White Matter Dementia

Description

Breaking away from prevailing views of dementia that rely heavily on the role of the cerebral cortex, the new perspective put forth here highlights white matter-cognition relationships, presenting an expanded view of dementia and its neurobiological origins. Based on detailed patient observations, extensive clinical research and an exhaustive literature review, this book discusses the novel concept of white matter dementia, offering hope for better understanding and treatment of dementing illness. Covering topics such as white matter neurobiology, mild cognitive dysfunction and Alzheimer's disease, the author reconsiders brain-behavior relationships and expands the concept of dementia, discussing implications for diagnosis, treatment (medical, surgical, rehabilitative, and psychiatric) and therapeutic innovations aimed at prevention of white matter damage and restoration of myelin. This unique book is an absolute must-have for all medical specialists and consultants in neurology, neuropsychiatry, and neuropsychology involved with the growing challenge of dementia.

• Offers a thorough and consistent account, emphasizing the role of white matter in cognition
• Will allow readers the opportunity to consider dementia in a new light
• Highlights key points in several contexts that can enhance clinical care and research
• Includes a chapter on therapeutic innovations

Contents

Preface
1. Brain-behavior relationships: a reconsideration
2. The essential contributions of neuroimaging
3. White matter neurobiology
4. A neuroanatomic overview of dementia
5. Expanding the concept of dementia
6. White matter disorders
7. White matter dementia
8. Mild cognitive dysfunction: a precursor syndrome
9. Diagnosis
10. Prognosis
11. Treatment
12. White matter and cognition: research perspectives
13. Therapeutic innovations
14. Alzheimer's disease and white matter
15. Chronic traumatic encephalopathy and white matter
16. Beyond corticocentrism
Index.

Author

Christopher M. Filley, University of Colorado School of Medicine
Christopher M. Filley is Professor of Neurology and Psychiatry and Director of the Behavioral Neurology Section at the University of Colorado School of Medicine, Aurora, CO, and Neurology Service Chief at the Denver Veterans Affairs Medical Center, Denver, CO, USA.