Micrornas in Medicine

Description

MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics.

Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.

Table of Contents

Foreword
Prof. Sir David Baulcombe
(University of Cambridge, UK)

Chapter 1. MicroRNAs: A brief introduction
Prof. Charles H. Lawrie
(Biodonostia Research Institute, San Sebastián, Spain & University of Oxford, UK)

Section I: MicroRNAs as physiological regulators

Chapter 2. MicroRNA regulation of stem cell fate and reprogramming
Dr Erica Vivas, Dr Gustavo Tiscornia & Prof. Juan Carlos Izpisua Belmonte.
(Centre for Regenrative Medicine, Barcelona, Spain & Salk Institute for Biological Studies, California, USA)

Chapter 3. MicroRNAs as regulators of immunity
Dr. Donald Gracias & Prof. Peter D. Katsikis
(Drexel University College of Medicine, Philadelphia, USA)

Chapter 4. Regulation of senescence by microRNAs
Dr Ioannis Grammatikakis & Dr Myriam Gorospe
(National Institute of Aging, Baltimore, USA)

Chapter 5. The emergence of geroMIRS: A group of microRNAs implicated in aging
Dr Alejandro Ugalde, Dr Agnieszka Kwarciak, Dr Xurde Caravia, Prof. Carlos Lopez-Otín & Dr Andrew Ramsay
(University of Oviedo, Spain)

Chapter 6. MicroRNAs and hematopoiesis
Dr Sukhinder Sandhu & Prof. Ramiro Garzon
(Ohio State University, Ohio, USA)

Chapter 7. MicroRNAs in platelet production and activation
Dr Leonard Edelstein, Dr Srikanth Nagalla & Prof. Paul Bray
(Thomas Jefferson University, Philadelphia, USA)

Section II: MicroRNAs in infectious disease: host-pathogen interactions

Chapter 8. MicroRNAs as key players in host-virus interactions
Dr Aurélie Fender & Dr Sébastien Pfeffer
(University of Strasbourg, France)

Chapter 9. MicroRNA expression in avian herpesviruses
Dr. Yongxiu Yao & Prof. Venugopal Nair
(BBSRC Institute of Animal Health, Compton, UK)

Chapter 10. Function of human cytomegalovirus microRNAs and potential roles in latency
Dr Natalie Reynolds, Dr Jon Pavelin & Dr Finn Grey
(University of Edinburgh, Edinburgh, UK)

Chapter 11.Involvement of small non-coding RNA in HIV-1 infection-
Dr Guihua Sun, Prof. John Rossi & Dr Daniela Castanotto
(City of Hope National Medical Center, California, USA)

Chapter 12. MicroRNA in malaria
Dr Panote Prapansilp & Prof. Gareth Turner
(Mahidol University, Thailand & University of Oxford, UK)

Section III: Cancer

Chapter 13. The microRNA decalog of cancer involvement
Dr Tanja Kunej, Dr Irena Godnic, Dr Minja Zorc, Dr Simon Horvat & Prof. George Calin
(University of Ljubljana, Domzale, Slovenia; Rothamsted Research, Herts, UK; & MD Anderson Cancer Center, Texas, USA)

Chapter 14. MicroRNAs as oncogenes and tumor suppressors
Dr Eva Rufino-Palomares, Dr Fernando Reyes-Zurita, Dr Jose Lupiáñez & Dr Pedro Medina
(University of Granada, Spain)

Chapter 15. Long non-coding RNAs and their roles in cancer
Dr Yolanda Sánchez & Dr Maite Huarte
(University of Navarra, Spain)

Chapter 16. Regulation of hypoxia responses by microRNA expression
Dr Carme Camps, Prof. Adrian Harris & Dr Jiannis Ragoussis
(University of Oxford, UK)

Chapter 17. Control of receptor function by microRNAs in breast cancer
Dr Claudia Piovan & Dr Marilena Iorio
(Ohio State University, Ohio, USA & Istituto Nazionale Tumori, Milan, Italy)

Chapter 18. MicroRNAs in human prostate cancer: From pathogenesis to therapeutic implications
Dr. Mustafa Ozen & Dr Omer Karatas
(Istanbul University, Istanbul, Turkey & Baylor College of Medicine, Texas, USA)

Chapter 19. MicroRNA signatures as biomarkers of colorectal cancer –
Dr Katrin Pfütze, Dr Xiaoya Luo & Prof. Barbara Burwinkel
(University of Heidelberg, Germany)

