reem Karmali and Stephanie A. Gregory
• 63 Radiation oncology consultation for hematologic malignancies, 403
  Chris R. Kelsey and Leonard R. Prosnitz

Part 10 | Special Issues in Hematopoietic Cell Transplantation

• 64 Donor and graft selection in allogeneic hematopoietic cell transplantation, 411
  Jose Leonel Ochoa-Bayona and Claudio Anasetti
• 65 Preparative regimens in allogeneic hematopoietic cell transplantation for malignant hematological
  diseases, 417
  Robert J. Soiffer
• 66 T-cell depletion in allogeneic hematopoietic cell transplantation, 421
  Jenna D. Goldberg and Miguel-Angel Perales
• 67 Prevention and treatment of relapse following hematopoietic cell transplantation, 426
  Robert Chen, Sandra Thomas, and Stephen J. Forman
• 68 Acute graft-versus-host disease, 432
  Andrew C. Harris and John E. Levine
• 69 Chronic graft-versus-host disease, 438
  Carrie L. Kitko and Daniel R. Couriel

Section 2 | Oncology

Part 1 | Central Nervous System Tumors

• 70 Primary brain tumors, 449
  Barbara J. O’Brien and Mark R. Gilbert
• 71 Secondary brain and spinal cord tumors, 457
  Rimas V. Lukas, Patrik Gabikian, and Steven J. Chmura

Part 2 | Head and Neck Cancers and Thoracic Malignancies

• 72 Medical management of head and neck cancers, 467
  Tobenna Nwizu and David Adelstein
• 73 Endocrine malignancies, 476
  Ann W. Gramza
• 74 Methodological and practical challenges for personalized therapies in non-small-cell lung cancer, 480
  Ignacio I. Wistuba
• 75 Screening, staging, and stage I non-small-cell lung cancer, 486
  Tarek M. Mekhail
• 76 Stage II and III non-small-cell lung cancer, 493
  Grzegorz Korpanty and Natasha B. Leighl
• 77 Recurrent and metastatic non-small-cell lung cancer and novel targets, 500
  Evan Pisick and Ravi Salgia
• 78 Small-cell lung cancer, 503
  Stephen V. Liu and Glen J. Weiss
• 79 Mesothelioma, 506
  Christopher W. Towe and Harvey I. Pass

Part 3 | Breast Cancer

• 80 Immunohistochemistry testing and beyond in breast cancer, 515
  Alejandro A. Gru and D. Craig Allred
• 81 Prevention and adjuvant therapy in breast cancer, 523
  Faithlore P. Gardner and Edith A. Perez
• 82 Preoperative systemic therapy for breast cancer, 532
  Virginia Kaklamani and William J. Gradishar
• 83 Recurrent and metastatic breast cancer, 540
  Dennis L. Citrin
• 84 Special issues in the young and pregnant patient with breast cancer, 546
  Hatem A. Azim Jr. and Fedro A. Peccatori

Part 4 | Gastrointestinal Oncology

• 85 Early-stage esophageal and stomach cancers, 555
  M. Naomi Horiba and Yixing Jiang
• 86 Metastatic esophagogastric cancer: controversies, consensus, and new targets, 562
  Geoffrey Y. Ku and David H. Ilson
• 87 Early-stage colorectal cancer, 567
  Vaibhav Sahai and Al B. Benson III
• 88 Recurrent and metastatic colorectal cancer: controversies, consensus, and new targets, 573
  Davendra Sohal and Robert J. Pelley
• 89 Pancreatic cancer, 581
  Katherine Van Loon and Margaret Tempero
• 90 Hepatobiliary cancer, 590
  Keith Stuart
• 91 Neuroendocrine tumors, 595
  Anya Litvak and Leonard Saltz
• 92 Transarterial liver-directed therapies in oncology, 601
  Divyesh G. Mehta and Jeffery Choh
• 93 Anal cancer, 606
  Rob Glynne Jones

Part 5 | Genitourinary Oncology

• 94 Renal cancer: tumor diversity, molecular taxonomy, and prognostic algorithms, 615
  Henry J. Conter and Eric Jonasch
• 95 Medical management of renal cancer, 621
  Gary R. MacVicar and Timothy M. Kuzel
• 96 Medical management of bladder cancer, 628
  Gary R. MacVicar and Timothy M. Kuzel
• 97 Prostate cancer: Screening, surveillance, prognostic algorithms and independent pathologic predictive
  parameters, 634
  Megan G. Lockyer and Thomas M. Wheeler
• 98 Medical management of prostate cancer, 638
  Elizabeth K. O’Donnell and Philip Kantoff
• 99 Germ cell tumors, 645
  Timothy Gilligan

Part 6 | Skin Malignancies

• 100 Medical management of melanoma, 653
  Ana M. Ciurea and Kim Margolin
• 101 Nonmelanoma skin cancers, 661
  Daniel Christiansen and Anna Sancho Clayton

