The Genetic Basis of Sleep and Sleep Disorders

Description

The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists.

• Summarizes research into the genetic basis of sleep disorders and applies results to the clinical setting ? accessible to clinicians
• Focuses on the most important sleep disorders ? useful in everyday practice, including counselling patients
• Internationally renowned contributors give the content authority and make it applicable to a worldwide market

Table of Contents

Preface
Part I. General Principles of Genetics and Genomics:
1. Methods in complex trait analysis: mapping the genetic basis of sleep using model organisms Amelie Baud and Jonathan Flint
2. Linkage and associations Elizabeth J. Rossin and Benjamin M. Neale
3. Genome-wide association study approaches to sleep phenotypes Patrick Sleiman, Michael March and Hakon Hakonanson
Part II. Genetics of Sleep and Circadian Rhythms:
4. Genetic epidemiology of sleep and sleep disorders Christer Hublin and Jaakko Kaprio
5. Drosophlia model systems for genetic sleep research Stephane Dissel and Paul J. Shaw
6. Caenorhabditis elegans and zebrafish in sleep research David A. Prober and David M. Raizen
7. Optogenetic control of arousal neurons Antoine Adamantidis, Matthew E. Carter and Luis De Lecea
8. Prostaglandin D2 in the regulation of sleep Yoshihiro Urade and Michael Lazarus
9. Astroglial regulation of sleep Marcos G. Frank
10. The role of metabolic genes in sleep regulation Matthew S. Thimgan and Karen D. Schilli
11. A systems biology approach for uncovering the genetic landscape for multiple sleep-wake traits Peng Jiang, Andrew Kasarskis, Christopher J. Winrow, John J. Renger and Fred W. Turek
12. Genetic control of the circadian pacemaker Ethan Buhr and Joseph S. Takahashi
13. Epigenetic basis of circadian rhythms and sleep disorders Irfan A. Qureshi and Mark F. Mehler
Part III. Sleep Physiology and Homeostasis:
14. Genetics of sleep and EEG Thomas Curie and Mehdi Tafti
15. Genetic interaction between circadian and homeostatic regulation of sleep Valérie Mongrain and Paul Franken
16. Genetic approaches to understanding circadian entrainment Till Roenneberg and Karla V. Allebrandt
17. Animal models for cognitive deficits induced by sleep deprivation Laurent Seugnet and Paul Salin
18. Individual differences in sleep duration and responses to sleep loss Devon A. Grant and Hans P. A. Van Dongen
19. Clock polymorphisms associated with human diurnal preference Simon N. Archer and Derk-Jan Dijk
20. Sleep and long-term memory storage Jennifer H. K. Choi and Ted Abel
21. Sleep and synaptic homeostasis Chiara Cirelli and Giulio Tononi
Part IV. Insomnias:
22. Heritability and genetic factors in chronic insomnia Yves Dauvilliers and Charles M. Morin
Part V. Narcolepsy and Hypersomnias:
23. HLA and narcolepsy Katsushi Tokunaga and Makoto Honda
24. Orexin (hypocretin) and narcolepsy Takeshi Sakurai and Seiji Nishino
25. Gene-wide association studies in narcolepsy Hyun Hor
26. Genetic disorders producing symptomaric narcolepsy Seiji Nishino and Takashi Kanbayashi
27. Genetics of recurrent hypersomnia Michael Billiard, Rosa Periata-Adrados and Mehdi Tafti
Part VI. Sleep-related Breathing Disorders:
28. Linkage and candidate gene studies of obstructive sleep apnea Annette C. Fedson, Thorarinn Gislason and Allan I. Pack
29. Genomic mutations and genotype-phenotype in pediatric sleep-related breathing disorders Leila Kheirandish-Gozal and David Gozal
Part VII. Circadian Rhythm Sleep Disorders:
30. Genetic of familial advanced sleep phase Suet Ying Chong, Louis J. Ptacek and Ying-Hui Fu
31. Delayed sleep phase disorder, circadian genes, sleep homeostasis and light sensitivity Simon N. Archer and Derk-Jan Dijk
Part VIII. Parasomnias and Sleep-related Movement Disorders:
32. Family and genome-wide association studies of restless legs syndrome Eva C. Schulte and Juliane Winkelmann
Part IX. Psychiatric and Medical Disorders:
33. Circadian clock genes and psychiatric disorders Marc Cuesta, Nicholas Cermakian and Diane B. Boivin
34. Genetics of autosomnal dominant nocturnal frontal lobe epilepsy Keivan Kaveh Moghadam and Giuseppe Plazzi
Part X. Medication Effects:
35. Gene therapy for sleep disorders Dheeraj Pelluru, RodaRani Konadhode, Carlos Blanco-Centurion, Meng Liu and Priyattam J. Shiromani
Index.

Authors

Paul Shaw, University of Washington, St Louis
Paul Shaw is Associate Professor of Anatomy and Neurobiology at Washington University, St Louis, MO, USA.

Mehdi Tafti, University of Lausanne
Mehdi Tafti is a Professor at the Center for Integrative Genomics at the Université de Lausanne, Lausanne, Switzerland.

Michael Thorpy, Sleep-Wake Disorders Center, Albert Einstein College of Medicine, Bronx, New York
Michael Thorpy is Professor of Clinical Neurology at Albert Einstein College of Medicine, New York and Director of the Sleep-Wake Disorders Center in the Department of Neurology at Montefiore Medical Center, New York, NY, USA.