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Methods and Applications of Statistics in Clinical Trials, Vol. 1: Concepts, Principles, Trials, and Designs
Balakrishnan, N.
1ª Edición Marzo 2014
Inglés
Tapa dura
986 pags
1805 gr
15 x 25 x 5 cm
ISBN 9781118304730
Editorial WILEY
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Description
Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs focuses on all the key principles, various clinical trials used and different designs that could be applied for clinical trials. This volume discusses the key statistical concepts that are essential in understanding how to design and construction of clinical trials. This volume provides detailed explanations of statistical concepts such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, which are used in creating and analyzing the data gleaned from clinical trials. Volume 1 also presents several detailed overviews of various trial designs that can be found within the various phase I-IV trials, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials. In addition, an overview is presented of various clinical trials that are currently active, including AIDS clinical trials group (ACTG), early cancer & heart disease clinical trials, multiple risk factor intervention trial (MRFIT), and mother to child human immunodeficiency virus transmission trials.
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