Down syndrome is one of the most commonly occurring developmental disorders and it is now possible to conceptualize and define opportunities for neurocognitive rehabilitation for those with the condition. This book describes how early cognitive intervention in children with Down syndrome can be carried out, and can reduce, or compensate for, the major deficits characteristic of the condition. This comprehensive account relates the neurocognitive approach to the major therapeutic endeavors in the neighboring fields of neurogenetics, experimental environmental enrichment, molecular genetics, pharmacology, pediatrics and cardiology for infants with Down syndrome. Neurocognitive Rehabilitation of Down Syndrome provides the guidance required to establish effective rehabilitation programs, and is essential reading for developmental clinicians, pediatricians, neuropsychologists and other health professionals.
• Provides practical guidance on how to implement a systematic neurocognitive rehabilitation program • Covers every step from basic research to clinical application and assessment to promote maximum efficacy • Written by leading researchers from around the globe and presents the most up-to-date research
Preface; Part I. Definition, History, Methodology, and Assessment: 1. Early intervention: definition, objectives, models and challenges Juan Perera; 2. The history of rehabilitative intervention for infants and young children with Down syndrome and their families: where have we been and where are we going? Donna Spiker; 3. Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome Jamie Edgin, Goffredina Spano and Lynne Nadel; Part II. Genetics, Brain and Animal Models: 4. New perspectives on molecular and genetic therapies in Down syndrome Jean-Maurice Delabar; 5. Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome Adam Golabek, Katarzyna Jarzabek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini and Elizabeth Kida; 6. Development of the brain and metabolism David Patterson; Part III. Pharmacological and Medical Management and Treatment: 7. Pharmacotherapy for children with Down syndrome George Capone; 8. Early medical caretaking and follow-up Alberto Rasore-Quartino; 9. Evaluation and management of cardiovascular diseases in Down syndrome Guy Dembour and Stephane Moniotte; Part IV. Early Development and Intervention: 10. Developmental models as frameworks for early intervention with children with Down syndrome Katie Cohene, Heidi Flores and Jacob Burack; 11. Aspects of motor development in Down syndrome Naznin Virji-Babul, Anne Jobling, Digby Elliot and Daniel Weeks; 12. Memory development and learning Stefano Vicari and Deny Menghini; 13. Prelinguistic and early development, stimulation and training in children with Down syndrome Jean-Adolphe Rondal; 14. Speech perception, stimulation and phonological development Michele Pettinato; 15. Goal-directedness as a target for early intervention in Down syndrome Deborah Fidler, Susan L. Hepburn and Diane Osaki; 16. The role of parents of children with Down syndrome and other disabilities in early intervention Gerald Mahoney and Frida Perales; Part V. Therapeutic Perspectives: 17. Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome Jean-Adolphe Rondal and Juan Perera; Conclusions; Index.
Juan Perera, Donna Spiker, Jamie Edgin, Goffredina Spano, Lynne Nadel, Jean-Maurice Delabar, Adam Golabek, Katarzyna Jarzabek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini, Elizabeth Kida, David Patterson, George Capone, Alberto Rasore-Quartino, Guy Dembour, Stephane Moniotte, Katie Cohene, Heidi Flores, Jacob Burack, Naznin Virji-Babul, Anne Jobling, Digby Elliot, Daniel Weeks, Stefano Vicari, Deny Menghini, Jean-Adolphe Rondal, Michele Pettinato, Deborah Fidler, Susan L. Hepburn, Diane Osaki, Gerald Mahoney, Frida Perales