Lung Biology and Pathophysiology

Editor Biography
List of Contributors
Preface
Yutong Zhao
Acknowledgement

Part I: Lung Health and Pulmonary Diseases

Chapter 1 Antimicrobial Peptides in Lung Health and Pulmonary Diseases

Jenna M. Kuhn and Yuanpu Peter Di

Chapter 2 Alveolar Epithelium in Lung Injury and Repair

SeungHye Han

Chapter 3 Environmental Toxicants in Lung Diseases

Samuel J. Cochran, Evangeline Schott, Brett Saunders, and Kymberly M. Gowdy

Chapter 4 Epigenetic Modifications of Histone in Lung Fibrosis

Yan Y. Sanders

Chapter 5 Translational Potential of Hypoxia-inducible factor-2α Signaling in Pulmonary Hypertension

Zhiyu Dai

Part II: Research Strategies and Methods in Lung Biology and Pathophysiology

Chapter 6 Utility of Lung Organoids to Accelerate Our Understanding of Human Pulmonary Development and Diseases

Nicole Pek and Mingxia Gu

Chapter 7 Establishment of Animal Models of Pulmonary Fibrosis

Maolin Yao, Mo Chen, and Lian Li

Chapter 8 Research Strategies for Investigating Protein Ubiquitination in Lung Diseases

Yutong Zhao

Chapter 9 Peroxidative Metabolism of Lung Lipids in Pulmonary Health and Disease: Emphasis on Methods of Analysis of Oxidative Modification of Polyunsaturated Membrane Phospholipids

Austin C. Elliott, Lasya Kopuri, Surya Narla, Patrick J. Oliver, Anita Yenigalla, Elliott D. Crouser, Krishna Rao Maddipati, Thomas J. Hund, Narasimham L. Parinandi

Part III: Pathogenesis and Therapies of COVID-19

Chapter 10 Renin-Angiotensin System (RAS) and COVID-19: Exploring the Impact, Inhibition, and Treatment Strategies

Qing Lin and Hongpeng Jia

Chapter 11 COVID-19 Therapeutics: Challenges and Opportunities

Travis B. Lear, Bill B. Chen, and Yuan Liu

Chapter 12 Clinical manifestations and pathogenesis of COVID-19 pulmonary disease

Moemen Eltobgy, Finny Johns, and Joseph S. Bednash

Part IV: Traditional Chinese Medicine in Lung Diseases

Chapter 13 Pulmonary Diseases and Traditional Chinese Medicine

Baochang Zhao, Xiaohong Shu, and Hong Zhang

The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease, and cystic fibrosis, etc., resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics. Key Features

• Highlights the role the lungs play as an interface between the body and the environment.
• Describes the underlying mechanism of lung diseases.
• Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function.
• Includes contributions from leading researchers.

Yutong Zhao is a Professor of Physiology and Cell Biology at the Ohio State University. He received his clinical medical degree from Dalian Medical University in China and PhD degree from Gifu University School of Medicine in Japan. He was trained in biochemistry, molecular biology, and active lipid signaling during his PhD student period. He joined a pulmonary postdoctoral training program in Johns Hopkins University School of Medicine and received his first NIH R01 funding at the University of Chicago as a Research Assistant Professor. Dr. Zhao is an expert in research fields of lung biology, bioactive lysophospholipid, and protein ubiquitination. His research focuses on investigating the pathogenesis of lung diseases including acute respiratory distress syndrome, pulmonary fibrosis, pulmonary arterial hypertension, asthma, lung cancer, and COPD. The goal of Dr. Zhao’s laboratory research is to develop new therapeutic targets for treating lung diseases. Dr. Zhao is active in in academic professional services as a reviewer, associate editor, member of editorial board of scientific journals and grant review study sections.