Part 7 | Gynecological Malignancies

• 102 Ovarian cancer: neoadjuvant, adjuvant, and surgical issues, 669
  Alpa M. Nick and Robert L. Coleman
• 103 Ovarian cancer: second-line treatment strategies, 675
  Maurie Markman
• 104 Endometrial and cervical cancers, 681
  Maurie Markman

Part 8 | Sarcomas

• 105 Bone sarcomas, 689
  Nicole Larrier, William C. Eward, and Richard F. Riedel
• 106 Soft tissue sarcomas, 696
  Neeta Somaiah and Shreyaskumar Patel

Part 9 | Multidisciplinary Approach: Consultation with Surgical Oncology Team

• 107 Surgical aspects of head and neck cancers, 707
  Constance E.H. Teo and Randal S. Weber
• 108 Surgical aspects of thoracic malignancies, 711
  Albert S.Y. Chang, Thomas A. D’Amico, and David C. White
• 109 Surgical aspects of upper gastrointestinal cancers, 719
  Sabha Ganai and Mitchell C. Posner
• 110 Surgical aspects of pancreatic cancer, 723
  Amanda B. Cooper, Ching-Wei D. Tzeng, and Matthew H.G. Katz
• 111 Surgical aspects of hepatobiliary tumors, 729
  Subhasis Misra and Leonidas Koniaris
• 112 Surgical aspects of lower gastrointestinal cancers, 735
  Anthony J. Senagore
• 113 Surgical aspects of renal cancer, 739
  Michael E. Woods and Matthew C. Raynor
• 114 Surgical aspects of bladder cancer, 744
  Michael B. Williams
• 115 Surgical aspects of prostate cancer, 747
  Peter Pinto
• 116 Surgical aspects of melanoma, 754
  Thomas Velancia

Part 10 | Multidisciplinary Approach: Consultation with Radiation Oncology Team

• 117 Radiotherapy for head and neck cancers, 761
  Shiyu Song
• 118 Radiotherapy for ductal carcinoma in situ (DCIS), 767
  Beryl McCormick
• 119 Radiotherapy for early-stage invasive breast cancer, 771
  Julia White
• 120 Radiotherapy for thoracic malignancies, 778
  Meredith E. Giuliani and Andrea Bezjak
• 121 Radiotherapy for gastrointestinal malignancies, 785
  Manisha Palta, Christopher Willett, and Brian Czito
• 122 Radiotherapy for genitourinary malignancies, 789
  Christina H. Chapman and Curtiland Deville

Part 11 | Hereditary Cancer Syndromes and Genetic Testing in Oncology

• 123 When to suspect hereditary cancer syndromes, 795
  Emily Dalton and Kathy Schneider
• 124 Hereditary breast cancer syndromes, 800
  Kathy Schneider and Emily Dalton
• 125 Genetic testing in gastrointestinal tumors, 804
  Kristen M. Shannon and Daniel C. Chung
• 126 Hereditary urogenital cancer syndromes, 810
  Melanie Corbman and Eric Fowler

Part 12 | Special Issues in Hematology and Oncology

• 127 Carcinoma of unknown primary (CUP), 817
  Isabella C. Glitza and Gauri R. Varadhachary
• 128 Geriatric oncology, 822
  Nayana Kamath and Supriya Gupta Mohile
• 129 Nuts and bolts of cancer immunotherapy, 826
  Christopher R. Heery and James L. Gulley
• 130 Controversies related to oncology clinical trial development, 831
  Elihu H. Estey
• 131 PET scan in oncology, 835
  Shaunagh McDermott and Michael A. Blake
• 132 Hematopoietic growth factors, 841
  LeAnn B. Norris, Jametta Magwood, and Charles L. Bennett
• 133 Anticoagulation issues in oncology, 844
  Steven M. Corsello and Jean Marie Connors
• 134 Symptom management and palliative care, 851
  Rony Dev and Eduardo D. Bruera
• 135 Metabolic and nutritional issues in oncology, 860
  Julia Fechtner, Carolyn Lammersfeld, Carol Ireton-Jones, and Pankaj Vashi
• 136 Bone-related issues in oncology, 867
  S. Mujtaba Rizvi, Helen Collins, and Alan Lipton
• 137 Integrative medicine in oncology, 872
  Weidong Lu and David S. Rosenthal
• 138 Naturopathic medicine in oncology, 879
  Christina M. Shannon, Tracey Thomas, and Shauna Birdsall
• 139 Anesthesiology consultation for localized cancer pain, 884
  Abed Rahman, Magdalena Anitescu, and Raed Rahman
• 140 Musculoskeletal care in oncology, 893
  James E. Rosenberg and Charles A. McDonald
• 141 Cancer survivorship and psychosocial issues in oncology, 896
  Jabeen Abutalib, Shahid Raza, and Laura Sunn

Index, 902

Color plate section facing p.522