Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.
- Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
- Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
- Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types
Table of Contents
SECTION 1: INTRODUCTION
- Ch01 Different stem cell types and their potential for cancer therapeutics Angelo Vescovi and Khalid Shah
SECTION 2: MIGRATION AND FATE OF STEM CELLS
- Ch02 2.1. Role of CXCR4 in tumoritropic migration of stem cells. Moneeb Ehtesham
- Ch03 2.2. MMP-1 mediated tumoritrophic migration of stem cells. Paula Lam
SECTION 3: STEM CELL THERAPY IN BRAIN CANCER
- Ch04 3.1. Brain tumors and TRAIL mediated glioma therapy utilizing different
stem cell types.
- Ch05 3.2. Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy
- Ch06 3.3. Role of naïve cord blood stem cells on glioma therapy
Venkata Ramesh Dasari,Kiran Kumar Velpula, Christopher S. Gondi, Jasti S. Rao
- Ch07 3.4. Targeting brain tumor vasculature with engineered neural stem
Navid Redjal and Khalid Shah
- Ch08 3.5. Treatment of metastatic neuroblastoma with systemic oncolytic
virotherapy delivered by autologous mesenchymal stem cells.
Manuel Ramirez and Javier Garcia-Castro
SECTION 4: STEM CELL THERAPY IN OTHER CANCER TYPES
- Ch09 4.1. Umbilical cord matrix stem cells for cytotherapy of breast cancer
Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer, Masaaki Tamura
- Ch10 4.2. Mesenchymal stromal cells as effective tumor antigen-presenting
cells in cancer therapeutics
Raphaëlle Romieu-Mourez and Jacques Galipeau
- Ch11 4.3.Diagnostic and TherapeuticMesenchymal stem cell for breast cancer
- Ch12 4.4. Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal
Emily Keung, Peter J. Nelson and Claudius Conrad
- Ch13 4.5. Mesenchymal stem cells in prostate cancer: Clinical Opportunities.
Diptiman Chanda and Selvarangan Ponnazhagan
- Ch14 4.6. Primed mesenchymal stromal cells for cancer therapy
Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini and Giulio Alessandri
SECTION 5: COMBINATORIAL STEM CELL THERAPIES
- Ch15 5.1. Therapeutic efficacy of the combination of targeting microRNAs
and stem cell released therapeutics on tumors.
Maarten Anderegg and Marten Corsten
- Ch16 5.2. Therapeutic efficacy of PI3-Kinase inhibitors with stem cell delivered
TRAIL therapy in tumors.
- Ch17 5.3. The efficacy of clinically approved agents with stem cell delivered
therapeutics for cancer therapy.
Hiroaki Wakimoto and Khalid Shah
SECTION 6: TRACKING STEM CELLS AND STEM CELL BASED THERAPEUTICS
- Ch18 6.1. Imaging migration and fate of stem cells in different tumor models.
Deepak Bhere and Khalid Shah
- Ch19 6.2. Integrating therapeutic and diagnostic activities in stem cell expressing molecules to reveal multiple aspects of stem cell-based therapy. Shawn Hingtgen
- Ch20 6.3. Tracking cancer targeted MSC by PET imaging.
Véronique Roelants and Jean-Louis Vanoverschelde