Chapter 20. Genetic variations in microRNA-encoding sequences and microRNA target sites alter lung cancer susceptibility and survival
Dr Min Yang & Prof. Dongxin Lin
(Chinese Academy of Medical Sciences, Beijing, China)

Chapter 21. MicroRNAs in myelopoiesis and myeloid disorders
Dr Sara Meyer & Prof. Lee Grimes
(Cincinnati Children's Hospital Medical Center, Ohio, USA)

Chapter 22. MicroRNA deregulation by aberrant DNA methylation in acute lymphoblastic leukemia
Dr Xabier Agirre & Dr Felipe Prósper
(University of Navarra, Spain)

Chapter 23. Role of miRNAs in the pathogenesis of chronic lymphocytic leukemia
Dr Veronica Balatti, Prof. Yuri Pekarky, Dr Lara Rizzotto & Prof. Carlo Croce
(Ohio State University, Ohio, USA)

Chapter 24. MicroRNA in B-cell non-Hodgkin lymphoma: Diagnostic markers and therapeutic targets
Dr Nerea Martínez, Dr Lorena Di Lisio & Prof. Miguel Piris
(Hospital Universitario Marqués de Valdecilla, Santander, Spain)

Chapter 25. MicroRNAs in diffuse large B-cell lymphoma
Prof. Izidore Lossos & Dr Alvaro Alencar
(University of Miami, Florida, USA)

Chapter 26. The role of microRNAs in Hodgkin lymphoma
Dr. Wouter Plattel, Dr. Joost Kluiver, Dr Arjan Diepstra, Dr Lydia Visser & Prof. Anke van den Berg
(University of Groningen, The Netherlands)

Chapter 27. MicroRNA expression in cutaneous T-cell lymphomas ­
Prof. Cornelis Tensen
(University of Leiden, The Netherlands)

Section IV: Hereditary and other non-infectious diseases

Chapter 28. MicroRNAs and hereditary disorders
Dr Matías Morín and Prof. Miguel Moreno-Pelayo
(Ramón y Cajal Institute of Health Research, Madrid, Spain)

Chapter 29. MicroRNAs and cardiovascular diseases
Prof. Koh Ono
(Kyoto University, Japan)

Chapter 30. MicroRNAs and diabetes
Prof. Ramono Regazzi
(University of Lausanne, Switzerland)

Chapter 31. MicroRNAs in liver disease
Dr Patricia Munoz-Garrido, Dr Marco Marzioni, Dr Elizabeth Hijona, Dr Luis Bujanda & Dr Jesus Banales
(Biodonostia Research Institute, San Sebastián, Spain & Università Politecnica delle Marche, Ancona, Italy)

Chapter 32. MicroRNA regulation in multiple sclerosis
Dr Andreas Junker
(Georg-August University, Göttingen, Germany)

Chapter 33. The role of microRNAs in Alzheimer’s disease
Dr Shahar Barbash & Prof. Hermona Soreq
(Hebrew University of Jerusalem, Israel)

Chapter 34. Current views on the role microRNAs in psychosis
Dr Aoife Kearney, Dr Javier Bravo & Prof. Timothy Dinan
(University of Cork, Ireland)

Section V: Circulating microRNAs as cellular messengers and novel biomarkers

Chapter 35. Circulating microRNAs as non-invasive biomarkers
Ass. Prof. Heidi Schwarzenbach & Prof. Klaus Pantel
(University Medical Center Hamburg, Germany)

Chapter 36. Circulating microRNAs as cellular messengers
Prof. Kasey Vickers
(Vanderbilt University School of Medicine, Tennessee, USA)

Chapter 37.Release of microRNA-containing vesicles can stimulate angiogenesis and metastasis in renal carcinoma
Dr Federica Collino, Dr Cristina Grange & Prof. Giovanni Camussi
(Centre for Research in Experimental Medicine, Turin, Italy)

Section VI: Therapeutic uses of microRNAs: Current perspectives and future directions

Chapter 38. MicroRNA regulation of cancer stem cells and microRNAs as potential cancer stem cell therapeutics
Dr Can Liu & Prof. Dean Tang
(M.D. Anderson Cancer Center, Texas, USA)

Chapter 39. Therapeutic modulation of microRNAs
Prof. AchimAigner& Dr HanneloreDassow
(University of Leipzig, Germany)

Chapter 40. Silencing of MicroRNA-122 in primates with Chronic Hepatitis C Virus Infection
Dr Henrik Ørum
(Santaris Pharma, Denmark)