The Molecular Biology of Cancer. a Bridge from Bench to Bedside (Hardcover)

Description

This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. The text offers in-depth coverage of traditional areas of study, while also discussing areas of controversy and emerging importance and highlighting future directions for research.

Table of contents

Introduction

Chapter 1: Overview of cancer biology
Mike Khan and Stella Pelengaris

Chapter 2: The burden of cancer
William P. Steward and Anne L. Thomas

Chapter 3: Nature and nurture in oncogenesis
Mike Khan and Stella Pelengaris

Chapter 4: DNA replication and the cell cycle
Mike Khan and Stella Pelengaris

Chapter 5: Growth Signalling Pathways and the New Era of Targeted Treatment of Cancer
Mike Khan and Stella Pelengaris

Chapter 6: Oncogenes
Stella Pelengaris and Mike Khan

Chapter 7: Tumour suppressor
Martine F. Roussel

Chapter 8: Cell death
Stella Pelengaris and Mike Khan

Chapter 9: Senescence, telomeres and cancer stem cells
Maria Blasco and Mike Khan

Chapter 10: Genetic instability, chromosomes and repair
Mike Khan

Chapter 11: There is more to cancer than genetics- regulation of gene and protein expression by epigenetic factors, small regulatory RNA’s and protein stability
Stella Pelengaris and Mike Khan

Chapter 12. Cell adhesion in cancer
Charles H. Streuli

Chapter 13: Tumor Immunity and Immunotherapy
Cassian Yee

Chapter 14: Tumor angiogenesis
Christiana Ruhrberg

Chapter 15: Cancer Chemistry: Designing New Drugs for Cancer Treatment
Ana M. Pizarro and Peter J. Sadler

Chapter 16: Biologically targeted agents from bench to bedside
Mike Khan and Stella Pelengaris

Chapter 17: The Diagnosis of cancer
Anne L. Thomas, Bruno Morgan and William P. Steward

Chapter 18: Treatment of cancer - chemotherapy and radiotherapy
Anne L. Thomas, J. P. Sage and William P. Steward

Chapter 19: Caring for the cancer patient
Nicky Rudd and Esther Waterhouse

Chapter 20: Systems Biology of Cancer
Walter Schubert, Norbert C. J. de Wit and Peter Walden

Index