The Design and Statistical Analysis of Animal Experiments

Written for animal researchers, this book provides a comprehensive guide to the design and statistical analysis of animal experiments. It has long been recognized that the proper implementation of these techniques helps reduce the number of animals needed. By using real-life examples to make them more accessible, this book explains the statistical tools employed by practitioners. A wide range of design types are considered, including block, factorial, nested, cross-over, dose-escalation and repeated measures and techniques are introduced to analyse the experimental data generated. Each analysis technique is described in non-mathematical terms, helping readers without a statistical background to understand key techniques such as t-tests, ANOVA, repeated measures, analysis of covariance, multiple comparison tests, non-parametric and survival analysis. This is also the first text to describe technical aspects of InVivoStat, a powerful open-source software package developed by the authors to enable animal researchers to analyze their data and obtain informative results.

• The first book to provide life scientists with a practical guide to using design and statistics when running experiments, improving decision-making while reducing animal use
• Explains design types and analysis techniques routinely employed by practitioners, using non-mathematical terms and drawing on real-life examples
• The first book to describe technical aspects of InVivoStat, a powerful open-source software package developed by the authors primarily for life scientists